“…Mastocytosis is suspected as rare underlying cause of idiopathic urticaria or bee sting anaphylaxis , but association with angioedema and orbital involvement is rare. There has been no report of facial nerve palsy associated with mastocytosis . The most common symptom in childhood CM (90% of patients), which is usually manifested by 2 years of age , is skin lesions, which turn to reddening, urticarial swelling, and pruritus, caused by mediators released from mast cell activation triggered by temperature change, skin friction, ingestion of hot beverage, spicy foods, or certain drugs .…”