Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity

Sortase A: An ideal target for anti-virulence drug development

“…The activity of Curcuma longa L. (turmeric) rhizome constituents against SrtA have also been extensively studied [54][55][56]. The curcuminoid curcumin was shown to inhibit S. aureus SrtA with an IC 50 value of 13.8 ± 0.7 mg/ml, showing no growth inhibition even at MIC values greater than 200 mg/ml, but resulting in potent inhibition of S. aureus cell adhesion to fibronectin.…”

Curcumin-Hydroxypropyl-β-Cyclodextrin Inclusion Complex Preparation Methods: Effect of Common Solvent Evaporation, Freeze Drying, and pH Shift on Solubility and Stability of Curcumin

“…Although, it has shown many excellent pharmacological activities in in vitro experiments such as antioxidant, antiinflammatory, anti-microbial and also anti-tumor activities [1][2][3][4], curcumin has not yet been approved for use as a drug due to the very low bioavailability obtained after curcumin oral administration, which is due, in part, to poor solubility (11 ng/mL in aqueous buffer, pH 5.5 [5]) and stability (t 1/2 of curcumin in PBS pH 7.2, < 10 min [6]). Many attempts have been made to solve these problems.…”

Antibacterial activity of curcumin (turmeric) against periopathogens - An in vitro evaluation

“…[21] In oral flora, curcumin inhibited sortase A of Streptococcus mutans, which is a major cariogenic bacteria, capable of reducing S. mutans biofilm formation. [22] Curcumin has shown antibacterial property against a number of Gram-positive and Gram-negative bacteria (Negi, 1999).…”