Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway

Yu, Mi; Chen, Xianying; Lv, Chaoyang; Yi, Xilu; Zhang, Yao; Xue, Mengzhou; He, Shunmei; Zhu, Guoying; Wang, Hong-Fu

doi:10.1016/j.bbrc.2014.04.009

Cited by 22 publications

(13 citation statements)

References 32 publications

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“…This agent prevents estrogen deficiency-induced bone loss by inhibiting osteoclastogenesis via the attenuation of JNK and PI3K-Akt signaling [ 87 ]. Curcumol, a sesquiterpene and one of the major components of the essential oil of Rhizoma curcumae with antitumor and anti-inflammatory properties, inhibits osteoclastogenesis by specifically impairing RANKL-induced JNK-activator protein-1 (AP-1) signaling [ 88 ]. In pathological conditions, such as uremic disease, elevated serum phosphate levels are closely related with ectopic extraskeletal calcification, especially in vascular calcification [ 89 ].…”

Section: Jnk Signaling In Osteoclastsmentioning

confidence: 99%

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

Lee

Seo

Choi

et al. 2018

IJMS

187

130

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Bone undergoes continuous remodeling, which is homeostatically regulated by concerted communication between bone-forming osteoblasts and bone-degrading osteoclasts. Multinucleated giant osteoclasts are the only specialized cells that degrade or resorb the organic and inorganic bone components. They secrete proteases (e.g., cathepsin K) that degrade the organic collagenous matrix and establish localized acidosis at the bone-resorbing site through proton-pumping to facilitate the dissolution of inorganic mineral. Osteoporosis, the most common bone disease, is caused by excessive bone resorption, highlighting the crucial role of osteoclasts in intact bone remodeling. Signaling mediated by mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38, has been recognized to be critical for normal osteoclast differentiation and activation. Various exogenous (e.g., toll-like receptor agonists) and endogenous (e.g., growth factors and inflammatory cytokines) stimuli contribute to determining whether MAPKs positively or negatively regulate osteoclast adhesion, migration, fusion and survival, and osteoclastic bone resorption. In this review, we delineate the unique roles of MAPKs in osteoclast metabolism and provide an overview of the upstream regulators that activate or inhibit MAPKs and their downstream targets. Furthermore, we discuss the current knowledge about the differential kinetics of ERK, JNK, and p38, and the crosstalk between MAPKs in osteoclast metabolism.

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Section: Jnk Signaling In Osteoclastsmentioning

confidence: 99%

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

Lee

Seo

Choi

et al. 2018

IJMS

187

130

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“…Similar to curcumin, curcumol also displayed a variety of beneficial pharmacological activities in preclinical studies, including anti-inflammation , anti-rheumatism (Wang et al, 2012;Wang et al, 2014;Yu et al, 2014) and anti-seizure (Ding et al, 2014) and hepato-protection . Moreover, the anti-neoplastic effects of curcumol have been well reported in various cell culture models Zhang et al, 2011;Tian et al, 2012;Jing et al, 2013;Guo et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Curcumol Induces Apoptosis in SPC-A-1 Human Lung Adenocarcinoma Cells and Displays Anti-neoplastic Effects in Tumor Bearing Mice

Tang

Guo²,

Wang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time-and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.

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“…27 In addition, curcumol, another terpene, reduced the osteoclast formation, suppressed receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation through the c-Jun N-terminal kinase (JNK)/activator protein-1 JNK/AP-1 signaling pathway. 28 We believe that αTPN-βCD can act similarly, due to the fact that the treatment with αTPN-βCD reduces the number of osteoclasts per surface area ( Figure 3O).…”

Section: Discussionmentioning

confidence: 89%

Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats

Vasconcelos

Vasconcelos²,

Silva³

et al. 2020

J of Periodontal Research

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Background and objective: This study aimed to assess the effectiveness of the treatment with alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature-induced periodontitis. Material and Methods: Forty female rats were distributed among the following groups: control (vehicle solution), periodontitis (ligature + vehicle solution), 5 mg/kg of αTPN-βCD (ligature), and 25 mg/kg of αTPN-βCD (ligature). Compounds were administered daily via intraperitoneal injection over a 20-day period. Periodontitis was induced with the bilateral insertion of ligatures around the first lower molars of each rat. Oral parameters, as well as blood biomarkers, were measured: histopathological assessment of the hepatic tissue was carried out using light and transmission electron microscopy. Results: The treatment with αTPN-βCD significantly improved several oral parameters and blood biomarkers in comparison with rats with periodontitis. In addition, the treatment with αTPN-βCD significantly ameliorated the steatosis score and reduced the number of lipid droplets and the amount of foamy cytoplasm in the hepatocytes of rats with periodontitis. Conclusion: The results obtained suggest that the treatment with αTPN-βCD improves several oral and blood parameters in rats with experimental periodontitis. In addition, hepatic alterations caused by periodontitis were ameliorated in the rats treated with αTPN-βCD.

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Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway

Cited by 22 publications

References 32 publications

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

Curcumol Induces Apoptosis in SPC-A-1 Human Lung Adenocarcinoma Cells and Displays Anti-neoplastic Effects in Tumor Bearing Mice

Alpha‐terpineol complexed with beta‐cyclodextrin reduces damages caused by periodontitis in rats

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