Current Approaches for Exploration of Nanoparticles as Antibacterial Agents

Karaman, Didem Şen; Manner, Suvi; Fallarero, Adyary; Rosenholm, Jessica M.

doi:10.5772/68138

Cited by 28 publications

(32 citation statements)

References 141 publications

(170 reference statements)

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“…Among these, Ag NPs are the most effective as they are able to kill both Gram-positive and Gram-negative bacteria, and they are even effective against drug-resistant species [ 16 ]. Moreover, metal oxide NPs, such as Ag 2 O, ZnO, CuO, TiO 2 , NiO, Fe 3 O 4 , α-Fe 2 O 3 , CaO, MgO, Al 2 O 3 , CeO 2 , Mn 3 O 4 , and ZrO 2 NPs, have highly potent antibacterial effects against a wide spectrum of microorganisms [ 17 ]. Similarly, metal sulfide and metal–organic framework (MOF) nanomaterials, such as AgS-, FeS-, CdS-, and ZnS-MOFs and Mn-, Cu-, and Zn-based MOFs, have demonstrated antimicrobial activities [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives

Basavegowda

Baek

2021

Molecules

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Recently, infectious diseases caused by bacterial pathogens have become a major cause of morbidity and mortality globally due to their resistance to multiple antibiotics. This has triggered initiatives to develop novel, alternative antimicrobial materials, which solve the issue of infection with multidrug-resistant bacteria. Nanotechnology using nanoscale materials, especially multimetallic nanoparticles (NPs), has attracted interest because of the favorable physicochemical properties of these materials, including antibacterial properties and excellent biocompatibility. Multimetallic NPs, particularly those formed by more than two metals, exhibit rich electronic, optical, and magnetic properties. Multimetallic NP properties, including size and shape, zeta potential, and large surface area, facilitate their efficient interaction with bacterial cell membranes, thereby inducing disruption, reactive oxygen species production, protein dysfunction, DNA damage, and killing potentiated by the host’s immune system. In this review, we summarize research progress on the synergistic effect of multimetallic NPs as alternative antimicrobial agents for treating severe bacterial infections. We highlight recent promising innovations of multimetallic NPs that help overcome antimicrobial resistance. These include insights into their properties, mode of action, the development of synthetic methods, and combinatorial therapies using bi- and trimetallic NPs with other existing antimicrobial agents.

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Section: Introductionmentioning

confidence: 99%

Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives

Basavegowda

Baek

2021

Molecules

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“…The antimicrobial effects of AgNPs are accomplished by a unique physiochemical property which allows for a large surface area to volume ratio, generating more efficient contact with microorganisms and enhancing interactions with microbial proteins [16,17]. This has garnered much success on an antibacterial platform, allowing for potential alternatives to antibiotic-resistant strains of bacteria, improved wound healing, and antibacterial coatings for medical materials, such as stents, catheters and orthopedic implants [18,19]. AgNPs have also demonstrated promising antiviral capabilities with viruses, such as HIV, Tacaraibe virus, and several respiratory pathogens, including adenovirus, parainfluenza and influenza (H3N2) [20,21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection

Morris

Ansar

Speshock

et al. 2019

Viruses

179

126

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Respiratory syncytial virus (RSV) is an important etiological agent of respiratory infection in children for which no specific treatment option is available. The RSV virion contains two surface glycoproteins (F and G) that are vital for the initial phases of infection, making them critical targets for RSV therapeutics. Recent studies have identified the broad-spectrum antiviral properties of silver nanoparticles (AgNPs) against respiratory pathogens, such as adenovirus, parainfluenza, and influenza. AgNPs achieve this by attaching to viral glycoproteins, blocking entry into the host cell. The objective of this study was to evaluate the antiviral and immunomodulatory effects of AgNPs in RSV infection. Herein we demonstrate AgNP-mediated reduction in RSV replication, both in epithelial cell lines and in experimentally infected BALB/c mice. Marked reduction in pro-inflammatory cytokines (i.e., IL-1α, IL-6, TNF-α) and pro-inflammatory chemokines (i.e., CCL2, CCL3, CCL5) was also observed. Conversely, CXCL1, G-CSF, and GM-CSF were increased in RSV-infected mice treated with AgNPs, consistent with an increase of neutrophil recruitment and activation in the lung tissue. Following experimental antibody-dependent depletion of neutrophils, the antiviral effect of AgNPs in mice treated was ablated. To our knowledge, this is the first in vivo report demonstrating antiviral activity of AgNPs during RSV infection.

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“…In addition, metal nanoparticles are a few hundred nanometers smaller than comparable large biological molecules such as enzymes, receptors and antibodies [1]. The unique physical and chemical properties of metal nanoparticles may lead to effective interactions between itself, bacterial cell membrane and other biological entities [1,10]. The antimicrobial activity of nanoparticles is not well understood, however, various mechanisms have been suggested.…”

Section: Introductionmentioning

confidence: 99%

Catalytic degradation of methylene blue by iron nanoparticles synthesized using Galinsoga parviflora, Conyza bonariensis and Bidens pilosa leaf extracts

et al. 2019

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Green synthesized metallic nanoparticles are environmentally friendly, bio-compatible, and highly stable. The aim of this study was to synthesize iron nanoparticles (FeNPs) from FeCl 3 solution using aqueous leaf extracts of Galinsoga parviflora (Gp), Conyza bonariensis (Cb) and Bidens pilosa (Bp) and use them in degradation of methylene blue dye. The iron nanoparticles were characterized using UV-Vis spectrophotometer, FT-IR spectrophotometer, X-ray Fluorescence (EDXRF), X-ray diffractometer (XRD), and scanning electron microscope (SEM). Phytochemical screening for presence of secondary metabolites revealed presence of phenolics, phytosterols and flavonoids. The total phenolic and flavonoid content in Galinsoga parviflora, Conyza bonariensis and Bidens pilosa leaf extracts were 57.67 ± 1.27, 117.13 ± 0.03, 126.27 ± 0.013 mg Gallic Equivalent/g of Dry Weight (mg GAE/g DW) and 39.00 ± 0.56, 45.50 ± 0.59, 33.13 ± 0.81 mg Rutin Equivalent/g of Dry Weight (mg RE/g DW) respectively. The UV-Vis spectrum of FeCl 3 had a shoulder at 320 nm, which disappeared upon addition of G. parviflora, C. bonariensis and B. pilosa extracts confirming formation of iron nanoparticles. Evaluation of iron content of the synthesized nanoparticles revealed that the iron content in G. parviflora, C. bonariensis and B. pilosa extracts was 51, 47 and 44% respectively. XRD data revealed presence of a large amorphous coating that masked iron peaks, though 2 theta values observed have been reported to be of iron oxides. Methylene blue degradation studies revealed that CbNPs, BpNPs and GpNPs synthesized were good biocatalysts as they degraded the dye by 86, 84.3 and 92% respectively. Therefore, green synthesized iron nanoparticles is cost effective and environmentally safe in providing insight in the environmental removal of dyes.

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Current Approaches for Exploration of Nanoparticles as Antibacterial Agents

Cited by 28 publications

References 141 publications

Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives

Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives

Antiviral and Immunomodulatory Activity of Silver Nanoparticles in Experimental RSV Infection

Catalytic degradation of methylene blue by iron nanoparticles synthesized using Galinsoga parviflora, Conyza bonariensis and Bidens pilosa leaf extracts

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