Curcumin–Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects

Sareen, Rashmi; Jain, Nitin; Dhar, K.L.

doi:10.3109/10837450.2015.1041042

Cited by 41 publications

(26 citation statements)

References 16 publications

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“…The dose of curcumin used in this study was just 140 mg which was lower than the dose used in this study, indicating that curcumin indeed would be effective but with proper dosage and route of administration. There have been multiple studies on this aspect that have investigated various formulations of curcumin, some of which increase systemic bioavailability of curcumin and some have lead to increased colonic delivery[31,32]. In a mice study, Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a molar ratio of 1:1.…”

Section: Discussionmentioning

confidence: 99%

“…In a mice study, Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a molar ratio of 1:1. Kinetic stability studies showed a good stability of the metallo-complex with zinc and in vivo study revealed a significant reduction in severity and extent of colonic damage with this preparation[31]. Another study assessed the role of pH-triggered Eudragit-coated chitosan microspheres of curcumin in managing UC.…”

Section: Discussionmentioning

confidence: 99%

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Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial

Kedia

Bhatia

Thareja

et al. 2017

WJGPT

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AIMTo evaluate the role of oral curcumin in inducing clinical remission in patients with mild to moderate ulcerative colitis (UC).METHODSA prospective randomized double-blind placebo-controlled trial comparing the remission inducing effect of oral curcumin and mesalamine 2.4 g with placebo and mesalamine 2.4 g in patients of ulcerative colitis with mild to moderate severity was conducted from January 2003 to March 2005. The included patients received 1 capsule thrice a day of placebo or curcumin (150 mg) for 8 wk. Patients were evaluated clinically and endoscopically at 0, 4 and 8 wk. The primary outcome was clinical remission at 8 wk and secondary outcomes were clinical response, mucosal healing and treatment failure at 8 wk. The primary analysis was intention to treat worst case scenario (ITT-WCS).RESULTSOf 300 patients with UC, 62 patients (curcumin: 29, placebo: 33) fulfilled the inclusion criteria and were randomized at baseline. Of these, 21 patients did not complete the trial, 41 patients (curcumin: 16, placebo: 25) finally completed 8 wk. There was no significant difference in rates of clinical remission (31.3% vs 27.3%, P = 0.75), clinical response (20.7% vs 36.4%, P = 0.18), mucosal healing (34.5% vs 30.3%, P = 0.72), and treatment failure (25% vs 18.5%, P = 0.59) between curcumin and placebo at 8 wk.CONCLUSIONLow dose oral curcumin at a dose of 450 mg/d was ineffective in inducing remission in mild to moderate cases of UC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial

Kedia

Bhatia

Thareja

et al. 2017

WJGPT

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“…Priyadarsini (2014) [ 75 ] has comprehensively reviewed different extraction methods and curcumin conjugates, along with advances in improvements in curcumin delivery systems involving nanoparticles, due to hydrophobic nature of curcumin. Effective and simple chelation of zinc with curcumin to improve its bioavailability has been demonstrated [ 139 ]. Feed addition of curcumin to enhance immune status is well reported as reviewed earlier.…”

Section: Curcumin Extraction and Feed Applicationmentioning

confidence: 99%

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Limaye

Chou

et al. 2018

Toxins

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Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, suppressing pro-apoptotic proteins and improving immune status in AFB1 affected animals; selenium confers specific protection against AFB1 toxicity. Meticulous supplementation of animal feed by elemental selenium in the organic and inorganic forms has proven to be effective to ameliorate AFB1 toxicity. Curcumin is another dietary agent of importance in tackling aflatoxicosis. Curcumin is one of the major active ingredients in the tubers of a spice Curcuma longa L., a widely reported antioxidant, anticarcinogenic agent with reported protective potential against aflatoxin-mediated liver damage. Curcumin restricts the aflatoxigenic potential of Aspergillus flavus. Curcumin inhibits cytochrome P450 isoenzymes, particularly CYP2A6 isoform; thereby reducing the formation of AFB1-8, 9-epoxide and other toxic metabolites causing aflatoxicosis. In this review, we have briefly reviewed important aflatoxicosis symptoms among animals. With the main focus on curcumin and selenium, we have reviewed their underlying protective mechanisms in different animals along with their extraction and production methods for feed applications.Keywords: aflatoxin B1; anti-AFB1 dietary supplement; curcumin; selenium; antioxidant status Key contribution: We have reviewed protective roles of selenium and curcumin in specific relation to tacking AFB1 toxicity in the livestock along with their reported underlying mechanisms for the potential feed applications catering across a broad host range.

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“…Alongside the use of nanoparticles, liposomes, micelles, and phospholipid complexes to better improve the bioavailability of curcumin, curcumin complexation with transition metal ions represents yet another approach to circumvent the challenges mentioned above. In one study, it was found that a curcumin–Zn 2+ complex improved the solubility, stability, and the pharmacodynamic effects of curcumin . Because of the highly conjugated ß‐diketone moiety in the chemical structure of curcumin, it can readily form metal chelates of type 1:1 and 1:2 with various metal ions with divalent and trivalent inorganic molecules like Mn 2+ , Fe 2+ , Cu 2+ , Zn 2+ , Al 3+ , and Fe 3+ .…”

Section: Introductionmentioning

confidence: 99%

“…Because of the highly conjugated ß‐diketone moiety in the chemical structure of curcumin, it can readily form metal chelates of type 1:1 and 1:2 with various metal ions with divalent and trivalent inorganic molecules like Mn 2+ , Fe 2+ , Cu 2+ , Zn 2+ , Al 3+ , and Fe 3+ . This results in the formation of metallocomplexes of curcumin, which may show greater effects as compared to free curcumin . Recent reports have demonstrated that the biochemical activities of curcumin are enhanced by metallocomplexes of curcumin .…”

Section: Introductionmentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Curcumin–Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects

Abstract: This study recognizes higher solubility and stability of Curcumin-Zn(II) complex and suggested better pharmacodynamic effects.

Cited by 41 publications

References 16 publications

Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial

Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Biological properties of metal complexes of curcumin

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