Curing of Typhoid Carriers by Cholecystectomy Combined with Amoxycillin plus Probenecid Treatment

Münnich, D; Békési, S

doi:10.1159/000237865

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…Cholecystectomy can be considered if antimicrobials fail, but the surgery can carry risks, and there should be additional indications for operation. The success of surgery for the elimination of chronic carriage is increased by giving antimicrobials at the same time (592).…”

Section: Treatment Of Chronic Carriagementioning

confidence: 99%

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

et al. 2015

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SUMMARY Salmonella enterica infections are common causes of bloodstream infection in low-resource areas, where they may be difficult to distinguish from other febrile illnesses and may be associated with a high case fatality ratio. Microbiologic culture of blood or bone marrow remains the mainstay of laboratory diagnosis. Antimicrobial resistance has emerged in Salmonella enterica , initially to the traditional first-line drugs chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole. Decreased fluoroquinolone susceptibility and then fluoroquinolone resistance have developed in association with chromosomal mutations in the quinolone resistance-determining region of genes encoding DNA gyrase and topoisomerase IV and also by plasmid-mediated resistance mechanisms. Resistance to extended-spectrum cephalosporins has occurred more often in nontyphoidal than in typhoidal Salmonella strains. Azithromycin is effective for the management of uncomplicated typhoid fever and may serve as an alternative oral drug in areas where fluoroquinolone resistance is common. In 2013, CLSI lowered the ciprofloxacin susceptibility breakpoints to account for accumulating clinical, microbiologic, and pharmacokinetic-pharmacodynamic data suggesting that revision was needed for contemporary invasive Salmonella infections. Newly established CLSI guidelines for azithromycin and Salmonella enterica serovar Typhi were published in CLSI document M100 in 2015.

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Section: Treatment Of Chronic Carriagementioning

confidence: 99%

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

et al. 2015

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“…Trimethoprim-sulfamethoxazole has also been used alone or with rifampiein, the results being variable (67). In patients with biliary carriage of Salmonella typhi, removal of the gallbladder has been successful in some patients, but carries the risk of post-operative mortality (68,69). The third generation cephalosporins have shown excellent activity against Salmonella typhi but have not been well investigated in treatment of the typhoid chronic carrier state.…”

Section: Treatment Of Typhoid Carriersmentioning

confidence: 99%

Fluoroquinolones in the treatment of typhoid fever and the carrier state

Trujillo

Quiroz

Gutiérrez

et al. 1991

Eur. J. Clin. Microbiol. Infect. Dis.

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Typhoid fever remains an important public health problem throughout the world with a higher morbidity and mortality rate in the developing countries. Early establishment of the diagnosis and prompt initiation of treatment with chloramphenicol, ampicillin or trimethoprim-sulfamethoxazole is not necessarily followed by complete resolution of the infection. Between 1% and 6% of patients with typhoid fever become chronic biliary carriers of Salmonella typhi. These carriers are potential factors in the continued transmission of the disease. The increasing emergence worldwide of strains showing multiple resistance to the agents traditionally used in therapy has encouraged investigators to seek alternatives such as third generation cephalosporins and recently the new 4-quinolones, which have greater activity against Salmonella typhi including multi-resistant strains. The fluoroquinolones seem to be the treatment of choice in those regions where resistant strains of Salmonella typhi are prevalent.

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Quinolone Antibiotics in the Treatment of Salmonella Infections

Asperilla

Smego

Scott

1990

Clinical Infectious Diseases

116

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Curing of Typhoid Carriers by Cholecystectomy Combined with Amoxycillin plus Probenecid Treatment

Abstract: 11 registered typhoid carriers were treated by cholecystectomy combined with amoxycillin + probenecid in our department. On the basis of our observations (mean observation period was more than 1 year), all our patients can be considered recovered (cure rate = 100%).

Cited by 5 publications

References 8 publications

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

Fluoroquinolones in the treatment of typhoid fever and the carrier state

Quinolone Antibiotics in the Treatment of Salmonella Infections

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