Current Concepts

The prevalence of acromegaly in hospitalized patients with type 2 diabetes

“…Although case 4 showed random GH levels of >1ng/mL, in case 3, random GH levels were <1ng/mL. While impaired GH suppression can occur in conditions including chronic renal insufficiency, liver failure, hyperthyroidism, anorexia nervosa, malnutrition and adolescence [22], there are patients of active acromegaly with clearly elevated IGF-1 concentrations with apparently 'normal' plasma GH concentrations [23], suggesting that GH concentrations vary depending on conditions. Taken together, it might be useful to screen for acromegaly by measuring serum GH levels in patients with T2DM, but it requires further investigation.…”

“…Taken together, it might be useful to screen for acromegaly by measuring serum GH levels in patients with T2DM, but it requires further investigation. IGF-1 levels can be elevated in some adolescents, patients with hyperthyroidism, and pregnant women but are rarely elevated in conditions other than acromegaly [22]. We excluded these conditions in this study; finally, 20 out of 317 patients (6.3%) showed elevated serum IGF-1 levels.…”

Prevention of Rh-haemolytic disease: results of the clinical trial. A combined study from centres in England and Baltimore.

“…The basis of the procedure was to remove rapidly from the circulation previously injected chromium-tagged Rhpositive red cells by giving high-titre anti-D as an infusion of plasma. Later Gorman et al (1963) (see also Freda and Gorman, 1962;Freda et al, 1964) suggested the use of anti-D gamma-globulin instead of plasma, and since then we have used gamma-globulin. In our third paper we showed that injected Rh-positive foetal cells could be cleared from the circulation of Rh-negative women volunteers as effectively as the Rh-positive adult cells were cleared from the Rh-negative men.…”