“…A broad range of drugs have been used to treat Acanthamoeba infections but with various successes. Drugs that show some anti-Acanthamoeba activity include propamidine isethionate, polyhexamethylene biguanide, itraconazole, clotrimazole, pentamidine isethionate, amphotericin B, flucytosine, chlorhexidine gluconate, hydroxystilbamidine, paromomycin, cotrimoxazole, rifampin, polymyxin, sulfadiazine, trimethoprimsulfamethoxazole, azithromycin, dibromopropamidine, hexamidine, and ketoconazole (215,377,401,411,579). In one study, propamidine proved to be the most effective anti-Acanthamoeba agent against 19 corneal isolates (357).…”