Current Concepts in Therapy

Hd, Riley

doi:10.1097/00007611-197302000-00022

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1987

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“…1, 2). The breakpoints for rifampin MICs were based on pharmaco kinetic results published by other authors [2,8,12,24], and assuming residual plasma concentrations of 2 ¡ig/m\ at 12 h following oral administration of 600 mg of rifampin. The proposed inhibition zone criteria for 2 ug rifampin disks against sta phylococci revealed 2 minor discrepancies for S. aureus and 3 minor discrepancies for CONS isolates, respectively, and, more important, no major or very major discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Tentative Inhibition Zone Criteria (Bauer-Kirby Agar Disk Diffusion Method) for Rifampin against Staphylococci

Traub

Spohr

Bauer³

1987

Chemotherapy

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Two of 359 (0.6%) clinical isolates of Staphylococcus aureus and 12 of 218 (5.5%) clinical isolates of coagulase-negative staphylococci were resistant or of intermediate susceptibility against rifampin as based on minimal inhibitory concentration (MIC) breakpoints obtained with the agar dilution method: MIC ≥2 μg/ml = resistant; MIC 0.25–1 μg/ml = intermediate susceptible; MIC ≤0.125 μg/ml= susceptible. The following inhibition zone criteria with 2 μg rifampin disks were proposed for staphylococcal isolates utilizing the Bauer-Kirby agar disk diffusion test: diameter of inhibition zones ≤13 mm = resistant; diameter 14–21 mm = intermediate susceptible; diameter ≥22 mm = susceptible.

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Section: Discussionmentioning

confidence: 99%