Current advances on the therapeutic potential of pinocembrin: An updated review

Elbatreek, Mahmoud H.; Mahdi, Ismail; Ouchari, Wafae; Mahmoud, Mona F.; Sobeh, Mansour

doi:10.1016/j.biopha.2022.114032

Cited by 36 publications

(19 citation statements)

References 180 publications

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“…As far as pinocembrin is concerned, several in vitro and preclinical studies have put into light its very favourable antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective and anticancer activities. 82,83…”

Section: Discussionmentioning

confidence: 99%

A novel black poplar propolis extract with promising health-promoting properties: focus on its chemical composition, antioxidant, anti-inflammatory, and anti-genotoxic activities

Acito,

Varfaj,

Brighenti

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

A novel black poplar propolis extract with promising health-promoting properties: focus on its chemical composition, antioxidant, anti-inflammatory, and anti-genotoxic activities

Acito,

Varfaj,

Brighenti

et al. 2024

Food Funct.

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“…Combining flavonols with other anticancer medicines may increase effectiveness and decrease drug resistance. This method might be employed more widely in the future to increase the efficacy of flavonols as anticancer medicines [ 39 , 78 , 151 ]. Furthermore, flavonols may have chemopreventive characteristics, lowering the risk of cancer development.…”

Section: Main Textmentioning

confidence: 99%

Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases

Mahmud

Ema

Siddiquee

et al. 2023

Beni-Suef Univ J Basic Appl Sci

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Background Flavonols are phytoconstituents of biological and medicinal importance. In addition to functioning as antioxidants, flavonols may play a role in antagonizing diabetes, cancer, cardiovascular disease, and viral and bacterial diseases. Quercetin, myricetin, kaempferol, and fisetin are the major dietary flavonols. Quercetin is a potent scavenger of free radicals, providing protection from free radical damage and oxidation-associated diseases. Main body of the abstract An extensive literature review of specific databases (e.g., Pubmed, google scholar, science direct) were conducted using the keywords “flavonol,” “quercetin,” “antidiabetic,” “antiviral,” “anticancer,” and “myricetin.” Some studies concluded that quercetin is a promising antioxidant agent while kaempferol could be effective against human gastric cancer. In addition, kaempferol prevents apoptosis of pancreatic beta-cells via boosting the function and survival rate of the beta-cells, leading to increased insulin secretion. Flavonols also show potential as alternatives to conventional antibiotics, restricting viral infection by antagonizing the envelope proteins to block viral entry. Short conclusion There is substantial scientific evidence that high consumption of flavonols is associated with reduced risk of cancer and coronary diseases, free radical damage alleviation, tumor growth prevention, and insulin secretion improvement, among other diverse health benefits. Nevertheless, more studies are required to determine the appropriate dietary concentration, dose, and type of flavonol for a particular condition to prevent any adverse side effects.

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“…Chemical structure of naturally occurring p38 mitogen‐activated protein kinase inhibitors tanshinone IIA and pinocembrin (which are having suitable physicochemical properties to cross the blood–brain barrier, and some of their important natural sources (Elbatreek et al, 2023; Rasul et al, 2013; Zhang et al, 2012). …”

Section: Potentials Of P38 Mapk Inhibitors Against Cns Complicationsmentioning

confidence: 99%

“…In a study Maione et al (2018) by performing a nongenetic mouse model of amyloid beta-induced Alzheimer's disease report that tanshinone IIA can slow down the course and onset of Alzheimer's disease through its anti-inflammatory and neuroprotective effects. By conducting an animal model of Alzheimer's disease, Jiang et al (2014) reported that tanshinone IIA reduces the risk of Alzheimer's disease by suppressing inducible nitric oxide synthase, F I G U R E 3 Chemical structure of naturally occurring p38 mitogen-activated protein kinase inhibitors tanshinone IIA and pinocembrin (which are having suitable physicochemical properties to cross the blood-brain barrier, and some of their important natural sources (Elbatreek et al, 2023;Rasul et al, 2013;Zhang et al, 2012).…”

Section: Tanshinone Iiamentioning

confidence: 99%

“…A wide range of biological effects has been reported for this dihydroxyflavanone, many of which are exerted through inhibition or modulation of the p38 MAPK pathway (Table 1). In some recent studies, a wide range of biological activities has been reviewed for pinocembrin (Elbatreek et al, 2023;Shen et al, 2019). Due to having remarkable pharmacological activities, such as neuroprotection, antioxidation, and anti-inflammation, this compound has a significant therapeutic potential for the treatment of CNS disorders such as ischemic stroke and various types of neurodegenerative problems probably crosses the BBB through a passive transport process, and P-gp has little effect on its transport process.…”

Section: Pinocembrinmentioning

confidence: 99%

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Therapeutic prospects of naturally occurring p38 MAPK inhibitors tanshinone IIA and pinocembrin for the treatment of SARS‐CoV‐2‐induced CNS complications

Valipour

2023

Phytotherapy Research

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P38 mitogen‐activated protein kinase (p38 MAPK) signaling pathway is closely related to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) replication and hyperinflammatory responses in coronavirus disease 2019 (COVID‐19). Therefore, blood–brain barrier‐penetrating p38 MAPK inhibitors have good potential for the treatment of central nervous system (CNS) complications of COVID‐19. The aim of the present study is the characterization of the therapeutic potential of tanshinone IIA and pinocembrin for the treatment of CNS complications of COVID‐19. Studies published in high‐quality journals indexed in databases Scopus, Web of Science, PubMed, and so forth were used to review the therapeutic capabilities of selected compounds. In continuation of our previous efforts to identify agents with favorable activity/toxicity profiles for the treatment of COVID‐19, tanshinone IIA and pinocembrin were identified with a high ability to penetrate the CNS. Considering the nature of the study, no specific time frame was determined for the selection of studies, but the focus was strongly on studies published after the emergence of COVID‐19. By describing the association of COVID‐19‐induced CNS disorders with p38 MAPK pathway disruption, this study concludes that tanshinone IIA and pinocembrin have great potential for better treatment of these complications. The inclusion of these compounds in the drug regimen of COVID‐19 patients requires confirmation of their effectiveness through the conduction of high‐quality clinical trials.

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Current advances on the therapeutic potential of pinocembrin: An updated review

Cited by 36 publications

References 180 publications

A novel black poplar propolis extract with promising health-promoting properties: focus on its chemical composition, antioxidant, anti-inflammatory, and anti-genotoxic activities

A novel black poplar propolis extract with promising health-promoting properties: focus on its chemical composition, antioxidant, anti-inflammatory, and anti-genotoxic activities

Natural flavonols: actions, mechanisms, and potential therapeutic utility for various diseases

Therapeutic prospects of naturally occurring p38 MAPK inhibitors tanshinone IIA and pinocembrin for the treatment of SARS‐CoV‐2‐induced CNS complications

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