Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review

Li, Fufen; Li, Shan; Liu, Yang; Zhang, Zetian; Li, Zhengjun

doi:10.1002/adem.202101510

Cited by 29 publications

(17 citation statements)

References 219 publications

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“…Among them, PLA is a broadly applicable self-degrading, non-toxic, thermoplastic resin, which is produced from grain. 9 However, due to poor mechanical properties and insufficient hydrophilicity, [10][11][12] PLA polymers have only been able to demonstrate limited application potential. [13][14][15][16] It is known that the polymer blending method is an efficient, economical, and controllable process for polymer modification.…”

mentioning

confidence: 99%

Preparation of PLA/PEG@SDS microfibers‐based nonwovens via melt‐blown process parameters: Wound dressings with enhanced water wetting performance

Wang

Zhang

Cao

et al. 2023

J of Applied Polymer Sci

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Polylactic acid (PLA) melt‐blown nonwovens are promising materials for medical and healthcare applications due to their properties such as softness, breathability, biodegradability, and biocompatibility. However, their widespread commercial application has been limited by their poor mechanical properties and insufficient hydrophilicity limit. To address these limitations, we prepared polylactic acid/polyethylene glycol@sodium dodecyl sulfate (PLA/PEG@SDS) microfibers‐based nonwovens using a melt‐blown process. The average fiber diameter of PLA/PEG@SDS microfibers nonwovens could be tuned from 1 to 13.9 μm by regulating the die temperature or hot air pressure. In addition, increasing the die temperature from 210°C to 225°C resulted in a 140.3% and 124.8% increase in the breaking resistance along the mechanical direction (MD) and transverse direction (CD), respectively. Meanwhile, the increase in the breaking resistance was observed between the hot air pressure and the mechanical strength of the PLA/PEG@SDS microfibers‐based nonwovens. Notably, the prepared samples exhibited a short wetting time of 3.438 s, a fast water absorption rate of 68.401%·s−1, and an excellent liquid water diffusion of 5.86 mm s−1. These results suggest that the PLA/PEG@SDS microfibers nonwovens prepared using melt‐blown process demonstrate efficient wetting performance, which paves the way for the industrial production of medical‐grade materials such as wound dressings.

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confidence: 99%

Preparation of PLA/PEG@SDS microfibers‐based nonwovens via melt‐blown process parameters: Wound dressings with enhanced water wetting performance

Wang

Zhang

Cao

et al. 2023

J of Applied Polymer Sci

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“…Wound dressings made of nanofiber polymers with antibacterial effects and skin regeneration capabilities are good choices for preventing wound infection and speeding wound healing. [183][184][185][186][187][188][189][190][191][192] Antimicrobial agents have been applied to nanofibers to boost their antimicrobial activity. Antimicrobial substances, both inorganic and organic, have been used to achieve this aim.…”

Section: Polymer Advantages and Limitationsmentioning

confidence: 99%

Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

et al. 2022

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Since ancient times, wound dressings have experienced many significant improvements. Evolution began using natural materials to merely cover wounds and advanced to used innovative techniques that can be customized to perform different impressive functions. Recent wound dressings, which are made of electrospun polymers, contain different active compounds, such as antimicrobial agents, that aid in wound healing and prevent dehydration and infection. The mentioned issues may influence the healing process, leading even to serious health risks for the patients. As a result, scientists are now working on novel wound bandages with improved antimicrobial properties. Electrospun polymeric nanofibers, because of their structural similarities to normal skin's extracellular matrix (ECM), bactericidal activity, and appropriateness to distribute bioactive molecules to the wound location, are regarded as good resources for enhancing skin regeneration and controlling wound infection. Herein, the latest findings on approaches for producing antimicrobial polymeric nanofibers using electrospinning and related processes are discussed. Recent advances in antibacterial biopolymeric nanofibers incorporating antimicrobial nanoparticles (silver, zinc oxide, copper oxide, etc.) are discussed. This review paper may raise significant issues, encourage additional research, and offer important insight into the potential area of antibacterial polymeric fibers.

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“…Natural polymers are derived from plant and animal organisms, and they are usually biocompatible, biodegradable, and non-toxic [ 67 ]. Materials of natural or biological origin are the first biodegradable biomaterials used in clinical practice [ 68 ].…”

Section: Natural Polymersmentioning

confidence: 99%

Fabrication of Biodegradable and Biocompatible Functional Polymers for Anti-Infection and Augmenting Wound Repair

Deng

Chen

et al. 2022

Polymers

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The problem of bacteria-induced infections threatens the lives of many patients. Meanwhile, the misuse of antibiotics has led to a significant increase in bacterial resistance. There are two main ways to alleviate the issue: one is to introduce antimicrobial agents to medical devices to get local drug releasing and alleviating systemic toxicity and resistance, and the other is to develop new antimicrobial methods to kill bacteria. New antimicrobial methods include cationic polymers, metal ions, hydrophobic structures to prevent bacterial adhesion, photothermal sterilization, new biocides, etc. Biodegradable biocompatible synthetic polymers have been widely used in the medical field. They are often used in tissue engineering scaffolds as well as wound dressings, where bacterial infections in these medical devices can be serious or even fatal. However, such materials usually do not have inherent antimicrobial properties. They can be used as carriers for drug delivery or compounded with other antimicrobial materials to achieve antimicrobial effects. This review focuses on the antimicrobial behavior, preparation methods, and biocompatibility testing of biodegradable biocompatible synthetic polymers. Degradable biocompatible natural polymers with antimicrobial properties are also briefly described. Finally, the medical applications of these polymeric materials are presented.

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Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review

Cited by 29 publications

References 219 publications

Preparation of PLA/PEG@SDS microfibers‐based nonwovens via melt‐blown process parameters: Wound dressings with enhanced water wetting performance

Preparation of PLA/PEG@SDS microfibers‐based nonwovens via melt‐blown process parameters: Wound dressings with enhanced water wetting performance

Antimicrobial Synthetic and Natural Polymeric Nanofibers as Wound Dressing: A Review

Fabrication of Biodegradable and Biocompatible Functional Polymers for Anti-Infection and Augmenting Wound Repair

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