Current Application of Mass Spectrometry to Combinatorial Chemistry

Cheng, Xueheng; Hochlowski, Jill E.

doi:10.1021/ac020186f

Cited by 46 publications

(24 citation statements)

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“…These are important methods in drug research and the characterization of the "libraries" obtained, containing thousands of compounds, including identification of synthesized compounds, is a very special field of drug analysis [43]. The most widely-used methods for this purpose are MS [43][44][45] and NMR spectroscopy [43,46], coupled to HPLC.…”

Section: Synthetic Productsmentioning

confidence: 99%

Identification in drug quality control and drug research

Gǒrög

2015

TrAC Trends in Analytical Chemistry

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Section: Synthetic Productsmentioning

confidence: 99%

Identification in drug quality control and drug research

Gǒrög

2015

TrAC Trends in Analytical Chemistry

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“…[35] Since then HTS has mainly stayed a field of research applied to and developed for parallel catalyst design [83,84] and drug discovery. [85,86] There are only a few examples where HTS is applied to synthetic polymers in order to obtain information about molecular weight, optical properties, morphology, etc. [17,39] The existing techniques will be the subject of discussion in the following paragraphs.…”

Section: High-throughput Characterization Of Polymersmentioning

confidence: 99%

Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present

Hoogenboom

Meier

Schubert

2003

Macromol. Rapid Commun.

204

160

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Combinatorial techniques, parallel experimentation and high‐throughput methods represent a very promising approach in order to speed up the preparation and investigation of new polymeric materials: a large variety of parameters can be screened simultaneously resulting in new structure/property relationships. The field of polymer research seems to be perfectly suited for parallel and combinatorial methods due to the fact that many parameters can be varied during synthesis, processing, blending as well as compounding. In addition, numerous important parameters have to be investigated, such as molecular weight, polydispersity, viscosity, hardness, stiffness and other application‐specific properties. A number of corresponding high‐throughput techniques have been developed in the last few years and their introduction into the commercial market further boosted the development. These combinatorial approaches can reduce the time‐to‐market for new polymeric materials drastically compared to traditional approaches and allow a much more detailed understanding of polymers from the macroscopic to the nanoscopic scale. Here we provide an overview of the present status of combinatorial and parallel polymer synthesis and high‐throughput screening.magnified image

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“…The business of drug discovery was also changing during this time from synthesis of one compound at a time to the adoption of combinatorial or parallel synthesis chemistry strategies [7] often yielding mixtures of compounds requiring identification and purification. This led to an increased demand for high throughput flow injection analysis (HTP FIA) and LC/MS, in addition to the development of mass-guided LC/MS systems for automated purification.…”

Section: Background On Chemical Synthesis Supportmentioning

confidence: 99%