Current concepts in vitamin D and orthopaedic surgery

Moon, Andrew S.; Boudreau, Sellers; Mussell, Eric; He, Jun Kit; Brabston, Eugene W.; Ponce, Brent A.; Momaya, Amit

doi:10.1016/j.otsr.2018.12.006

Cited by 26 publications

(22 citation statements)

References 70 publications

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“…4) Vitamin D plays an important role in the musculoskeletal system, as it affects the regulation of bone health, fracture healing, and soft-tissue healing and function. 5) Recent studies have shown that low levels of vitamin D have negative effects on articular cartilage. [5][6][7][8] Several studies have reported that sufficient vitamin D supplementation can increase upper and lower body muscle strength.…”

mentioning

confidence: 99%

Prevalence of and Risk Factors for Hypovitaminosis D in Patients with Rotator Cuff Tears

Lee

Kim

et al. 2021

Clin Orthop Surg

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Vitamin D deficiency is known to affect more than 1 billion people worldwide. 1) In the USA, its prevalence has been reported to be 40%. 2) Recently, vitamin D deficiency in Asian countries has been the focus of attention because it has been reported to have a prevalence of up to 70%. Vitamin D deficiency in Asian countries seems to be more serious than that in western countries. 3,4) Based on the Korea National Health and Nutrition Examination Survey (KNHANES), there has been a gradual increase in the prevalence of vitamin D deficiency in the Korean population over time. 4) Vitamin D plays an important role in the musculoskeletal system, as it affects the regulation of bone health, fracture healing, and soft-tissue healing and function. 5) Recent studies have shown that low levels of vitamin D have negative effects on articular cartilage. [5][6][7][8] Several studies have reported that sufficient vitamin D supplementation can increase upper and lower body muscle strength. 9) In particular, in the elderly, vitamin D supplementation has been shown to reduce the risks of fragile fractures and falls. 10) The pathophysiologic role of vitamin D in the rota-

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confidence: 99%

Prevalence of and Risk Factors for Hypovitaminosis D in Patients with Rotator Cuff Tears

Lee

Kim

et al. 2021

Clin Orthop Surg

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“…Vitamin D plays an important role in orthopedic surgery [ 92 ]. Low vitamin D levels in patients undergoing total hip replacement have been associated with lower pre- and postoperative Harris hip score [ 93 ], increase of postoperative complications, including periprosthetic joint infection [ 72 ] as well as longer hospital stays [ 74 ].…”

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confidence: 99%

How can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?

et al. 2021

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In this narrative review, the role of vitamin D deficiency in the pathophysiology, healing of fragility fractures, and rehabilitation is discussed. Vitamin D status can be assessed by measuring serum 25(OH)-vitamin D level with standardized assays. There is a high prevalence of vitamin D insufficiency (25(OH)D < 50 nmol/l (i.e., 20 ng/mL)) or deficiency (25(OH)D < 25 nmol/l (i.e., 10 ng/mL)) in patients with fragility fractures and especially in those with a hip fracture. The evidence on the effects of vitamin D deficiency and/or vitamin D supplementation on fracture healing and material osseointegration is still limited. However, it appears that vitamin D have a rather positive influence on these processes. The fracture liaison service (FLS) model can help to inform orthopedic surgeons, all caregivers, and fractured patients about the importance of optimal vitamin D status in the management of patients with fragility fractures. Therefore, vitamin D status should be included in Capture the Fracture® program as an outcome of FLS in addition to dual-energy X-ray absorptiometry (DXA) and specific antiosteoporosis medication. Vitamin D plays a significant role in the pathophysiology and healing of fragility fractures and in rehabilitation after fracture. Correction of vitamin D deficiency should be one of the main outcomes in fracture liaison services.

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“…These include patients scheduled for foot and ankle, spine, knee, shoulder and elbow surgery as well as arthroplasty including hip, knee and shoulder arthroplasty (12,24,75,77,78). Several orthopaedic diseases have also been associated with low vitamin D levels (79). For example, it has been demonstrated that patients with decreased articular cartilage thickness were more likely to be vitamin D insufficient and, thus, low vitamin D status might be a risk factor for the development of osteoarthritis (3).…”

Section: Vitamin D In Orthopaedicsmentioning

confidence: 99%

“…In addition, the outcome of vitamin D deficient orthopaedic patients has been reported to be worse in a variety of orthopaedic surgeries (79). Notably, low vitamin D levels in orthopaedic patients have also been associated with an increased length of hospital stay (87).…”

Section: Vitamin D In Orthopaedicsmentioning

confidence: 99%

“…Clinically, accelerated bone turnover-as seen in patients with severe vitamin D deficiency-is associated with higher rates of skeletal related events and poorer prognosis in patients with different cancers (79)(80)(81). Furthermore, there is increasing evidence that low vitamin D levels are associated with advanced tumour stage in patients with multiple myeloma (124).…”

Section: Vitamin D In Bone Oncologymentioning

confidence: 99%

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The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature

Maier¹,

Weißenberger

Rudert

et al. 2021

Ann Transl Med

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Vitamin D is considered to play an important role in musculoskeletal health. It's classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.

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Current concepts in vitamin D and orthopaedic surgery

Cited by 26 publications

References 70 publications

Prevalence of and Risk Factors for Hypovitaminosis D in Patients with Rotator Cuff Tears

Prevalence of and Risk Factors for Hypovitaminosis D in Patients with Rotator Cuff Tears

How can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?

The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature

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