Current Developments in Antimicrobial Surface Coatings for Biomedical Applications

Swartjes, Jan J. T. M.; Sharma, Prashant K.; Kooten, van Theo; Mei, van der Henny C.; Mahmoudi, Morteza; Busscher, Henk J.; Rochford, Edward T.J.

doi:10.2174/0929867321666140916121355

Cited by 132 publications

(112 citation statements)

References 128 publications

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“…Advances in material and surface engineering have led to the development of well-defined topographic surface patterns that can control biofilm formation without including antimicrobial agents 112 . The most well-established ordered topography is the Sharklet™ surface.…”

Section: The Promise Of New Technologiesmentioning

confidence: 99%

Targeting microbial biofilms: current and prospective therapeutic strategies

et al. 2017

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Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections. The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobials, and indicates the need for multi-targeted or combinatorial therapies. In this review, we focus on current therapeutic strategies and those that are under development that target vital structural and functional traits of microbial biofilms and drug tolerance mechanisms, including the extracellular matrix and dormant cells. We emphasize strategies that are supported by in vivo or ex vivo studies, highlight emerging biofilm-targeting technologies, and provide a rationale for multi-targeted therapies that are aimed at disrupting the complex biofilm microenvironment.

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Section: The Promise Of New Technologiesmentioning

confidence: 99%

Targeting microbial biofilms: current and prospective therapeutic strategies

et al. 2017

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“…Hydrophobic and superhydrophobic surface treatment technologies have also shown a great repellent antibacterial effect in preclinical studies 23 - 25.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid and Its Composites as a Local Antimicrobial/Antiadhesive Barrier

Romanò¹,

Vecchi

Bortolin

et al. 2017

J. Bone Joint Infect.

121

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Living in biofilms is probably the most common condition for bacteria and fungi and biofilm-related infections account for the majority of bacterial infectious diseases worldwide.Among others biofilm-related infections, those associated with implanted biomaterials have an enormous and still largely underestimated impact in orthopaedics and trauma, cardio-surgery and several other surgical disciplines.Given the limited efficacy of existing antibiotics in the prevention and treatment of bacterial biofilms, new strategies are needed to protect implants and host tissues, overcoming the striking ability of the microorganisms to adhere on different surfaces and to immediately protect themselves by forming the biofilm matrix.Adhesion is a necessary first step in microbial colonization and pathogenesis and provides a potential target for new preventive and treatment approach.Among various polymers, tested as antibacterial coatings, hyaluronic acid and some of its composites do offer a well-established long-term safety profile and a proven ability to reduce bacterial adhesion and biofilm formation.Aim of the present review is to summarize the available evidence concerning the antiadhesion/antibiofilm activity of hyaluronic acid and some of its derivatives to reduce/prevent bacterial adhesion and biofilm formation in various experimental and clinical settings.

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“…Thus, numerous strategies to prevent biofilm formation have been reported in the past two decades [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. One prominent strategy is to coat materials with polycationic surfaces which then kill bacteria upon contact due to their interaction with the bacteria's negatively charged cell membranes [9,20,21].…”

Section: Introductionmentioning

confidence: 99%

Surface-Attached Poly(oxanorbornene) Hydrogels with Antimicrobial and Protein-Repellent Moieties: The Quest for Simultaneous Dual Activity

Kurowska¹,

Widyaya²,

Al‐Ahmad³

et al. 2018

Materials

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By copolymerizing an amphiphilic oxanorbornene monomer bearing N- tert-butyloxycarbonyl (Boc) protected cationic groups with an oxanorbornene-functionalized poly(ethylene glycol) (PEG) macromonomer, bifunctional comb copolymers were obtained. Varying the comonomer ratios led to copolymers with PEG contents between 5–25 mol %. These polymers were simultaneously surface-immobilized on benzophenone-bearing substrates and cross-linked with pentaerythritoltetrakis(3-mercaptopropionate). They were then immersed into HCl to remove the Boc groups. The thus obtained surface-attached polymer hydrogels (called SMAMP*-co-PEG) were simultaneously antimicrobial and protein-repellent. Physical characterization data showed that the substrates used were homogeneously covered with the SMAMP*-co-PEG polymer, and that the PEG moieties tended to segregate to the polymer–air interface. Thus, with increasing PEG content, the interface became increasingly hydrophilic and protein-repellent, as demonstrated by a protein adhesion assay. With 25 mol % PEG, near-quantitative protein-adhesion was observed. The antimicrobial activity of the SMAMP*-co-PEG polymers originates from the electrostatic interaction of the cationic groups with the negatively charged cell envelope of the bacteria. However, the SMAMP*-co-PEG surfaces were only fully active against E. coli, while their activity against S. aureus was already compromised by as little as 5 mol % (18.8 mass %) PEG. The long PEG chains seem to prevent the close interaction of bacteria with the surface, and also might reduce the surface charge density.

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Current Developments in Antimicrobial Surface Coatings for Biomedical Applications

Cited by 132 publications

References 128 publications

Targeting microbial biofilms: current and prospective therapeutic strategies

Targeting microbial biofilms: current and prospective therapeutic strategies

Hyaluronic Acid and Its Composites as a Local Antimicrobial/Antiadhesive Barrier

Surface-Attached Poly(oxanorbornene) Hydrogels with Antimicrobial and Protein-Repellent Moieties: The Quest for Simultaneous Dual Activity

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