Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+/calmodulin-dependent kinase II activation

Takikawa, Masahito; Kurimoto, Yuta; Tsuda, Takanori

doi:10.1016/j.bbrc.2013.04.092

Cited by 57 publications

(49 citation statements)

References 34 publications

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“…As for GLP-1 release, it is regulated by various signaling pathways. Increased cytosolic Ca 2þ level is one reported possible molecular mechanism [19,20]. Given that elevation of cytosolic Ca 2þ may be caused by endogenous Ca 2þ store mobilization and/or extracellular influx through L-type Ca 2þ channel, we pre-incubated the FRIC with thapsigargin, an ER Ca 2þ ATPase inhibitor or nifedipine, an L-type Ca 2þ channel blocker.…”

Section: Discussionmentioning

confidence: 99%

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models

Guo

Ning

et al. 2015

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 99%

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models

Guo

Ning

et al. 2015

Biochemical and Biophysical Research Communications

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“…In previous investigations of dietary factors that function as GLP‐1 secretagogues, our group found curcumin to be a factor that functions at the cellular level . Curcumin's anti‐diabetes effects have been recently reported in a human study .…”

Section: Dietary Factors and Stimulation Of Glp‐1 Secretionmentioning

confidence: 90%

“…Values are means ± SEM, n = 3. Values without a common letter are significantly different at p < 0.05 . Reproduced with permission of Elsevier.…”

Section: Dietary Factors and Stimulation Of Glp‐1 Secretionmentioning

confidence: 99%

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Tsuda

2015

Molecular Nutrition Food Res

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There is a pressing need for countermeasures against diabetes, which has increased in incidence, becoming a global issue. Glucagon-like peptide-1 (GLP-1), a molecule secreted in enteroendocrine L cells in the lower small and large intestines, is thought to be one of the most important molecular targets for the prevention and treatment of diabetes. There has been increasing interest in the possible ability of dietary factors to treat diabetes via modulating GLP-1 secretion. There is thought to be a close relationship between incretin and diet, and the purported best approach for using dietary factors to increase GLP-1 activity is promotion of secretion of endogenous GLP-1. It have been reported that nutrients as well as various non-nutrient dietary factors can function as GLP-1 secretogogues. Here, we present our findings on the GLP-1 secretion-stimulating functions of two dietary factors, curcumin and extract of edible sweet potato leaves, which contain caffeoylquinic acid derivatives. However, it is necessary to reveal in greater detail the stimulation of GLP-1 secretion by dietary factors for preventing and treating diabetes. It is desirable to clarify the exact GLP-1 secretory pathway, the effect of metabolites derived from dietary factors in gut lumen, and the relationship between incretin and meal.

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“…Enhancing the GLP-1 action is an important target for prevention and treatment of type 2 diabetes. Takikawa et al 123 reported CUR significantly stimulated GLP-1 secretion in GLUTag cells and significant increase involved the Ca 2+ -CaMKII pathway and was independent of the cAMP/PKA, PKC and MEK-ERK pathways.…”

Section: Biological Activities Of Various Curcuminoid Formulationsmentioning

confidence: 98%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

730

413

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+/calmodulin-dependent kinase II activation

Cited by 57 publications

References 34 publications

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models

Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon‐like peptide‐1 secretion

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

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