Curcumin protects against gallic acid-induced oxidative stress, suppression of glutathione antioxidant defenses, hepatic and renal damage in rats

Abarikwu, Sunny O.; Durojaiye, Mojisola A.; Adenike, Alabi; Asonye, Bede; Akiri, Oghenetega F.

doi:10.3109/0886022x.2015.1127743

Cited by 25 publications

(9 citation statements)

References 42 publications

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“…e possibility of an intracellular nonenzymatic metabolic activation of curcuminoids dependent on GSH, NADH, or NADPH has also been suggested that could act as a "cellular switch," which could regulate cellular antioxidant defenses. e results of this study are in agreement with the observations of other related studies [27,28], which reported curcuminoids induction of the expression and/or activity of GST, GSH-Px, SOD, and glutathione reductase. Consequently, CL improved plasma and liver antioxidant ability and increased expression of liver antioxidant genes.…”

Section: Discussionsupporting

confidence: 93%

Ultrastructural Changes in Hepatocytes and Chemopreventive Effects of Short‐Term Administration of Curcuma longa L. against Oxidative Stress‐Induced Toxicity: Improvement Mechanisms of Liver Detoxification

Hasan

2020

Evidence-Based Complementary and Alternative Medicine

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The rhizomes of Curcuma longa L. (CL) have been widely used in herbal medicines worldwide. It has been shown to possess prophylactic effects against oxidative stress. However, there is a paucity of information regarding the protective role of CL against oxidative stress in the absence of toxic agents. The aim of the study was to elucidate the antioxidative stress pharmacodynamics of CL. Eighteen 12-week-old Sprague-Dawley rats weighing about 300 ± 25 gm were divided equally into six groups. Four of the groups were supplemented with CL at 100 mg/kg b.w./day orally (P.O.) and labeled as 1st, 3rd, 5th, and 6th day groups. The PCx (positive control) group was given distilled water orally, and the NCx (negative control) group rats were provided with food and water ad libitum. Blood samples were collected, and rats were sacrificed on days 1, 3, 5, and 6 (2 h) posttreatment. The blood was used for oxidative stress enzyme analysis (SOD, GSH-Px, and MDA) and liver (ALT) and kidney (creatinine) function assay, and the liver was dissected for histology. The results revealed that CL exhibited an antioxidative stress effect in the liver and kidneys as indicated by the low levels of ALT and creatinine. In response to antioxidant enzymes, especially that of the 3rd-day treatment group, an increase in SOD and GSH-Px indirectly caused an alleviation of oxidative stress, leading to a much lower level of MDA. It was concluded that treatment with CL at 100 mg/kg b.w./per day for three consecutive days demonstrated the highest efficacy in abating oxidative stress in rats.

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Section: Discussionsupporting

confidence: 93%

Ultrastructural Changes in Hepatocytes and Chemopreventive Effects of Short‐Term Administration of Curcuma longa L. against Oxidative Stress‐Induced Toxicity: Improvement Mechanisms of Liver Detoxification

Hasan

2020

Evidence-Based Complementary and Alternative Medicine

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“…Members of thiol redox system such as reduced glutathione (GSH) and glutathione peroxidase (GPx) have a main role in scavenging the ROS in several cells 24 . Curcumin supports the GSH concentration and GPx activity in kidney cells 38,39 . Thiol groups also have a main role in the activation of TRPM2 channels.…”

Section: Resultsmentioning

confidence: 95%

Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

Nazıroğlu

Çiğ

Yazğan

et al. 2019

Sci Rep

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In proteinuric nephropathies of chronic kidney disease, the epithelial cells of the nephron including the collecting duct are exposed to high concentrations of luminal albumin. Albumin is taken up from collecting duct cells by endocytosis causing excessive reactive oxygen species (ROS) production and a proinflammatory response. Curcumin used in the traditional medicine possesses anti-inflammatory and antioxidant effects. ROS and ADP-ribose (ADPR) activate the cation channel TRPM2. We hypothesize, that albumin-induced cell stress and proinflammatory response are mediated by Ca 2+ and can be reduced by curcumin. The cortical collecting duct (CCD) cells mpkCCD c14 exhibit spontaneous and inducible Ca 2+ oscillations, which can be blocked by pre-treatment with curcumin. Curcumin accumulates in plasma membrane and intracellular vesicles, where it interferes with TRPM2 and decreases the influx of Ca 2+ . Albumin reduces cell viability and increases apoptosis, NF-κB activation, and mitochondrial membrane depolarization via Ca 2+ -dependent signaling, which results in increased ROS production. Albumin-induced cell stress is diminished by the inhibition of TRPM2 after administration of curcumin and ADPR (PARP1) inhibitors. Curcumin did not reduce the Ca2+ elevation induced by thapsigargin in Ca 2+ -free medium, but it reduced the function of store-operated Ca 2+ channels and ATP-evoked Ca 2+ response. In conclusion, albumin-induced oxidative stress is mediated by Ca 2+ -dependent signaling via TRPM2 and leads to cell damage and a proinflammatory response, strengthening the role of CCD cells in the progression of chronic kidney disease.

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“…This is reported to be due to their low intestinal absorption in the biological system [ 5 ] or that different interstitial concentrations are required for different tissues [ 3 ]. For instance, gallic acid (GAL) has the capacity to act as pro-oxidant at high doses and produces deleterious effects in tissues [ [6] , [7] , [8] ] whereas, at low doses it acts as antioxidant and exerts beneficial effects on the health of humans including cardiovascular diseases, chemoprevention of cancers and mitochondrial damage of several tissues [ [9] , [10] , [11] ]. Furthermore, several studies with many phytochemicals including quercetin (QUE), hesperetin, naringenin, myricetin and morin have established that these flavonoids have both antioxidant and pro-oxidant effects at different doses [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Tissues that are endowed with antioxidant protective agents are less vulnerable to oxidative damage and are said to be in good health status [ 4 ]. In our previous studies, GAL at 100 mg/kg body weight produces deleterious effects on the testis, kidney and liver [ 4 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

et al. 2020

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Curcumin protects against gallic acid-induced oxidative stress, suppression of glutathione antioxidant defenses, hepatic and renal damage in rats

Cited by 25 publications

References 42 publications

Ultrastructural Changes in Hepatocytes and Chemopreventive Effects of Short‐Term Administration of Curcuma longa L. against Oxidative Stress‐Induced Toxicity: Improvement Mechanisms of Liver Detoxification

Ultrastructural Changes in Hepatocytes and Chemopreventive Effects of Short‐Term Administration of Curcuma longa L. against Oxidative Stress‐Induced Toxicity: Improvement Mechanisms of Liver Detoxification

Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

Evaluation of the protective effects of quercetin and gallic acid against oxidative toxicity in rat’s kidney and HEK-293 cells

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