Current Advances in the Biomedical Applications of Quantum Dots: Promises and Challenges

Le, Nhi; Kim, Kyoungtae

doi:10.3390/ijms241612682

Cited by 28 publications

(10 citation statements)

References 136 publications

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“…Their notable optical properties, including broad excitation wavelengths, symmetric emission, high quantum yield, and extended fluorescence, surpass those of traditional fluorophores in sensitivity and clarity. QDs are versatile in labeling a variety of biosystem components including tissues, cells, and molecules for both in vitro and in vivo studies. , Their application in analyzing patient tissues and fluids ex vivo is set to revolutionize our understanding of disease progression and diagnosis.…”

Section: Research Hotspots Of Nanotechnology In Sepsismentioning

confidence: 99%

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Developments and Trends of Nanotechnology Application in Sepsis: A Comprehensive Review Based on Knowledge Visualization Analysis

Fu,

Cai,

Pan

et al. 2024

ACS Nano

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Sepsis, a common life-threatening clinical condition, continues to have high morbidity and mortality rates, despite advancements in management. In response, significant research efforts have been directed toward developing effective strategies. Within this scope, nanotechnology has emerged as a particularly promising field, attracting significant interest for its potential to enhance disease diagnosis and treatment. While several reviews have highlighted the use of nanoparticles in sepsis, comprehensive studies that summarize and analyze the hotspots and research trends are lacking. To identify and further promote the development of nanotechnology in sepsis, a bibliometric analysis was conducted on the relevant literature, assessing research trends and hotspots in the application of nanomaterials for sepsis. Next, a comprehensive review of the subjectively recognized research hotspots in sepsis, including nanotechnology-enhanced biosensors and nanoscale imaging for sepsis diagnostics, and nanoplatforms designed for antimicrobial, immunomodulatory, and detoxification strategies in sepsis therapy, is elucidated, while the potential side effects and toxicity risks of these nanomaterials were discussed. Particular attention is given to biomimetic nanoparticles, which mimic the biological functions of source cells like erythrocytes, immune cells, and platelets to evade immune responses and effectively deliver therapeutic agents, demonstrating substantial translational potential. Finally, current challenges and future perspectives of nanotechnology applications in sepsis with a view to maximizing their great potential in the research of translational medicine are also discussed.

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Section: Research Hotspots Of Nanotechnology In Sepsismentioning

confidence: 99%

“…QDs are versatile in labeling a variety of biosystem components including tissues, cells, and molecules for both in vitro and in vivo studies. 37,38 Their application in analyzing patient tissues and fluids ex vivo is set to revolutionize our understanding of disease progression and diagnosis.…”

Section: Research Hotspots Of Nanotechnology In Sepsismentioning

confidence: 99%

Developments and Trends of Nanotechnology Application in Sepsis: A Comprehensive Review Based on Knowledge Visualization Analysis

Fu,

Cai,

Pan

et al. 2024

ACS Nano

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“…QDs are semiconductor engineering nanomaterials (ENM) with tiny luminescent particles at the nanoscale (typically 2–10 nm in diameter) and are considered as an important choice for traditional fluorescent dyes in biomedical applications. 36 The most classical and common QDs are mainly cadmium containing QDs, such as CdTe, CdS, and CdSe. However, the inherent toxicity of heavy metals Cd limits their practical applicability because they contain dangerous and expensive raw materials.…”

Section: In Vivo Imagingmentioning

confidence: 99%

A Review of in vivo Toxicity of Quantum Dots in Animal Models

Lin,

Chen

2023

IJN

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Tremendous research efforts have been devoted to nanoparticles for applications in optoelectronics and biomedicine. Over the past decade, quantum dots (QDs) have become one of the fastest growing areas of research in nanotechnology because of outstanding photophysical properties, including narrow and symmetrical emission spectrum, broad fluorescence excitation spectrum, the tenability of the emission wavelength with the particle size and composition, anti-photobleaching ability and stable fluorescence. These characteristics are suitable for optical imaging, drug delivery and other biomedical applications. Research on QDs toxicology has demonstrated QDs affect or damage the biological system to some extent, and this situation is generally caused by the metal ions and some special properties in QDs, which hinders the further application of QDs in the biomedical field. The toxicological mechanism mainly stems from the release of heavy metal ions and generation of reactive oxygen species (ROS). At the same time, the contact reaction with QDs also cause disorders in organelles and changes in gene expression profiles. In this review, we try to present an overview of the toxicity and related toxicity mechanisms of QDs in different target organs. It is believed that the evaluation of toxicity and the synthesis of environmentally friendly QDs are the primary issues to be addressed for future widespread applications. However, considering the many different types and potential modifications, this review on the potential toxicity of QDs is still not clearly elucidated, and further research is needed on this meaningful topic.

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“…While various types of ligands have been developed to yield excellent biocompatibility and stability in complex in vivo environments, ,,, their synthesis mostly involves specialized equipment, extensive labor, and complex synthesis techniques. Further, QDs of various compositions are becoming available to cover various wavelength ranges and achieve reduced biotoxicity requiring versatile ligand chemistries that can incorporate various types of metal coordinating groups. − …”

Section: Introductionmentioning

confidence: 99%

Versatile Prepolymer Platform for Controlled Tailoring of Quantum Dot Surface Properties

Lee,

Soares,

Doty

et al. 2024

ACS Appl. Mater. Interfaces

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Quantum dots (QDs) hold immense promise for bioimaging, yet technical challenges in surface engineering limit their wider scientific use. We introduce poly(pentafluorophenyl acrylate) (PPFPA) as a user-friendly prepolymer platform for creating precisely controlled multidentate polymeric ligands for QD surface engineering, accessible to researchers without extensive synthetic expertise. PPFPA combines the benefits of both bottom-up and prepolymer approaches, offering minimal susceptibility to hydrolysis and side reactions for controlled chemical composition, along with simple synthetic procedures using commercially available reagents. Live cell imaging experiments highlighted a significant reduction in nonspecific binding when employing PPFPA, owing to its minimal hydrolysis, in contrast to ligands synthesized by using a conventional prepolymer prone to uncontrolled hydrolysis. This observation underscores the distinct advantage of our prepolymer system. Leveraging PPFPA, we synthesized biomolecule-conjugated QDs and performed QD-based immunofluorescence to detect a cytosolic protein. To effectively label cytosolic targets in such a dense and complex environment, probes must exhibit minimal nonspecific binding and be compact. As a result, QD-immunofluorescence has focused primarily on cell surface targets. By creating compact QD-F(ab′)2, we sensitively detected alpha-tubulin with a ∼50-fold higher signal-to-noise ratio compared to organic dye-based labeling. PPFPA represents a versatile and accessible platform for tailoring QD surfaces, offering a pathway to realize the full potential of colloidal QDs in various scientific applications.

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Current Advances in the Biomedical Applications of Quantum Dots: Promises and Challenges

Cited by 28 publications

References 136 publications

Developments and Trends of Nanotechnology Application in Sepsis: A Comprehensive Review Based on Knowledge Visualization Analysis

Developments and Trends of Nanotechnology Application in Sepsis: A Comprehensive Review Based on Knowledge Visualization Analysis

A Review of in vivo Toxicity of Quantum Dots in Animal Models

Versatile Prepolymer Platform for Controlled Tailoring of Quantum Dot Surface Properties

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