Current advances in the basic research and clinical management of juvenile-onset recurrent respiratory papillomatosis

Bergler, W.; Götte, Karl

doi:10.1007/s004050050236

Cited by 30 publications

(33 citation statements)

References 73 publications

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“…In over 90 types of HPV that are known to date, only a few are linked with malignant transformation. While HPV types 6 and 11 are detected in the majority of exophytic papillomas of the entire upper respiratory tract (40), IPs contain these HPV types in only 6-8% of cases (41). Recent studies using in situ hybridization detected HPV 6 and 11 in 42% of cases.…”

Section: Histopathologymentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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Section: Histopathologymentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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“…Out of more than 90 types of HPV that are known to date, only a few are linked with malignant transformation. While HPV types 6 and 11 are detected in the majority of (benign) exophytic papillomas of the entire upper respiratory tract (reviewed in Bergler and Götte [56]), including the nasal cavity [57], inverted papillomas contain these HPV types in only 6-8% [57,58]. HPV types associated with malignant transformation are, among others, HPV-16 and HPV-18.…”

Section: Nonoccupational Risksmentioning

confidence: 99%

Sinonasal Malignancy: What’s New?

Götte¹,

Hörmann²

2004

ORL

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Tumors of the nasal cavity are located at a complex anatomic site and show a huge histological diversity. Although dealing with a rare malignancy, the last decade has brought – besides new histological and clinical classifications – a variety of new insights into etiological agents, tumor biology and therapeutic concepts as well as valuable overviews of rare histological subtypes. This review tries to disentangle the different medical and scientific aspects of the most frequently encountered histological types of tumors in the nasal cavity and the paranasal sinuses. We concentrate on epidemiology, classification, etiology, cytogenetics and molecular genetics, outcome and prognosis as well as treatment modalities, as far as the past few years have brought considerable new insights. Our principal aim is to provide the clinician with important data from publications of the last decade.

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“…Of the 100 types of HPVs identified, approximately 30 to 40 infect genital tract mucosa and are categorized as either low- or high-risk, the former being associated primarily with benign genital warts, whereas the latter are associated with anogenital cancers, especially cervical cancer [1]. The ability of HPV infections to cause cancer has been attributed to the actions of the E6 and E7 proteins and their ability to manipulate cell cycle regulators such as p53 [2].…”

Section: Introductionmentioning

confidence: 99%

Molecular and Metabolic Consequences Following E6 Transfection in an Isogenic Ovarian Cell Line (A2780) Pair

Chung

Nagy

Zietkowski

et al. 2013

Cell Physiol Biochem

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Aims: To examine molecular and metabolic consequences of HPV-16 viral- protein E6, which targets p53 for degradation, in A2780 (ovarian cancer) cells. Methods: Isogenic derivatives of A2780 cells, with empty-vector (E6-) or E6 (E6+) transfection, were cultured. Intracellular metabolites, fatty acids, and the flux of glutamine, glucose, alanine and lactate in proliferation (Day 2) and confluence (Day 4) were determined using MRS. Western blotting confirmed p53 status, protein expressions related to AKT, ERK and mTOR signalling, and phospholipid metabolism. Results: Growth rate was slower in E6+ cells compared with E6-, resulting in reduced glycolysis, amino acid uptake and fatty acid synthesis. Glutamine metabolism, glycerophosphocholine (GPC), and protein expressions of cytosolic PLA2 (cPLA2) and p-cPLA2 increased in E6+ cells. Despite decreased ERK and AKT signalling, expression of S6RP and p-S6RP downstream of mTOR remained unaffected in E6+ cells. E6+ cells were more invasive and migrate faster than the E6- cells. Conclusion: E6+ had slower growth than E6- cells with reduced metabolism, but E6+ cells maintained cellular homeostasis through glutamine metabolism when compared with E6- at Day 2. The ability to migrate and form larger colonies may provide the E6+ cells with a growth advantage.

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Current advances in the basic research and clinical management of juvenile-onset recurrent respiratory papillomatosis

Cited by 30 publications

References 73 publications

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sinonasal Malignancy: What’s New?

Molecular and Metabolic Consequences Following E6 Transfection in an Isogenic Ovarian Cell Line (A2780) Pair

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