Current Concept Review: State of Acute Lateral Ankle Injury Classification Systems

Lacerda, Diogo; Pacheco, Dúnio; Rocha, Ana Luiza Lunardi; Diniz, Pedro; Pedro, Inês; Pinto, Francisco

doi:10.1053/j.jfas.2022.08.005

Cited by 5 publications

(2 citation statements)

References 65 publications

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“…The availability of research data from high-quality trials seeking to optimize the management of acute ankle sprains remains limited and sometimes conflicting, as many widely used treatments lack EBM level 1 evidence [6]. Guidelines do exist but are often based on observation and opinion [4,44]. This three-arm, placebo-controlled randomized trial sought to generate high-quality evidence data by examining the effects of two widely used topical gels for Grades 1 and 2 ankle sprain injuries in adults, according to current guidelines for Good Clinical Practice.…”

Section: Discussionmentioning

confidence: 99%

Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial

Gerdesmeyer,

Vester,

Schneider

et al. 2024

JCM

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Background: Topical NSAIDs are widely used to treat ankle sprains. Traumed (Tr14) gel is a multicomponent formulation, demonstrating inflammation-resolution properties. Methods: This multicenter, double-blind trial investigated the efficacy and safety of Tr14 gel versus placebo gel and non-inferiority versus 1% diclofenac gel, applied 3×/day for 7 days after acute lateral ankle sprain (EudraCT Number: 2016-004792-50). The primary outcome was AUC for pain on passive movement, assessed by VAS from baseline to Days 4 and 7. Results: The trial population included 625 patients aged 18 to 78 years. The AUC scores were 187.88 and 200.75 on Day 4 (p = 0.02) and 294.14 and 353.42 on Day 7 (p < 0.001) for Tr14 and placebo, respectively. For Tr14 compared to diclofenac, the AUC scores were 187.50 and 197.19 on Day 4 (p = 0.3804) and 293.85 and 327.93 on Day 7 (p = 0.0017), respectively. On the FAAM-ADL subscale, Tr14 was superior to placebo and non-inferior to diclofenac at all time points. Time to 50% pain improvement was lowest for Tr14 (6.0 days), compared to placebo (7.1 days) and diclofenac (7.0 days). Adverse events were uncommon and minor. Conclusions: Tr14 gel is effective and safe in acute ankle sprains, compared to placebo gel and diclofenac gel, and has faster pain resolution. Trial registration: The trial was registered in clinicaltrialsregister.eu, EudraCT number 2016-004792-50 on 07.06.2017.

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Section: Discussionmentioning

confidence: 99%

Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial

Gerdesmeyer,

Vester,

Schneider

et al. 2024

JCM

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“…For instance, there are three ligaments that are implicated in a lateral ankle sprain. Some categorizations use 3rd degree ankle sprain to refer to the complete tearing of each ligament, while some consider a 3rd degree ankle sprain to mean all three ligaments are damaged (Wolfe et al 2001 ; Lacerda et al 2023 ). Surgery may be recommended for some complete ligament tears but not others (Beynnon et al 2005 ; Miyamoto et al 2009 ; Stone et al 2021 ).…”

Section: Main Textmentioning

confidence: 99%

Principles of musculoskeletal sport injuries for epidemiologists: a review

Wang,

Stovitz,

Kaufman

et al. 2024

Inj. Epidemiol.

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Background Musculoskeletal injuries are a common occurrence in sport. The goal of sport injury epidemiology is to study these injuries at a population level to inform their prevention and treatment. Main body This review provides an overview of musculoskeletal sport injuries and the musculoskeletal system from a biological and epidemiologic perspective, including injury mechanism, categorizations and types of sport injuries, healing, and subsequent injuries. It is meant to provide a concise introductory substantive background of musculoskeletal sport injuries for epidemiologists who may not have formal training in the underlying anatomy and pathophysiology. Conclusion An understanding of sport injuries is important for researchers in sport injury epidemiology when determining how to best define and assess their research questions and measures.

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Rehabilitation and Gamification Technology Device for Lower Extremities Patient: A Review

Ismail,

Adib

2024

Lecture Notes in Mechanical Engineering

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Current Concept Review: State of Acute Lateral Ankle Injury Classification Systems

Cited by 5 publications

References 65 publications

Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial

Topical Treatment Is Effective and Safe for Acute Ankle Sprains: The Multi-Center Double-Blind Randomized Placebo-Controlled TRAUMED Trial

Principles of musculoskeletal sport injuries for epidemiologists: a review

Rehabilitation and Gamification Technology Device for Lower Extremities Patient: A Review

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