Current and future directions of drug delivery for the treatment of mental illnesses

Brewster, Parker; Bari, Saif Mohammad Ishraq; Walker, Gregg B.; Werfel, Thomas A.

doi:10.1016/j.addr.2023.114824

Cited by 8 publications

(3 citation statements)

References 163 publications

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“…The etiology of excessive anxiety and depression has been intensively studied over the past few decades; however, the detailed molecular pathways involved remain largely unknown ( Fries et al, 2023 ). Therefore, current medications are generally poorly targeted with highly variable efficacy ( Brewster et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

GABAergic synapses from the ventral lateral septum to the paraventricular nucleus of hypothalamus modulate anxiety

Liu,

Wang,

et al. 2024

Front. Neurosci.

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Emotional disorders, such as anxiety and depression, represent a major societal problem; however, the underlying neurological mechanism remains unknown. The ventral lateral septum (LSv) is implicated in regulating processes related to mood and motivation. In this study, we found that LSv GABAergic neurons were significantly activated in mice experiencing chronic social defeat stress (CSDS) after exposure to a social stressor. We then controlled LSv GABAergic neuron activity using a chemogenetic approach. The results showed that although manipulation of LSv GABAergic neurons had little effect on anxiety-like behavioral performances, the activation of LSv GABAergic neurons during CSDS worsened social anxiety during a social interaction (SI) test. Moreover, LSv GABAergic neurons showed strong projections to the paraventricular nucleus (PVN) of the hypothalamus, which is a central hub for stress reactions. Remarkably, while activation of GABAergic LSv–PVN projections induced social anxiety under basal conditions, activation of this pathway during CSDS alleviated social anxiety during the SI test. On the other hand, the chemogenetic manipulation of LSv GABAergic neurons or LSvGABA–PVN projections had no significant effect on despair-like behavioral performance in the tail suspension test. Overall, LS GABAergic neurons, particularly the LSv GABAergic–PVN circuit, has a regulatory role in pathological anxiety and is thus a potential therapeutic target for the treatment of emotional disorders.

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Section: Introductionmentioning

confidence: 99%

GABAergic synapses from the ventral lateral septum to the paraventricular nucleus of hypothalamus modulate anxiety

Liu,

Wang,

et al. 2024

Front. Neurosci.

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“…The control of the kinetics of drug release is one of the most challenging fields in pharmaceutics and drug delivery research [1,2]. Several drug release triggers such as pH, ionic strength, temperature, diffusion and degradation processes have been largely investigated with the purpose of controlling the kinetics of drug delivery mechanisms [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Hyperthermic triggers for drug delivery platforms

Alarcón-Segovia,

Morel,

Daza-Agudelo

et al. 2023

Nanotechnology

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Electromagnetic fields can penetrate aqueous media in a homogeneous and instantaneous way, without physical contact, independently of its temperature, pressure, agitation degree and without modifying their chemical compositions nor heat and mass transfer conditions. In addition, superparamagnetic biomaterials can interact with electromagnetic fields by absorbing electromagnetic energy and transforming it in localized heat with further diffusion to surrounding media. This paper is devoted to the exploration of the potential use of hyperthermic effects resulting from the interaction between externally applied electromagnetic fields and superparamagnetic nanoparticles as a trigger for controlled drug release in soft tissue simulating materials. Gelatin based soft tissue simulating materials were prepared and doped with superparamagnetic nanoparticles. The materials were irradiated with externally applied electromagnetic fields. The effects on temperature and diffusion of a drug model in water and phosphate buffer were investigated. Significant hyperthermic effects were observed. The temperature of the soft tissue simulating material resulted increased from 35°C to 45°C at 2.5 °C/min. Moreover, the release of an entrapped model drug reached 89%. The intensity of the hyperthermic effects was found to have a strong dependency on the concentration of superparamagnetic nanoparticles and the power and the pulse frequency of the electromagnetic field.

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“…There are many various types of mental illnesses such as depression, schizophrenia, dementia, autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), etc. (Brewster et al, 2023). Statistics suggested that approximately 33% of individuals would experience at least one mental illness during their lifetime (Marin et al, 2023).…”

mentioning

confidence: 99%

The effect of mindfulness‐based interventions on mental health outcomes and wellbeing of informal caregivers of people with mental illness: A systematic review and meta‐analysis

Zhang,

Ren,

Wang

et al. 2024

Int J Mental Health Nurs

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The increasing prevalence of mental illness has resulted in a growing burden on informal caregivers. Mindfulness‐based interventions, as a form of psychotherapy, have shown efficacy in alleviating psychological stress and enhancing emotional and physical well‐being. However, the utilisation of mindfulness‐based interventions for informal caregivers of individuals with mental illness remains limited. The aim of the meta‐analysis is to evaluate the impact of mindfulness‐based interventions on the mental health and well‐being among informal caregivers of people with mental illness. A comprehensive literature search was conducted across seven electronic databases (PubMed, Scopus, Web of Science, Cochrane Library, Embase, APA PsycINFO and CINAHL Ultimate) from the inception of these databases until 20 July 2023. Two authors independently screened the studies and extracted the relevant data. The meta‐analysis was performed by using Stata 12.0 software, and the effect sizes were calculated utilising standardised mean difference (SMD) along with their corresponding 95% confidence intervals (CI). The meta‐analysis included 13 studies with 1007 participants, and the results demonstrated that mindfulness‐based interventions were efficacious in reducing stress (SMD = −0.80, 95% CI [−1.33, −0.28], p = 0.003), depression (SMD = −0.43, 95% CI [−0.62, −0.24], p < 0.001) and caregiver burden (SMD = −0.21, 95% CI [−0.40, −0.01], p = 0.038), and enhancing the mindfulness level (SMD = 0.37, 95% CI [0.09, 0.65], P = 0.010) and quality of life (SMD = 0.22, 95% CI [0.04, 0.39], p = 0.015) among informal caregivers of people with mental illness, but not on anxiety reduction (SMD = −0.19, 95% CI [−0.49, 0.10], p = 0.198). Furthermore, future research should aim to employ more rigorous methodologies to confirm the effectiveness.

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Current and future directions of drug delivery for the treatment of mental illnesses

Cited by 8 publications

References 163 publications

GABAergic synapses from the ventral lateral septum to the paraventricular nucleus of hypothalamus modulate anxiety

GABAergic synapses from the ventral lateral septum to the paraventricular nucleus of hypothalamus modulate anxiety

Hyperthermic triggers for drug delivery platforms

The effect of mindfulness‐based interventions on mental health outcomes and wellbeing of informal caregivers of people with mental illness: A systematic review and meta‐analysis

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