Curcuminoids Lower Plasma Leptin Concentrations: A Meta‐analysis

Abstract

Curcumin is a naturally occurring polyphenol that has been suggested to improve several metabolic diseases. Leptin is an adipokine involved in metabolic status and appetite, with marked crosstalk with other systems. Available data suggest that curcumin may affect leptin levels; therefore, this meta-analysis was performed to evaluate this. A systematic review and meta-analysis were undertaken on all randomized controlled trials of curcumin studies that included the measurement of leptin. The search included PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar databases. Quantitative data synthesis was performed by using a random-effects model, with standardized mean difference and 95% confidence interval as summary statistics. A funnel plot, Begg's rank correlation, and Egger's weighted regression tests assessed the presence of publication bias. Four eligible articles comprising five treatment arms were selected for the meta-analysis. Meta-analysis showed a significant decrease in plasma leptin concentrations following curcumin treatment (standardized mean difference: -0.69, 95% confidence interval: -1.16, -0.23, p = 0.003; I = 76.53%). There was no evidence of publication bias. This meta-analysis showed that curcumin supplementation is associated with a decrease in leptin levels that may be regarded as a potential mechanism for the metabolic effects of curcumin. Copyright © 2017 John Wiley & Sons, Ltd.

Effects of curcumin consumption on human chronic diseases: A narrative review of the most recent clinical data

“…On the basis of the results of these studies, it was found that curcumin consumption exerted a positive effect on weight management of obese individuals, lowering blood lipids and improving glycemic control. This result is in line with a recent meta‐analysis, which showed that curcumin supplementation can lower plasma leptin levels (Atkin, Katsiki, Derosa, Maffioli, & Sahebkar, ), and a systematic review that documented a decrease in fasting glucose levels after 2 hr of oral glucose tolerance test, glycosylated hemoglobin levels A1c, and insulin resistance (HOMA‐IR; Demmers, Korthout, van Etten‐Jamaludin, Kortekaas, & Maaskant, ). Moreover, curcumin administration in patients suffering from various types of cancer, such as prostate, breast, pancreatic, biliary tract, and colon cancer may improve overall health, ameliorating the adverse side effects induced by common pharmaceutical regimens and, in some cases, slowing down disease progression.…”

Polyphenols: A concise overview on the chemistry, occurrence, and human health

“…Curcumin, which represents by alone a constituent (up to ∼5%) of the traditional olistic medicine, is known as turmeric (Nakmareong et al, ; Nelson et al, ). Curcumin exerts a number of pharmacological actions of potential therapeutic interest (Atkin, Katsiki, Derosa, Maffioli, & Sahebkar, ; Kocaadam & Şanlier, ; Mantzorou, Pavlidou, Vasios, Tsagalioti, & Giaginis, ; Milani, Basirnejad, Shahbazi, & Bolhassani, ; Shen, Jiang, Yang, Wang, & Zhu, ; Soleimani, Sahebkar, & Hosseinzadeh, ), and it is extensively marketed worldwide as a nutraceutical (Santini & Novellino, ). Starting from the first clinical trial published in The Lancet in 1937 (Oppenheimer, ), more than 1,200 clinical trials involving more than 6,000 subjects have been carried out, and many systematic reviews have been published (Kunnumakkara et al, ).…”

Curcumin sensitized the antitumour effects of irradiation in promoting apoptosis of oesophageal squamous-cell carcinoma through NF-κB signalling pathway

“…Curcumin is a phyto‐polyphenolic pigment extracted from turmeric ( Curcuma longa ) . It has been widely used for therapeutic purpose histologically due to the intrinsic anti‐inflammatory, antioxidant and antitumour properties . The extensive investigations and exploitations have characterized the wide‐spectrum anticancer activity of curcumin against variety of human tumours including ovarian, breast, colon and so forth .…”

“…[9,10] It has been widely used for therapeutic purpose histologically due to the intrinsic anti-inflammatory, [11,12] antioxidant [13] and antitumour properties. [14][15][16][17][18][19] The extensive investigations and exploitations have characterized the wide-spectrum anticancer activity of curcumin against variety of human tumours including ovarian, breast, colon and so forth. [20][21][22][23][24][25] The various modes of action have been proposed underlying its therapeutic function in treatment of human cancer, including inhibition of proliferation, induction of cell apoptosis and suppression of angiogenesis.…”