Current and emerging methods for treatment of hemoglobin related cutaneous discoloration: A literature review

Urakov, Aleksandr; Уракова, Н. А.; Nikolenko, Vladimir; Belkharoeva, Rosa; Ачкасов, Е. Е.; Кочурова, Е.В.; Gavryushova, Liliya V.; Sinelnikov, Mikhail Y.

doi:10.1016/j.heliyon.2021.e05954

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…The results confirmed the correctness of the assumption that it is possible to create new drugs from old drugs by artificially and purposefully changing their physical and chemical properties such as temperature, acidity (alkalinity), osmotic, explosive, and oxygen-releasing activity. Examples are new drugs-bleaching stains, traces of blood, bruises, and hematomas, as well as new medical technologies of skin whitening in the area of bruises, developed in Russia on the basis of physical-chemical pharmacology (RU [5,7].…”

Section: Resultsmentioning

confidence: 99%

“…In other words, it is proposed to create new drugs by purposeful changes in the formulation of known drugs providing them with a new mechanism of local action when applied locally. It has been shown that the transformation of drugs known for their general action into drugs with a new mechanism of local action provides a change in their quality indicators and especially in their physicochemical properties [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Targeted Modification of Physical-Chemical Properties of Drugs as a Universal Way to Transform “Old” Drugs into “New” Drugs

Urakov¹,

Уракова²,

Sorokina³

et al. 2023

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

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Historically, the bulk of known drugs was created for resorptive action. Therefore, the mechanism of action of drugs was attributed to the specific action of the main ingredients once they were absorbed into the bloodstream. In recent years, it has been found that the mechanism of local action of drugs is determined not only by the specific activity of their main ingredients but also by the nonspecific activity of the excipients and formulation ingredients included in the ready-to-use drug: tablet, injectable solution, aerosol, etc. In this regard, there is an opportunity to repurpose drugs by purposefully changing their quality by changing the physical, chemical, and physical-chemical properties of the finished products. As an example, two new groups of drugs intended for local application to dissolve dense pus and discolor blood stains, namely, piolytics and drugs that bleach bruises, have been created. It is shown that the advantage and at the same time the limitation of the upgraded preparations is their local application, as their peculiarity is the realization of the physical-chemical principle of the drug action in local interaction with the selected part of the patient’s organism.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted Modification of Physical-Chemical Properties of Drugs as a Universal Way to Transform “Old” Drugs into “New” Drugs

Urakov¹,

Уракова²,

Sorokina³

et al. 2023

Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery

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“…WAHPSs have been reported to consist of the following main ingredients: water, hydrogen peroxide and an alkali (preferably sodium bicarbonate) [20]. Many invented drugs have been shown to be able to dissolve thick masses of pus, blood clots, sulfur plugs, tear stones, mucus, sputum, meconium and other thick biological masses containing the enzyme catalase [23,24]. It has been established that WAHPSs, when locally interacting with sputum, mucus, pus, and serous fluid, are capable of exerting a pyolytic, mucolytic, and antihypoxic oxygen-releasing effect [25][26][27][28][29].…”

Section: Resultsmentioning

confidence: 99%

“…The enrichment of alkaline hydrogen peroxide solutions with oxygen gas or other gases has been shown to increase the pyolytic activity [23]. In addition, local application of WAHPSs has been reported to discolor the skin and nail plate in the area of hematoma and/or bruise, as well as to whiten teeth, dental and ceramic products [8, 24,30]. Consequently, the above data indicate the prospects of repurposing hydrogen peroxide from antiseptics to pyolytics due to a targeted change in the physical and chemical properties.…”

Section: Discussionmentioning

confidence: 99%

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Urakov

Уракова

Решетников

et al. 2023

J. Pharm. Res. Int.

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Pyolytics are drugs that dissolve thick pus when applied topically. This group of drugs was discovered in early 21st century in Russia as a result of successful repurposing of antiseptics hydrogen peroxide, sodium bicarbonate and sodium chloride from antiseptics to pyolytics. Prior to this watershed event in pharmacy, the problem of effective treatment of purulent diseases had not been solved. The fact is that before that in the treatment of various purulent diseases mainly antiseptics and disinfectants solutions were used, of which hypertonic sodium chloride solution and 3 - 6% hydrogen peroxide solutions took the leading role as "antipurulent" drugs. However, the use of the known antiseptics and disinfectants solutions provided disinfection of the treated surface, but not dissolution of thick pus masses, as the solutions had no effective pyolytic action. Pyolytic activity, i.e. activity of dissolution of thick pus masses, was fantastically increased in hydrogen peroxide solutions only after the possibility of transformation of "old" drugs into "new" drugs by means of artificial changes in physical and chemical properties of their dosage forms was discovered. The greatest (explosive) effect was achieved by developing warm alkaline hydrogen peroxide solutions enriched with oxygen gas under increased pressure. In chronological order, an overview is given of Russian inventions, which formed the basis for the physicochemical repurposing of hydrogen peroxide solutions into pyolytics as well as the basis of temperature and physicochemical pharmacology and pharmaceutics.

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“…vascular catheter thrombosis, ischemia, hypoxia, and respiratory obstruction in COVID-19 [35]. In addition, new drugs allow to discolor the skin in the area of bruises, bloody areas of skin and other tissues, skin and nail plate in the area of the hematoma, to whiten teeth, dental and ceramic products [12,13,[14][15][16]31,32,33,34,35]. Therefore, it is necessary to continue research in this direction in order to get more information about the advantages and disadvantages of drugs enriched with gases both with the help of a WAHPS and/or with the help of overpressure of various gases.…”

Section: Discussionmentioning

confidence: 99%

Development of New Generation Drugs by Enriching Them with Gases

Urakov

Shabanov

Lovtsova

2023

J. Pharm. Res. Int.

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Until today, the mechanism of action of drugs is traditionally considered without taking into account the physical-chemical properties of dosage forms. However, at the beginning of the 21st century, there were reports that all drugs contain unaccounted gases that enter drugs from the air and affect the quality of drugs. It is shown that the composition and amount of gases in the dosage forms of all drugs changes their mechanical, physical, chemical and physical-chemical properties and the mechanism of action of drugs, especially when applied topically It is reported that changing the content of gases in drug solutions and tablets allows to regulate their mass, volume, specific gravity, porosity, physico-chemical activity and local action on the routes of drug administration. The identification of this pattern allowed to start the production of completely new drugs with a certain gas composition and with a new local pharmacokinetics and a new local pharmacodynamics. The formulations of new drugs in which gas is an auxiliary, formative or main ingredient are given. It is proposed to control the gas composition of medicines as an indicator of their quality and an important factor of their physical-chemical activity. It is proved that the gas in the drug can be not only neutral, but also auxiliary, oppositional, and sometimes the main ingredient. Thus, the control and accounting of the gas contained in drugs will allow the creation of a new generation of drugs in the near future.

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Current and emerging methods for treatment of hemoglobin related cutaneous discoloration: A literature review

Cited by 16 publications

References 29 publications

Targeted Modification of Physical-Chemical Properties of Drugs as a Universal Way to Transform “Old” Drugs into “New” Drugs

Targeted Modification of Physical-Chemical Properties of Drugs as a Universal Way to Transform “Old” Drugs into “New” Drugs

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Development of New Generation Drugs by Enriching Them with Gases

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