Current and emerging pharmacotherapy for ischemic stroke prevention in patients with atrial fibrillation

Székely, Orsolya; Miyazawa, Kazuo; Lip, Gregory Y. H.

doi:10.1080/14656566.2018.1537368

Cited by 3 publications

(2 citation statements)

References 73 publications

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“…For this reason, the research of new safer and efficient compounds lead to the discovery of a novel VKA, tecarfarin (ATI-5923, Figure 50 ), currently under development [ 195 ]. Tecarfarin is active after oral administration and acts as a vitamin-K epoxide reductase (VKOR) inhibitor; unlike warfarin, is not metabolized by the cytochrome P450 system but by human carboxylesterase-2 ( h CE-2) in hepatic microsomes.…”

Section: Biological Activitiesmentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

283

156

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Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, these natural compounds have been gaining an increasing attention from the scientific community for their wide range of biological activities, mainly due to their ability to interact with diverse enzymes and receptors in living organisms. In addition, coumarin nucleus has proved to be easily synthetized and decorated, giving the possibility of designing new coumarin-based compounds and investigating their potential in the treatment of various diseases. The versatility of coumarin scaffold finds applications not only in medicinal chemistry but also in the agrochemical field as well as in the cosmetic and fragrances industry. This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches.

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Section: Biological Activitiesmentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

283

156

View full text Add to dashboard Cite

show abstract

“…In spite of efficiency in addition with the benefits of an oral treatment, warfarin is not lacking of side-effects used as effective anti-coagulant agent. [37][38].…”

Section: Anticoagulant Activitymentioning

confidence: 99%

Coumarin: A Novel Tool for Multidisciplinary Activities

Jadhav

Adsule

Chabukswar

et al. 2021

JPRI

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Coumarin 2H-1-benzopyran-2-one core has been a field of attention due to its exclusive propensity to accept variable classes of replacements which proves it as the origin for multi-disciplinary activities. Many researchers replicates that coumarin derivatives synthesized by structural modifications & alterations that exhibits diverse pharmacological activities like Anticancer, Carbonic Anhydrase Inhibition, Anti-bacterial, Antifungal, Antiviral, Anticoagulant, Anti Alzheimer activity, Anticonvulsant Activity, Anti-inflammatory etc.The motive of this study is to review, various substituted coumarin derivatives and provide the opportunity of designing & synthesizing novel coumarin based drugs and exploring their possible derivatives in the cure of numerous disorders. This review summerizes the recent development in synthesis of Coumarin based derivatives with various biological activities.

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Factors Affecting the Formation and Treatment of Thrombosis by Natural and Synthetic Compounds

Lichota

Szewczyk

Gwoździński

2020

IJMS

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Venous thromboembolism (VTE) refers to deep vein thrombosis (DVT), whose consequence may be a pulmonary embolism (PE). Thrombosis is associated with significant morbidity and mortality and is the third most common cardiovascular disease after myocardial infarction and stroke. DVT is associated with the formation of a blood clot in a deep vein in the body. Thrombosis promotes slowed blood flow, hypoxia, cell activation, and the associated release of many active substances involved in blood clot formation. All thrombi which adhere to endothelium consist of fibrin, platelets, and trapped red and white blood cells. In this review, we summarise the impact of various factors affecting haemostatic disorders leading to blood clot formation. The paper discusses the causes of thrombosis, the mechanism of blood clot formation, and factors such as hypoxia, the involvement of endothelial cells (ECs), and the activation of platelets and neutrophils along with the effects of bacteria and reactive oxygen species (ROS). Mechanisms related to the action of anticoagulants affecting coagulation factors including antiplatelet drugs have also been discussed. However, many aspects related to the pathogenesis of thrombosis still need to be clarified. A review of the drugs used to treat and prevent thrombosis and natural anticoagulants that occur in the plant world and are traditionally used in Far Eastern medicine has also been carried out.

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Current and emerging pharmacotherapy for ischemic stroke prevention in patients with atrial fibrillation

Cited by 3 publications

References 73 publications

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Coumarin: A Novel Tool for Multidisciplinary Activities

Factors Affecting the Formation and Treatment of Thrombosis by Natural and Synthetic Compounds

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