Current and future options of regeneration methods and reconstructive surgery of the facial skeleton

Götz, Carolin; Warnke, Patrick H.; Kolk, Andreas

doi:10.1016/j.oooo.2015.05.022

Cited by 22 publications

(22 citation statements)

References 87 publications

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“…1 In the case of large-scale tissue loss, for example following tumour or trauma surgery (Figure 1), the defects can be restored by the use of individualized permanent implants ( Figure 1). When damage is greater than certain dimensions, surgeons mainly use titanium implants for permanent use (Figure 1), despite their known disadvantages, including high cost, weight, artefacts in CT, and MRI scanning and sensitivity to temperature.…”

Section: Introductionmentioning

confidence: 99%

“…The development of alternatives to autogenous bone replacement in the facial skeleton, such as scaffolds (SCs) with a bone-like interconnecting porous system, is one of the most difficult and necessary challenges in the combinational field of surgery and tissue engineering. 1,2 SCs have to possess various characteristics and biomechanical properties in order to match the bony host tissue, with a bone-like interconnecting porous system for vascular ingrowth, cell migration, and biocompatibility. [1][2][3] At the beginning of the 1960s, polymers came to the attention of orthopedic surgeons.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 SCs have to possess various characteristics and biomechanical properties in order to match the bony host tissue, with a bone-like interconnecting porous system for vascular ingrowth, cell migration, and biocompatibility. [1][2][3] At the beginning of the 1960s, polymers came to the attention of orthopedic surgeons. 4 The degradation of these polymers has been widely investigated in vitro 5 and in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…1,13 These are: Gradients of porous (spongy) surface areas for the improvement of ingrowth behavior. Complex 3D geometries and excellent mechanical properties for optimal adjustment of the implant to bone damage.…”

Section: Introductionmentioning

confidence: 99%

“…One cost-effective fabrication process is the additive production method of SLM. 1,8 In brief, the SLM process allows the generation of nearly any complex structural element straight from the 3D CAD model without the use of a shaping tool, because the structural element is built-up in layers on a powder base. In case of a SC the vast advantage of this SLM process is the predictable pore network orientation and microporosity.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction:In vitroandin vivoresults

Smeets

Barbeck

Hanken

et al. 2016

J. Biomed. Mater. Res.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction:In vitroandin vivoresults

Smeets

Barbeck

Hanken

et al. 2016

J. Biomed. Mater. Res.

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A novel nonviral gene delivery tool of BMP‐2 for the reconstitution of critical‐size bone defects in rats

Kolk

Tischer

Koch

et al. 2016

J Biomedical Materials Res

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The osseointegration of bone implants, implant failure, and the bridging of critical-size bone defects are frequent clinical challenges. Deficiencies in endogenous bone healing can be resolved through the local administration of suitable recombinant growth factors (GFs). In preclinical models, gene-therapy-supported bone healing has proven promising for overcoming certain limitations of GFs. We report the dose-dependent bridging of critical-size mandibular bone defects (CSDs) in a rat model using a non-viral BMP-2-encoding copolymer-protected gene vector (pBMP-2) embedded in poly(d, l-lactide) (PDLLA) coatings on titanium discs that were used to cover drill holes in the mandibles of 53 male Sprague Dawley rats. After sacrificing, the mandibles were subjected to micro-computed tomography (µCT), micro-radiography, histology, and fluorescence analyses to evaluate bone regeneration. pBMP-2 in PDLLA-coated titanium implants promoted partial bridging of bone defects within 14 days and complete defect healing within 112 days when the DNA dose per implant did not exceed 2.5 µg. No bridging was observed in untreated control CSDs. Thus, the delivery of plasmid DNA coding for BMP-2 appears to be a potent method for controlled new-bone formation with an inverse dose dependency. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2441-2455, 2016.

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Alveolar bone tissue engineering in critical-size defects of experimental animal models: a systematic review and meta-analysis

Shanbhag

Pandis

Mustafa

et al. 2016

J Tissue Eng Regen Med

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Regeneration of large, 'critical-size' bone defects remains a clinical challenge. Bone tissue engineering (BTE) is emerging as a promising alternative to autogenous, allogeneic and biomaterial-based bone grafting. The objective of this systematic review was to answer the focused question: in animal models, do cell-based BTE strategies enhance regeneration in alveolar bone critical-size defects (CSDs), compared with grafting with only biomaterial scaffolds or autogenous bone? Following PRISMA guidelines, electronic databases were searched for controlled animal studies reporting maxillary or mandibular CSD and implantation of mesenchymal stem cells (MSCs) or osteoblasts (OBs) seeded on biomaterial scaffolds. A random effects meta-analysis was performed for the outcome histomorphometric new bone formation (%NBF). Thirty-six studies were included that reported on large- (monkeys, dogs, sheep, minipigs) and small-animal (rabbits, rats) models. On average, studies presented with an unclear-to-high risk of bias and short observation times. In most studies, MSCs or OBs were used in combination with alloplastic mineral-phase scaffolds. In five studies, cells were modified by ex vivo gene transfer of bone morphogenetic proteins (BMPs). The meta-analysis indicated statistically significant benefits in favour of: (1) cell-loaded vs. cell-free scaffolds [weighted mean difference (WMD) 15.59-49.15% and 8.60-13.85% NBF in large- and small-animal models, respectively]; and (2) BMP-gene-modified vs. unmodified cells (WMD 10.06-20.83% NBF in small-animal models). Results of cell-loaded scaffolds vs. autogenous bone were inconclusive. Overall, heterogeneity in the meta-analysis was high (I > 90%). In summary, alveolar bone regeneration is enhanced by addition of osteogenic cells to biomaterial scaffolds. The direction and estimates of treatment effect are useful to predict therapeutic efficacy and guide future clinical trials of BTE. Copyright © 2016 John Wiley & Sons, Ltd.

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Current and future options of regeneration methods and reconstructive surgery of the facial skeleton

Cited by 22 publications

References 87 publications

Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction:In vitroandin vivoresults

Selective laser-melted fully biodegradable scaffold composed of poly(d,l-lactide) and β-tricalcium phosphate with potential as a biodegradable implant for complex maxillofacial reconstruction:In vitroandin vivoresults

A novel nonviral gene delivery tool of BMP‐2 for the reconstitution of critical‐size bone defects in rats

Alveolar bone tissue engineering in critical-size defects of experimental animal models: a systematic review and meta-analysis

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