Current and future technological advances in transdermal gene delivery

Chen, Xianfeng

doi:10.1016/j.addr.2017.12.014

Cited by 60 publications

(35 citation statements)

References 189 publications

(170 reference statements)

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“…In addition, researchers also took the advantages of laser and another microdermabrasion device to facilitate insulin transport through the skin [246][247][248]. Besides, transdermal strategies such as power jet, heat or magnetophoresis-assisted administration routes could also be investigated for needless delivery of insulin [137,249].…”

Section: Discussionmentioning

confidence: 99%

Advances in transdermal insulin delivery

Zhang

Kahkoska

et al. 2019

Advanced Drug Delivery Reviews

241

112

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Insulin therapy is necessary to regulate blood glucose levels for people with type 1 diabetes and commonly used in advanced type 2 diabetes. Although subcutaneous insulin administration via hypodermic injection or pump-mediated infusion is the standard route of insulin delivery, it may be associated with pain, needle phobia, and decreased adherence, as well as the risk of infection. Therefore, transdermal insulin delivery has been widely investigated as an attractive alternative to subcutaneous approaches for diabetes management in recent years. Transdermal systems designed to prevent insulin degradation and offer controlled, sustained release of insulin may be desirable for patients and lead to increased adherence and glycemic outcomes. A challenge for transdermal insulin delivery is the inefficient passive insulin absorption through the skin due to the large molecular weight of the protein drug. In this review, we focus on the different transdermal insulin delivery techniques and their respective advantages and limitations, including chemical enhancerspromoted, electrically enhanced, mechanical force-triggered, and microneedle-assisted methods.

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Section: Discussionmentioning

confidence: 99%

Advances in transdermal insulin delivery

Zhang

Kahkoska

et al. 2019

Advanced Drug Delivery Reviews

241

112

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“…Further changes to the type of drug reservoir may also further enhance delivery of metformin HCl. Hydrogel-forming MNs are clearly a promising technology that could be used to enhance transdermal delivery of a range of therapeutic substances [ 31 ]. The aim of this study was to establish preliminary data to investigate the potential for transdermal delivery of metformin HCl by hydrogel-forming MNs.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride

Migdadi

Courtenay

Tekko

et al. 2018

Journal of Controlled Release

207

142

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We investigated, for the first time, the potential for a hydrogel-forming microneedle (MN) patch to deliver the high-dose drug metformin HCl transdermally in a sustained manner. This may minimize some gastrointestinal side effects and small intestine absorption variations associated with oral delivery. Patches (two layers) were assembled from a lyophilised drug reservoir layer, with the MN layer made from aqueous blend of 20% w/w poly (methylvinylether-co-maleic acid) crosslinked by esterification with 7.5% w/w poly (ethylene glycol) 10,000 Da. >90% of metformin was recovered from homogeneous drug reservoirs. Drug reservoir dissolution time in PBS (pH 7.4) was <10 min. MN penetrated a validated skin model Parafilm® M consistently. Permeation of metformin HCl across dermatomed neonatal porcine skin in vitro was enhanced by using MN. The combined MN and metformin HCl reservoir patch (containing 75 mg or 50 mg metformin HCl, respectively) delivered 9.71 ± 2.22 mg and 10.04 ± 1.92 mg at 6 h, respectively, and 28.15 ± 2.37 mg and 23.25 ± 3.58 mg at 24 h, respectively.In comparison, 0.34 ± 0.39 mg and 0.85 ± 0.68 mg was delivered at 6 h, respectively, and 0.39 ± 0.39 mg and 1.01 ± 0.84 mg was delivered at 24 h, respectively, from a control set-up employing only the drug reservoirs. In vivo, metformin HCl was detected in rat plasma at 1 h post MN application at a concentration of 0.62 ± 0.51 μg/mL, increasing to 3.76 ± 2.58 μg/ml at 3 h. A maximal concentration of 3.77 ± 2.09 μg/ml was achieved at 24 h. Css was 3.2 μg/mL. Metformin transdermal bioavailability using MNs was estimated as 30%.Hydrogel-forming MN are a promising technology that has demonstrated successful transdermal delivery of metformin HCl. Potential clearly exists for administration of other high-dose drugs using this system.

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“…Skin is the first physiological barrier of the human body and is also the largest organ (29). It not only protects the body from adverse external factors, but also prevents loss of moisture and nutrients, and plays essential roles in defense (30).…”

Section: Discussionmentioning

confidence: 99%

“…It not only protects the body from adverse external factors, but also prevents loss of moisture and nutrients, and plays essential roles in defense (30). Moreover, skin is one of the primary locations for drug metabolism, in addition to the liver (29). The 'cocktail' probe substrates approach method has the advantages of high throughput, rapidity and simplicity, and it can reduce the influence of individual differences on the experimental results (31).…”

Section: Discussionmentioning

confidence: 99%

Influence of a combination of triptolide and ferulic acid on the activities of CYP450 enzymes and oxidative stress in HaCaT cells

Zhang

Guan

et al. 2020

Exp Ther Med

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Topical administration of triptolide (TP) is effective in the treatment of rheumatoid arthritis (RA), but it can also induce skin irritation. Previous studies have used data mining strategies to analyze the application of Tripterygium wilfordii in the treatment of RA and have shown that TP and ferulic acid (FA) can be used in combination due to their component compatibility. The aims of the present study were to investigate the mechanisms underlying the effects of TP treatment and to identify its effects on metabolism and oxidative damage in the skin. MTT assay results suggested that the HaCaT cell survival rate was significantly increased when the compatibility ratio of TP to FA was 1:100. Moreover, the combination of TP with FA (TP + FA) did not significantly affect the activities of the cytochrome P40 (CYP) enzymes CYP family 1 subfamily A member 2 (CYP1A2), CYP2E1 and CYP3A4, when used as a 'cocktail'. It was found that TP + FA significantly decreased the production levels of reactive oxygen species (ROS), superoxide dismutase and malondialdehyde in HaCaT cells, while significantly increasing levels of glutathione and catalase. In addition, TP + FA significantly increased nuclear factor erythroid 2-related factor 2 protein expression, compared with TP alone. Thus, the present results indicated that the underlying mechanism of TP + FA efficacy may be related to decreased ROS production level in HaCaT cells, increased production levels of key antioxidant factors and increased antioxidant activity of the epidermis, all of which were correlated with a protective effect against oxidative damage.

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Current and future technological advances in transdermal gene delivery

Cited by 60 publications

References 189 publications

Advances in transdermal insulin delivery

Advances in transdermal insulin delivery

Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride

Influence of a combination of triptolide and ferulic acid on the activities of CYP450 enzymes and oxidative stress in HaCaT cells

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