Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

Popov, Valentin L.; Poliakov, Aleksandr; Pakhaliuk, Vladimir

doi:10.3390/lubricants9020015

Cited by 26 publications

(12 citation statements)

References 82 publications

(100 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Artificial joints are used to replace the malfunctioning bones, enabling thousands of people to enjoy an active lifestyle [ 1 , 2 , 3 , 4 ]. The latest technologies in the field of joint replacement include bone integration of artificial joints, improvements in bone replacement materials, implants, and rehabilitation devices, and joint replacement technology based on dynamic bone synthesis models [ 5 , 6 ]. New bone materials, such as PVA-H [ 7 , 8 , 9 ] and UHMWPE, with a high modulus of elasticity, biocompatibility, and mechanical properties, were studied systematically and in depth [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Fan

Xiuqin

et al. 2021

Materials

View full text Add to dashboard Cite

Ultrahigh molecular weight polyethylene (UHMWPE) materials have been prevalent joint replacement materials for more than 45 years because of their excellent biocompatibility and wear resistance. In this study, functionalized activated nanocarbon (FANC) was prepared by grafting maleic anhydride polyethylene onto acid-treated activated nanocarbon. A novel porous UHMWPE composite was prepared by incorporating the appropriate amount of FANC and pore-forming agents during the hot-pressing process for medical UHMWPE powder. The experimental results showed that the best prepared porous UHMWPE/FANC exhibited appropriate tensile strength, porosity, and excellent hydrophilicity, with a contact angle of 65.9°. In vitro experiments showed that the porous UHMWPE/FANC had excellent biocompatibility, which is due to its porous structure and hydrophilicity caused by FANC. This study demonstrates the potential viability for our porous UHMWPE/FANC to be used as cartilage replacement material for biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Fan

Xiuqin

et al. 2021

Materials

View full text Add to dashboard Cite

show abstract

“…As the compressive load increases, interstitial fluid begins to be released from the AC, which leads to a redistribution of some of the load on the solid ECM and to its consolidation. Upon reaching equilibrium, the flow of interstitial fluid from the AC stops, and the ECM takes over the entire load [19]. This effect is known as stress relaxation in AC and characterizes one of its most important characteristics, which determine the compression process and support functions [20].…”

Section: Fig 1 Schematic Cross-sectional Diagram Of Healthy Articular...mentioning

confidence: 99%

One-Dimensional Biological Model of Synovial Joints Regenerative Rehabilitation in Osteoarthritis

Popov

Poliakov²,

Pakhaliuk³

2022

FU Mech Eng

Self Cite

View full text Add to dashboard Cite

This work is devoted to the study of a one-dimensional phenomenological model of a focal defect regenerative rehabilitation in the articular cartilage. The model is based on six differential equations in partial derivatives of the “Diffusion-Reaction” type, which was previously used by a number of authors to study cellular processes in various tissues under cell therapy conditions. To take into account the influence of moderate mechanical stimulation of immature tissue, an indirect approach was used, as a result of which some model parameters that directly affect cell proliferation and differentiation were varied considering experimental data. The results of the model study show that moderate stimulation of immature tissue in the early stages of repair the focal articular cartilage defect under conditions of cell therapy leads to an intensification of regenerative processes in the tissue and promotes more rapid formation of the extracellular matrix.

show abstract

“…In this paper, we study a mathematical model of regenerative rehabilitation the local articular cartilage defects, taking into account the features of this type of skeletal connective tissue, which are well studied and described in detail in many literature sources (3)(4)(5)(6)(7). It also takes into account the responses of chondrocytes and progenitor chondrocytes observed in experiments in vitro to a wide range of mechanical stimuli, including tensile, compressive, shear deformations, fluid flow, hydrostatic and osmotic pressure (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

In silico evaluation of the mechanical stimulation effect on the regenerative rehabilitation for the articular cartilage local defects

Popov

Poliakov²,

Pakhaliuk³

2023

Front. Med.

Self Cite

View full text Add to dashboard Cite

Osteoarthritis is one of the most severe diseases of the human musculoskeletal system, and therefore, for many years, special attention has been paid to the search for effective methods of its treatment. However, even the most modern methods only in a limited number of cases in the early or intermediate stages of osteoarthritis lead to positive treatment results. In the later stages of development, osteoarthritis is practically incurable and most often ends with disability or the need for joint replacement for a large number of people. One of the main reasons hindering the development of osteoarthritis treatment methods is the peculiarities of articular cartilage, in which there is practically no vascular network and tissue homeostasis is carried out mainly due to the diffusion of nutrients present in the synovial fluid. In modern medicine, for the treatment of osteoarthritis, tissue engineering strategies have been developed based on the implantation of scaffolds populated with chondrogenic cells into the area of the defect. In vitro studies have established that these cells are highly mechanosensitive and, under the influence of mechanical stimuli of a certain type and intensity, their ability to proliferate and chondrogenesis increases. This property can be used to improve the efficiency of regenerative rehabilitation technologies based on the synergistic combination of cellular technologies, tissue engineering strategies, and mechanical tissue stimulation. In this work, using a regenerative rehabilitation mathematical model of local articular cartilage defects, numerical experiments were performed, the results of which indicate that the micro-and macro environment of the restored tissue, which changes during mechanical stimulation, has a significant effect on the formation of the extracellular matrix, and, consequently, cartilage tissue generally. The results obtained can be used to plan strategies for mechanical stimulation, based on the analysis of the results of cell proliferation experimental assessment after each stimulation procedure in vivo.

show abstract

Synovial Joints. Tribology, Regeneration, Regenerative Rehabilitation and Arthroplasty

Cited by 26 publications

References 82 publications

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

Porous Ultrahigh Molecular Weight Polyethylene/Functionalized Activated Nanocarbon Composites with Improved Biocompatibility

One-Dimensional Biological Model of Synovial Joints Regenerative Rehabilitation in Osteoarthritis

In silico evaluation of the mechanical stimulation effect on the regenerative rehabilitation for the articular cartilage local defects

Contact Info

Product

Resources

About