Current diagnostic methods for HIV

Tavakoli, Ahmad; Niya, Mohammad Hadi Karbalaie; Keshavarz, Mohsen; Ghaffari, Hadi; Asoodeh, Amir; Monavari, Seyed Hamidreza; Keyvani, Hossein

doi:10.2217/fvl-2016-9999

Cited by 5 publications

(5 citation statements)

References 97 publications

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“…34 Selective detection schemes require sensor molecules, such as antibodies, 35,36 enzymes, 37,38 or aptamers, 39,40 that are specific for binding and detecting one analyte. Such systems have strong commercial successes in pregnancy tests, 41,42 HIV diagnostic systems, 43,44 and glucose monitoring equipment, 45,46 all of which require specificity for one analyte. However, since most analytes share similar structural features with a large range of other molecules, identifying a sensor that binds only a single target analyte is often impractical, and sensitive detection can be the most feasible option.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Luminescent Sensors

2018

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There is great need for stand-alone luminescence-based chemosensors that exemplify selectivity, sensitivity, and applicability and that overcome the challenges that arise from complex, real-world media. Discussed herein are recent developments toward these goals in the field of supramolecular luminescent chemosensors, including macrocycles, polymers, and nanomaterials. Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores. State-of-the-art developments in the fields of polymer and nanomaterial sensors are also examined, and some remaining unsolved challenges in the area of chemosensors are discussed. CONTENTS 4.4. Explosives 4.5. Pharmaceutical Agents 4.6. Biologically Relevant 4.6.1. Adenosine Triphosphate (ATP)

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Section: Introductionmentioning

confidence: 99%

Supramolecular Luminescent Sensors

2018

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“…B19V infection and the consequent anemia are considered serious issues in HIV patients. A proportion of patients are cured by blood transfusions and high-dose intravenous immunoglobulin (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Association between Parvovirus B19 and anemia in HIV-infected patients

Nouri

Kamakifar

Khodabandehlou

et al. 2019

Med. J. Islam. Republ. Iran

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Parvovirus B19 infection is involved in several clinical manifestations such as erythema infectiosum, chronic arthritis, hydrops fetalis, and transient aplastic crisis in patients with sickle cell anemia and pure red cell aplasia in immunocompromised hosts. This virus can lead to self-limited anemia in healthy individuals; however, it can develop into chronic anemia in immunocompromised cases. →What this article adds: The present study evaluated the association between anemia and B19V in HIV patients. Also, the threat of B19V is limited in the HIV patients receiving ART, whereas persistent B19 viremia in the untreated patients may lead to anemia.

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“…Interestingly, besides reducing HIV transmission through intravenous drug abuse, sexual transmission had been increasing (36.8%) . Since infection with HCV through sexual transmission is an infrequent event, it seemed the number of HIV/HCV co‐infection will be reduced in Iran in the future . In this study, 55 (39.3%) of the HIV‐infected patients had a history of unprotected sex and were presumably infected with HIV through sexual intercourse.…”

Section: Discussionmentioning

confidence: 79%

Presence of different hepatitis C virus genotypes in plasma and peripheral blood mononuclear cell samples of Iranian patients with HIV infection

Dehghani‐Dehej

Sarvari

Esghaei

et al. 2018

Journal of Medical Virology

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Due to the similar routes of transmission, individuals infected with the human immunodeficiency virus (HIV) may become infected with the hepatitis C virus (HCV) simultaneously. The aim of this study was to investigate the frequency of HCV co-infection in Iranian individuals with HIV infection, and to genotype HCV in plasma and PBMC specimens of these patients. From September 2015 to October 2016, a total of 140 Iranian individuals with HIV infection were enrolled in this cross-sectional study. The RNA from plasma and PBMC specimens was extracted, and genomic HCV-RNA was amplified using RT-nested PCR with primers that target 5'-UTR. The HCV genotyping used the RFLP technique. To confirm HCV genotype, 10 randomly selected HCV-positive samples were also submitted for sequencing. The mean age of patients was 35.7 ± 13.5 years (range: 1-66). Out of 140 patients, 62 (44.3 %) were positive for anti-HCV antibodies; among these, viral genomic RNA was detected in 34 (24.3%) and 39 (27.9%) of the plasma and PBMC specimens, respectively. The HCV genotyping showed a similar pattern of subtypes 1a (44% vs 46.2%), 3a (32.4% vs 33.3%), and 1b (17.6% vs 17.9%) in all sera and PBMC samples. It is noteworthy that the HCV genotypes in plasma and PBMC specimens of 6 HCV co-infected patients were not the same. This study reveals that HIV/HCV co-infection is high in Iranian patients (44.3%), especially in people who have high-risk factors (83.9%). Also, HIV/HCV co-infected individuals may have dissimilar HCV genotypes in their plasma and PBMC specimens.

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Current diagnostic methods for HIV

Cited by 5 publications

References 97 publications

Supramolecular Luminescent Sensors

Supramolecular Luminescent Sensors

Association between Parvovirus B19 and anemia in HIV-infected patients

Presence of different hepatitis C virus genotypes in plasma and peripheral blood mononuclear cell samples of Iranian patients with HIV infection

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