Current algorithms of diagnosis and treatment of multiple sclerosis based on the individual assessment of the patient

Boyko, A. N.; Гусев, Е. И.

doi:10.17116/jnevro20171172292-106

Cited by 24 publications

(2 citation statements)

References 63 publications

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“…Рассеянный склероз (РС) -хроническое прогрессирующее демиелинизирующее заболевание, характеризующееся многоочаговостью поражения центральной нервной системы (ЦНС), в основном возникает в молодом возрасте (от 20 до 40 лет). В последние десятилетия отмечается рост заболеваемости РС среди подростков и детей [1]. Клинически достоверный диагноз РС устанавливается в среднем через 2-3 года после появления первых симптомов, а около половины пациентов к моменту диагностики заболевания больны уже по крайней мере 5 лет [2].…”

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“…Клинически достоверный диагноз РС устанавливается в среднем через 2-3 года после появления первых симптомов, а около половины пациентов к моменту диагностики заболевания больны уже по крайней мере 5 лет [2]. Причинами позднего выявления патологии являются широкая межиндивидуальная вариабельность клинического симптомокомплекса, полиморфизм форм и особенностей течения РС, что связано с его мультифакторной природой [1,3]. Недостаточная информированность врачей, родителей и самих молодых людей также оказывает влияние на сроки выявления заболевания.…”

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Clinical and epidemiological characteristics of multiple sclerosis in students in the Republic of Bashkortostan

Tukhvatullin

Kuzmina

Utyagulova

et al. 2021

RJTAO

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An expansion of the age range of multiple sclerosis (MS) manifestation has been reported recently. Considering the multifactorial etiology, high heterogeneity of the clinical symptoms, and the difficulties of early MS diagnosis in young people, the onset and course of this disease in students can be considered as one of the significant medical and social problems.Objective: to analyze the clinical and epidemiological characteristics of MS in university and secondary specialized educational institutions students in the Republic of Bashkortostan (RB).Patients and methods. This case-control study included 32 patients aged 15 to 24 years studying in universities and secondary schools of the RB. The clinical and epidemiological indicators analysis was carried out based on data from the register of MS patients in the RB. 32 sex-, age-, place of birth and residence-matching patients with MS, who were not students, were included in the control group.Results and discussion. The median age of disease manifestation in students was 18 [16.5; 20] years, in the control group – 16 [14; 19] years (p=0.010). We found a lower «disease onset – diagnosis» in the students group of revealed a lower interval «disease onset – diagnosis» (0.5 [0; 1] years, p=0.006), and a shorter duration of MS compared to the control group ((2.8 [2; 4] years and 4 [2; 7] years, respectively, p=0.020). Students with MS predominantly had movement disorders: central paresis and cerebellar ataxia. Students also had a faster MS progression (0.4 [0.2; 0.6] EDSS scores per year, p=0.001), despite of the disease-modifying therapies.Conclusion. MS manifestation and course in students receiving disease-modifying therapies indicate the need for close follow-up, adherence control, and psychological support in the educational process.

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Clinical and epidemiological characteristics of multiple sclerosis in students in the Republic of Bashkortostan

Tukhvatullin

Kuzmina

Utyagulova

et al. 2021

RJTAO

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Environmental factors and a risk for multiple sclerosis in the Altai Territory

Saldan

Смагина

Ельчанинова

2018

Nevrologiâ, nejropsihiatriâ, psihosomatika

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Multiple sclerosis (MS) is a chronic dysimmune neurodegenerative disease of the central nervous system, the risk of which depends on genetic and environmental factors. The Altai Territory of the Russian Federation shows an increase in the prevalence of MS from 15.5 cases per 100,000population in 1984 to 56.1 in 2017.Objective: to identify potential environmental risk factors for MS in the Altai Territory.Patients and methods. A one-stage randomized study using the method of analytical epidemiology covered 200patients with MS and 200 volunteers without this condition, the representatives of European ethnicity, who were born and lived in the Altai Territory. The investigators surveyed the patients, analyzed their medical records, and assessed the relationship of the prevalence of MS to the characteristics of the territories of residence.Results and discussion. The prevalence of MS was 1.8 times higher in cities and towns than in villages (p=0.003), in areas with heavy metal (lead and molybdenum) ore deposits, chemical and oil refineries located within a 5-km radius from the place of residence. The risk of MS is unassociated with measles, rubella, chicken pox, mumps, whooping cough, herpes infection, chronic nasopharyngeal bacterial infections, diabetes mellitus, allergic status, and contact with household, agricultural, metal, and medicinal poisons, organic solvents, and oil products.Conclusion.The identified environmental risk factors can serve as a basis for recommendations for the prevention of MS in persons at high genetic risk for this disease.

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Experience with anti-B-cell therapy in the pathogenetic treatment of multiple sclerosis

Boyko

Петров²,

Lashch

et al. 2019

Nevrologiâ, nejropsihiatriâ, psihosomatika

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Одним из перспективных направлений патогенетического лечения рассеянного склероза (РС) является анти-В-клеточная терапия с использованием окрелизумаба-моноклонального антитела против CD20-рецептора. Препарат показан при первично-прогрессирующем (ППРС), вторично-прогрессирующем (ВПРС) с обострениями и высокоактивном РС. Цель исследования-анализ применения препарата в условиях повседневной неврологической практики у 32 больных с разными типами течения РС.

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Current algorithms of diagnosis and treatment of multiple sclerosis based on the individual assessment of the patient

Cited by 24 publications

References 63 publications

Clinical and epidemiological characteristics of multiple sclerosis in students in the Republic of Bashkortostan

Clinical and epidemiological characteristics of multiple sclerosis in students in the Republic of Bashkortostan

Environmental factors and a risk for multiple sclerosis in the Altai Territory

Experience with anti-B-cell therapy in the pathogenetic treatment of multiple sclerosis

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