Current developments in cell- and biomaterial-based approaches for stroke repair

Jendelová, Pavla; Kubinová, Šárka; Sandvig, Ioanna; Erceg, Slaven; Sandvig, Axel; Syková, Eva

doi:10.1517/14712598.2016.1094457

Cited by 29 publications

(26 citation statements)

References 113 publications

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“…Cross-callosal, transhemispheric migration has previously been reported, especially for bone-marrow stromal cells. However, in those cases the stem cells were originally transplanted in the contralesional hemisphere after stroke induced injury [6,43]. Furthermore, after ischemic lesion, intracortically transplanted NSCs have been shown to migrate away from the initial graft location and to align themselves with the corpus callosum [44].…”

Section: Discussionmentioning

confidence: 99%

“…Notwithstanding that the variability of lesion pathology between subjects in a given cohort post-MCAo may confound a thorough elucidation of the exact mechanisms involved, it is worth considering how future strategies for stroke repair may involve OECs as part of an in situ tissue engineering paradigm as an alternative to or in combination with other approaches, as for example tailored biomaterials [6,7,53,55].…”

Section: Discussionmentioning

confidence: 99%

“…Such approaches, which incorporate state-of-the-art advances in the field [56] are highly promising with a view to preserving and/or restoring host tissue as well as optimizing implant-derived effects that enhance brain plasticity for functional restoration [6,56].…”

Section: Discussionmentioning

confidence: 99%

“…Cell replacement therapy in the sub-acute or chronic stage offers the option of extending the narrow therapeutic window while addressing a key constituent of stroke pathophysiology, namely the cell loss caused by ischemia. In this context, a number of studies have demonstrated the potential of stem cell treatment in promoting tissue remodeling in animal models of ischemic stroke injury [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat

et al. 2017

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Effects of neural stem cell and olfactory ensheathing cell cotransplants on tissue remodelling after transient focal cerebral ischemia in the adult rat. Neurochemical Research, 42(6), pp. 1599-1609.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/136264/ with the host-tissue post-transplantation is poor. In this study, we address this challenge by testing whether co-grafting of NSCs with olfactory ensheathing cells (OECs), a special type of glia with proven neuroprotective, immunomodulatory, and angiogenic effects, can promote graft survival and host tissue remodelling. Transient focal cerebral ischemia was induced in adult rats by a sixty-minute middle cerebral artery occlusion (MCAo) followed by reperfusion. Ischemic lesions were verified by neurological testing and magnetic resonance imaging (MRI). Transplantation into the globus pallidus of NSCs alone or in combination with OECs was performed at two weeks post-MCAo, followed by histological analyses at three weeks post-transplantation. We found evidence of extensive vascular remodelling in the ischemic core as well as evidence of NSC motility away from the graft and into the infarct border in severely lesioned animals co-grafted with OECs. These findings support a possible role of OECs as part of an in situ tissue engineering paradigm for transplant mediated repair of ischemic brain lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat

et al. 2017

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“…On injection, the fluid flows to fill extracellular spaces in the brain, filling irregular voids (where required) and interfacing fully with surrounding tissue, then promptly self‐assembling within minutes into a stiffer gel that can be tailored to match the mechnical properties of the brain, and support surrounding host, or newly implanted cells. Such materials [including hyaluronic acid (HA) and collagen gels] have been shown to support both fetal and human PSC‐derived progenitors in vitro and cell engraftment in PD and stroke models (Jin et al ., ; Yu et al ., ; Zhong et al ., ; Adil et al ., ; Moriarty et al ., ; see also reviews – Jendelova et al ., ; Moriarty and Dowd, ; Moriarty et al ., ).…”

Section: Biomaterials As Tissue Engineering Scaffoldsmentioning

confidence: 99%

Harnessing stem cells and biomaterials to promote neural repair

Bruggeman

Moriarty

Dowd

et al. 2018

British J Pharmacology

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With the limited capacity for self‐repair in the adult CNS, efforts to stimulate quiescent stem cell populations within discrete brain regions, as well as harness the potential of stem cell transplants, offer significant hope for neural repair. These new cells are capable of providing trophic cues to support residual host populations and/or replace those cells lost to the primary insult. However, issues with low‐level adult neurogenesis, cell survival, directed differentiation and inadequate reinnervation of host tissue have impeded the full potential of these therapeutic approaches and their clinical advancement. Biomaterials offer novel approaches to stimulate endogenous neurogenesis, as well as for the delivery and support of neural progenitor transplants, providing a tissue‐appropriate physical and trophic milieu for the newly integrating cells. In this review, we will discuss the various approaches by which bioengineered scaffolds may improve stem cell‐based therapies for repair of the CNS.

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MRI‐Visible siRNA Nanomedicine Directing Neuronal Differentiation of Neural Stem Cells in Stroke

Wang

Zhang

et al. 2018

Adv Funct Materials

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A major challenge in stroke treatment is the restoration of neural circuit in which neuron function plays a central role. Although transplantation of exogenous neural stem cells (NSCs) is admittedly a promising therapeutical means, the treatment outcome is greatly affected due to the poor NSCs differentiation into neurons caused by myelin associated inhibitory factors binding to Nogo-66 receptor (NgR). Herein, a nanoscale polymersome is developed to codeliver superparamagnetic iron oxide nanoparticles and siRNA targeting NgR gene (siNgR) into NSCs. This multifunctional nanomedicine directs neuronal differentiation of NSCs through silencing the NgR gene and meanwhile allows a noninvasive monitoring of NSC migration with magnetic resonance imaging. An improved recovery of neural function is achieved in rat ischemic stroke model. The results demonstrate the great potential of the multifunctional siRNA nanomedicine in stroke treatment based on stem cell transplantation.

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Current developments in cell- and biomaterial-based approaches for stroke repair

Cited by 29 publications

References 113 publications

Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat

Effects of Neural Stem Cell and Olfactory Ensheathing Cell Co-transplants on Tissue Remodelling After Transient Focal Cerebral Ischemia in the Adult Rat

Harnessing stem cells and biomaterials to promote neural repair

MRI‐Visible siRNA Nanomedicine Directing Neuronal Differentiation of Neural Stem Cells in Stroke

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