Curcuminoids: The Novel Molecules of Nature

Mukherjee, Sitabja; Kar, Sasmita

doi:10.5772/intechopen.99201

Cited by 9 publications

(12 citation statements)

References 59 publications

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“…Curcuminoids are known to inactivate NF-KB and thereby decrease the transcription of pro-inflammatory mediators. In addition, they are capable of modulating the immune response and are promising drug candidates in cancer therapy [ 43 ]. Due to the chemical properties of these compounds, they are not readily bioavailable and are poorly assimilated upon ingestion.…”

Section: Discussionmentioning

confidence: 99%

Effects of Hyperoxia and Hyperoxic Oscillations on the Proteome of Murine Lung Microvascular Endothelium

et al. 2022

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Patients presenting with insufficient tissue oxygenation and impaired lung function as in acute respiratory distress syndrome (ARDS) frequently require mechanical ventilation with supplemental oxygen. Despite the lung being used to experiencing the highest partial pressure of oxygen during healthy breathing, the organ is susceptible to oxygen-induced injury at supraphysiological concentrations. Hyperoxia-induced lung injury (HALI) has been regarded as a second hit to pre-existing lung injury and ventilator-induced lung injury (VILI) attributed to oxidative stress. The injured lung has a tendency to form atelectasis, a cyclic collapse and reopening of alveoli. The affected lung areas experience oxygen conditions that oscillate between hyperoxia and hypoxia rather than remaining in a constant hyperoxic state. Mechanisms of HALI have been investigated in many animal models previously. These studies provided insights into the effects of hyperoxia on the whole organism. However, cell type-specific responses have not been dissected in detail, but are necessary for a complete mechanistic understanding of ongoing pathological processes. In our study, we investigated the effects of constant and intermittent hyperoxia on the lung endothelium from a mouse by an in vitro proteomic approach. We demonstrate that these oxygen conditions have characteristic effects on the pulmonary endothelial proteome that underlie the physiological (patho)mechanisms.

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Section: Discussionmentioning

confidence: 99%

Effects of Hyperoxia and Hyperoxic Oscillations on the Proteome of Murine Lung Microvascular Endothelium

et al. 2022

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“…It is common knowledge that plants are important raw materials and resources for foods and medicines worldwide and that they produce many natural compounds that can affect human health when ingested. , In recent years, numerous studies have examined the bioactivity and nutritional value of various classes of phytochemicals, such as carotenoids, cyanidin, curcuminoids, and stilbenes, quercetin, and naringin . With increasing investigations of PDEVs, several phytochemicals have recently been identified in the cargos of different PDEVs, such as naringin, sulforaphane, curcumin, , shogaol, and gingerol .…”

Section: Characterization and Components Of Pdevsmentioning

confidence: 99%

Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications

Lo,

Wang,

et al. 2024

J. Agric. Food Chem.

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Plant-derived extracellular vesicles (PDEVs) have recently emerged as a promising area of research due to their potential health benefits and biomedical applications. Produced by various plant species, these EVs contain diverse bioactive molecules, including proteins, lipids, and nucleic acids. Increasing in vitro and in vivo studies have shown that PDEVs have inherent pharmacological activities that affect cellular processes, exerting anti-inflammatory, antioxidant, and anticancer activities, which can potentially contribute to disease therapy and improve human health. Additionally, PDEVs have shown potential as efficient and biocompatible drug delivery vehicles in treating various diseases. However, while PDEVs serve as a potential rising star in modern healthy diets and biomedical applications, further research is needed to address their underlying knowledge gaps, especially the lack of standardized protocols for their isolation, identification, and large-scale production. Furthermore, the safety and efficacy of PDEVs in clinical applications must be thoroughly evaluated. In this review, we concisely discuss current knowledge in the PDEV field, including their characteristics, biomedical applications, and isolation methods, to provide an overview of the current state of PDEV research. Finally, we discuss the challenges regarding the current and prospective issues for PDEVs. This review is expected to provide new insights into healthy diets and biomedical applications of vegetables and fruits, inspiring new advances in natural foodbased science and technology.

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“…The synthesis was modified later by Randino and coworkers by using microwave at 100 • C for 4 min with trifluoroacetic acid 100% in solvent-free condition to reach a yield of 10% [29]. Pure CyCur appears as a yellow powder having a melting point between 179 and 226 • C, a boiling point at 571.9 ± 50 • C at 760 mmHg and a density of 1.4 ± 0.1 g/cm 3 [30].…”

Section: Structural and Chemical Propertiesmentioning

confidence: 99%

“…Molecular modeling calculations in association with electron paramagnetic resonance and circular dichroism studies were performed by Randino et al to determine the specific role of the curcuminoids as neuroprotective agents in preventing the formation of the β-amyloid fibrillar aggregates commonly observed in the neurodegenerative diseases [29,[50][51][52][53]. The individual interaction of cyclocurcumin with the β-amyloid fragment Aβ (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) was investigated in hexafluoro-2-propanol/water mixtures and liposomal solutions [54]. Small unilamellar vesicles composed of pure zwitterionic 1,2-dioleoyl-snglycero-3-phosphocholine (DOPC), pure anionic 1,2-dioleoyl-sn-glycero-3-phospho-rac-1-glycerol (DOPG) and DOPC/DOPG in a 90/10 molar ratio mixture were prepared by hydration of the phospholipidic film with phosphate buffer at pH 7.4, followed by sonication.…”

Section: Computational Studiesmentioning

confidence: 99%

Cyclocurcumin as Promising Bioactive Natural Compound: An Overview

Gasbarri,

Angelini

2024

Molecules

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Although identical in molecular formula and weight, curcumin and cyclocurcumin show remarkable differences in their reactivity. Both are natural compounds isolated from the rhizome of turmeric, the former is involved in the diketo/keto-enol tautomerism through the bis-α,β-unsaturated diketone unit according to the polarity of the solvent, while the latter could react by trans-cis isomerization due to the presence of the α,β-unsaturated dihydropyranone moiety. Even if curcumin is generally considered responsible of the therapeutical properties of Curcuma longa L. due to its high content, cyclocurcumin has attracted great interest over the last several decades for its individual behavior and specific features as a bioactive compound. Cyclocurcumin has a hydrophobic nature characterized by fluorescence emission, solvatochromism, and the tendency to form spherical fluorescent aggregates in aqueous solution. Molecular docking analysis reveals the potentiality of cyclocurcumin as antioxidant, enzyme inhibitor, and antiviral agent. Promising biological activities are observed especially in the treatment of degenerative and cardiovascular diseases. Despite the versatility emerging from the data reported herein, the use of cyclocurcumin seems to remain limited in clinical applications mainly because of its low solubility and bioavailability.

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Curcuminoids: The Novel Molecules of Nature

Cited by 9 publications

References 59 publications

Effects of Hyperoxia and Hyperoxic Oscillations on the Proteome of Murine Lung Microvascular Endothelium

Effects of Hyperoxia and Hyperoxic Oscillations on the Proteome of Murine Lung Microvascular Endothelium

Plant-Derived Extracellular Vesicles: A New Revolutionization of Modern Healthy Diets and Biomedical Applications

Cyclocurcumin as Promising Bioactive Natural Compound: An Overview

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