Current and Future Lymphatic Imaging Modalities for Tumor Staging

Murtaza, Ghulam; Gao, Kuo; Liu, Tiegang; Tariq, Imran; Sajjad, Ashif; Akram, Muhammad; Niu, Meiying; Liu, Guokai; Mehmood, Zahid; Tian, Guihua

doi:10.1155/2014/714674

Cited by 3 publications

(3 citation statements)

References 96 publications

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“…So-called sentinel lymph nodes (SLNs) are found in close distance to tumours and thus represent a gate for metastasis. 427 Mapping of SLNs is important for assessing the stage of cancer and for planning an efficient treatment. Different studies showed the possibility of SLN mapping using NIR-QDs [428][429][430][431][432] and demonstrated the possibility for an imageguided surgery for the resection of SLNs.…”

Section: These Results Demonstrated the Importance Of Appropriatementioning

confidence: 99%

Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors

2015

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Semiconductor quantum dots (QDs) have become important fluorescent probes for in vitro and in vivo bioimaging research. Their nanoparticle surfaces for versatile bioconjugation, their adaptable photophysical properties for multiplexed detection, and their superior stability for longer investigation times are the main advantages of QDs compared to other fluorescence imaging agents. Here, we review the recent literature dealing with the design and application of QD-bioconjugates for advanced in vitro and in vivo imaging. After a short summary of QD preparation and their most important properties, different QD-based imaging applications will be discussed from the technological and the biological point of view, ranging from super-resolution microscopy and single-particle tracking over in vitro cell and tissue imaging to in vivo investigations. A substantial part of the review will focus on multifunctional applications, in which the QD fluorescence is combined with drug or gene delivery towards theranostic approaches or with complementary technologies for multimodal imaging. We also briefly discuss QD toxicity issues and give a short outlook on future directions of QD-based bioimaging.

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Section: These Results Demonstrated the Importance Of Appropriatementioning

confidence: 99%

Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors

2015

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“…For example, 99MTC labelled liposomes for lymph node imaging. [34] Infections and their treatment: Infections are very diverse and caused by bacteria, fungi, parasites, viruses, etc. Beneficial effect is seen with lymphatic targeting because, viruses like HIV and parasites mainly reside in lymph nodes and lymph vessels.…”

Section: Applicationsmentioning

confidence: 99%

Lymphatic System: A Path for Drug Delivery

Sunkari¹,

Sunduru²

2020

IJAPB

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A Lymphatic system is a network like system being extended all over the body and useful targets for efficient drug delivery for drugs having poor oral bioavailability in the intestine and less absorbed into systemic circulation because of drug degradation in GI tract. Lymphatic targeting is not only to treat various infections not limited to pathological conditions like human immunodeficiency virus and other diseases but also used in diagnosis of tumours along with metastasis. Moreover, lymph nodes are the site for faster spread source to tumours via metastasis. Under these circumstances, there is a need for effective delivery of drugs towards and through lymphatic networks. Nano based systems and lipid based systems have unique features as necessary candidates for lymphatic delivery. The review provides information about different routes, drug transport in the lymphatic system, physicochemical properties which give impact on lymphatic delivery.

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“…There are evidences that the oxidative stress in the central and peripheral nervous system (CECCHI et al, 2002;MOREIRA et al, 2007a) is responsible for mitochondrial dysfunction (MD) (BONDA et al, 2010a). It results in the development of various neurodegenerative disorders (AVILA, 2010), including AD (ZHU et al, 2013;MURTAZA et al, 2014) that can be categorized into two types: familial Alzheimer's disease (FAD) and sporadic Alzheimer's disease (SAD) (Table 2). FAD is found to be originated from mutations in at least one of the three genes recognized as amyloid precursor protein (APP) and presenilin-1 and -2(ps-1 and ps-2) (PRICE et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Genetic and non-genetic factors responsible for mitochondrial failure and Alzheimer’s disease

et al. 2014

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The objective of this review article is to explain the factors responsible for damaged mitochondria and its association with Alzheimer?s disease. Alzheimer?s disease (AD) is fairly produced by dysfunctional mitochondria that are alternatively caused by excessive reactive oxygen species and mitochondrial dynamic imbalance. In the pathogenesis of AD, there is important role of many factors including amyloid-beta peptide (A ), tau-proteins, and mutations in presenilin-1. Additionally, mitochondrial-targeted antioxidants have also been explained because of their significance to mitochondrial alterations in AD. Moreover, alteration in mitochondrial dynamics is responsible for the generation of segregated, damaged mitochondria that are, later on, destroyed through mitochondrial autophagy in AD. Finally, various novel models used for studying Alzheimer?s disease, have been discussed.

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Current and Future Lymphatic Imaging Modalities for Tumor Staging

Cited by 3 publications

References 96 publications

Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors

Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors

Lymphatic System: A Path for Drug Delivery

Genetic and non-genetic factors responsible for mitochondrial failure and Alzheimer’s disease

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