Current Aspects of Use of Nasal Vasoconstrictors and Adjunctive Agents in Pediatric Practice

Тулупов, Д. А.; Fedotov, F. A.; Карпова, Е. П.; Grabovskaya, V. A.

doi:10.21518/2079-701x-2018-2-114-117

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…Depression of the central nervous system (alteration of consciousness progressing to coma) occurred in case of an accidental ingestion of the drug (swallowing) or a one-time instillation of a large dose of naphazoline (Taylor and Maslov 2013;Lowry and Brown 2014). As reported by most studies, this effect is especially prominent in early childhood (Senin and Morozov 2012;Kalashnikova and Chelpachenko 2013;Taylor and Maslov 2013;Lowry and Brown 2014;Díaz et al 2018;Pshenichnaya et al 2018;Petukhova et al 2019;Shilov et al 2019;Tulupov et al 2018;Euwema and Swanson 2020).…”

Section: Epidemiologymentioning

confidence: 96%

“…According to some data, the share of poisonings by this group of drugs ranged from 4% to 25.9% during the period from 2000 to 2018 (Petukhova et al 2019;Shilov et al 2019;Zhamlikhanov and Fedorov 2019). Most often the poisoning occurred when drugs with naphazoline as the main active ingredient were used (up to 86.8% of all the poisonings by drugs of this group) (Tulupov et al 2018;Petukhova et al 2019;Shilov et al 2019). According to the foreign studies in several countries, such as Croatia, Belgium and France, cases of acute poisoning by naphazoline were noted both after its normal therapeutic usage and due to overdose (Taylor and Maslov 2013;Lowry and Brown 2014;Díaz et al 2018;Euwema and Swanson 2020).…”

Section: Epidemiologymentioning

confidence: 99%

“…The cavernous tissue in the inferior and middle nasal turbinates only starts to develop in infants and is finally formed by the age of three. Therefore, nasal edema and inflammation in infants are mainly due to the filling of superficial arterioles with blood (Tulupov et al 2018). For this reason, alpha2-adrenergic agonists cannot act upon alpha2-adrenergic receptors, instead the alpha 1 -adrenergic receptors are stimulated.…”

Section: Anatomical and Physiological Specific Features Of The Nose Structure In Childrenmentioning

confidence: 99%

“…Naphazoline causes systemic side effects (toxicity) primarily in children. Drug overdose of just a few extra drops can lead to severe intoxication (Tulupov et al 2018). Clinical manifestations of the adrenomimetic effect (neurological status impairment, changes in the cardiovascular system, hypothermia, excessive constriction of the pupils) may occur even as a result of a therapeutic use of the drug (Claudet and Fries 1997;Varvyanskaya and Lopatin 2015).…”

Section: Main Causes Of Acute Poisoning In Young Childrenmentioning

confidence: 99%

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Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

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Introduction: Acute poisoning by nasal decongestants is an important issue in pediatrics due to physiological and anatomical characteristics of the child’s body and pharmacokinetics of drugs in early childhood. Epidemiology: The number of poisonings by this group of drugs ranged from 4% to 39% during the period from 2000 to 2018. All the studies reported that the most severe degree of intoxication was observed in children aged 1–3 years. Mechanism of action of nasal decongestants: The peculiarity of selective alpha2-adrenergic agonists is that when taken orally, misused or overdosed, they lose their selectivity for the target receptor. As a result, the drug causes acute poisoning and most often this effect occurs in children and adolescents. Clinical features and diagnostic criteria: Clinical signs of acute poisoning can appear both as a result of an overdose of the nasal decongestants and due to a therapeutic use of the drug according to the instruction. The symptoms are manifested by hypothermia, skin pallor, bradycardia, arterial hypotension, profuse sweating, and acrocyanosis. Imidazoline receptors and new opportunities: It is assumed that toxic effect of topical decongestants occurs not only by activation of alpha2-adrenergic receptors, but also through their influence on the selective imidazoline receptors. Based on the structure of these drugs, it is assumed that imidazoline receptors are the primary binding site for these drugs. Conclusion: Understanding the described mechanisms of alpha2-adrenergic agonist action and peculiarities of the child’s symptoms in acute poisoning is necessary for the timely diagnosis and selection of the correct treatment strategy.

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Section: Epidemiologymentioning

confidence: 96%

Section: Epidemiologymentioning

confidence: 99%

Section: Anatomical and Physiological Specific Features Of The Nose Structure In Childrenmentioning

confidence: 99%

Section: Main Causes Of Acute Poisoning In Young Childrenmentioning

confidence: 99%

See 2 more Smart Citations

Pathogenetic features of acute naphazoline poisoning in children

Karpushkina¹,

Zhdanova²,

Батищева³

et al. 2021

RRP

View full text Add to dashboard Cite

show abstract

The frequency of adverse events associated with the use of nasal decongestants in children during the COVID-19 pandemic (2019—2020)

Карпова¹,

Тулупов²,

Gulieva³

et al. 2022

Ross. rinol.

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The efficacy of silver proteinate in the treatment of acute nasopharyngitis

et al. 2020

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Acute nasopharyngitis is the most common reason for visit a doctor, usually benign, self-limited disease. It is also characterized by a high frequency of complications in children and nonspecific symptoms that require special care from the doctor when examining patients. The clinical and social significance of acute nasopharyngitis is due to their high prevalence, and inadequate treatment leads to a protracted course or to a transition to a chronic one. The relevance of this problem adds to the presence of a large number of various drugs, but not many drugs have evidence-based effectiveness. In the treatment of acute nasopharyngitis local drugs are very important. The drug is a silver proteinate agent with broad antibacterial anti-inflammatory activity. The drug is used to treat infectious rhinitis. This article evaluates the use of a new form of the silver proteinatedrug, the drug is available in the pharmacy, easy to use, long shelf life. This article describes the place of silver proteinate among drugs that help to relieve the symptoms of acute nasopharyngitis and provides data on its effectiveness, safety and features of use in children. The drug can take a worthy place among topical drugs due to its high efficiency in the treatment of acute rhinitis and its possible use at any age.

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Current Aspects of Use of Nasal Vasoconstrictors and Adjunctive Agents in Pediatric Practice

Cited by 8 publications

References 9 publications

Pathogenetic features of acute naphazoline poisoning in children

Pathogenetic features of acute naphazoline poisoning in children

The frequency of adverse events associated with the use of nasal decongestants in children during the COVID-19 pandemic (2019—2020)

The efficacy of silver proteinate in the treatment of acute nasopharyngitis

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