Current Ideas About the Pathogenetic Mechanisms of Pain in Osteoarthrosis

Туровская, Екатерина Федоровна; Алексеева, Л. И.; Filatova, E G

doi:10.14412/1995-4484-2014-438-444

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Ангиогенез -это рост кровеносных сосудов от существующей сосудистой системы, который необходим для роста и развития и восстановления тканей [15]. Результатом неоваскуляризации является приток медиаторов воспаления и, как следствие, усиление болевого синдрома в периартикулярных тканях и внутрисуставных структурных элементах -сухожилиях, энтезисах, суставной капсуле, хряще и т. д. Сопровождающий воспалительные изменения ангиогенез стимулирует прорастание новых сенсорных волокон в ткани поврежденного сустава и может способствовать хронизации боли даже после стихания воспаления [16]. Поскольку ангиогенез сопровождается ростом чувствительных нервов, периваскулярный нерв переходит обычно в аневральные структуры.…”

Section: клинический случай ¹unclassified

Successful experience of transcatheter arterial embolization for gonarthrosis in patients with severe pain syndrome and ineffectiveness of conservative therapy

Sharafutdinov

Рыжкин

Gaziev

et al. 2021

Regional blood circulation and microcirculation

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Osteoarthritis is a common disease of the musculoskeletal system, the cause of pain, loss of joint function and, as a consequence, a factor in the disability of the population. The treatment strategy for patients with gonarthrosis is not fully defined, especially in patients with stage 1–2. One of the treatment options for such patients is transcatheter embolization of the hypervascular network of the popliteal arteries. The article presents a series of clinical cases of embolization of the popliteal artery branches. Retrograde percutaneous puncture and catheterization of the target femoral artery were performed under local anesthesia. Then, selective angiography of the popliteal artery was performed to identify the hypervascular vasculature of the knee joint. After revealing the target artery along the interventional guidewire, selective catheterization of the artery of the hypervascular vascular network was performed using a microcatheter. Transcatheter arterial embolization of the hypervascular vascular network in osteoarthritis of various origins and localization can be successfully applied as an alternative treatment if conservative therapy is ineffective and if there are contraindications to surgical treatment. It should be noted that further randomized multicenter studies and meta-analyzes are needed to introduce this treatment method into everyday clinical practice.

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Section: клинический случай ¹unclassified

Successful experience of transcatheter arterial embolization for gonarthrosis in patients with severe pain syndrome and ineffectiveness of conservative therapy

Sharafutdinov

Рыжкин

Gaziev

et al. 2021

Regional blood circulation and microcirculation

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“…The pain that patients with osteoarthritis usually experience is based on two mechanisms: nociceptive (performing a protective function and arising from tissue damage and/or inflammation, due to activation of nociceptors of peripheral or deep tissues) and dysfunctional (not accompanied by neurological deficits or tissue disorders, and arising with various neuro-biological changes in the central nervous system) [5,6]. Therefore, pain might be one of signs that pathological processes occur in the synovial joints: destruction of articular cartilage, structural changes in the subchondral bone, inflammatory processes in synovium, tissue repair, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, pain might be one of signs that pathological processes occur in the synovial joints: destruction of articular cartilage, structural changes in the subchondral bone, inflammatory processes in synovium, tissue repair, etc. However, the manifestation of pain and dysfunction do not always correlate with the severity of pathological changes in the synovial joints area [5]. Taking this fact into account, it is assumed that, in addition to the severity of the pathological process in synovial joints, other factors are involved in the formation of pain, such as age, gender, race, duration of the disease, body mass index, state of mental health, etc.…”

Section: Introductionmentioning

confidence: 99%

Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

2021

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Synovial joints are unique biological tribosystems that allow a person to perform a wide range of movements with minimal energy consumption. In recent years, they have been increasingly called “smart friction units” due to their ability to self-repair and adapt to changing operating conditions. However, in reality, the elements of the internal structure of the joints under the influence of many factors can degrade rather quickly, leading to serious disease such as osteoarthritis. According to the World Health Organization, osteoarthritis is already one of the 10 most disabling diseases in developed countries. In this regard, at present, fundamental research on synovial joints remains highly relevant. Despite the fact that the synovial joints have already been studied fully, many issues related to their operating, prevention, development of pathology, diagnosis and treatment require more detailed consideration. In this article, we discuss the urgent problems that need to be solved for the development of new pharmacological agents, biomaterials, scaffolds, implants and rehabilitation devices for the prevention, rehabilitation and improvement of the treatment effectiveness of synovial joints at various stages of osteoarthritis.

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Central regulation of pain in patients with joint disease and approaches to therapy

Филатова¹,

Эрдес²,

Филатова³

2016

Terapevticheskii arkhiv

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The paper reviews investigations studies that have demonstrated that chronic pain syndrome is mixed in rheumatic diseases. The nervous system is involved in its pathogenesis with different frequency and different mechanisms. Under the influence of afferent pain impulses from damaged joints, there are changes in the excitability of spinal cord neurons, which is called central sensitization (CS). A number of patients have enhanced CS and clinical manifestations as neuropathic sensitive phenomena. The mixed model of the development of chronic pain in joint diseases and its presence along with nociceptive (inflammatory) and neuropathic pain components may explain the discrepancy between joint inflammatory and structural changes and pain intensity, the presence of distant pain and sensitive disorders in the areas outside the joint, and sometimes the efficiency of anti-inflammatory therapy. The presence of the neuropathic pain component serves as a rationale for combined therapy by adding centrally acting drugs, such as anticonvulsants.

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Current Ideas About the Pathogenetic Mechanisms of Pain in Osteoarthrosis

Cited by 4 publications

References 25 publications

Successful experience of transcatheter arterial embolization for gonarthrosis in patients with severe pain syndrome and ineffectiveness of conservative therapy

Successful experience of transcatheter arterial embolization for gonarthrosis in patients with severe pain syndrome and ineffectiveness of conservative therapy

Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

Central regulation of pain in patients with joint disease and approaches to therapy

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