Current imaging concepts in pediatric osteomyelitis

Blickman, Johan G.; Die, C.E. van; Rooy, J.W.J. de

doi:10.1007/s00330-003-2032-3

Cited by 73 publications

(63 citation statements)

References 13 publications

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“…Additional early changes are as follows: periosteal thickening/elevation, lytic lesions, osteopenia, loss of trabecular architecture, and new bone apposition [35]. Of importance, destructive bone changes do not appear until 7 to 14 days of disease [25].…”

Section: Imaging Techniquesmentioning

confidence: 99%

“…In neonates acute hematogenous osteomyelitis and septic arthritis co-exist in up to 76% of all cases as a result of this unique vascular anatomy of the epiphysis; the bone marrow compartment is seldom involved [10,24]. The epiphysis receives its blood supply directly from metaphyseal blood vessels (transphyseal vessels) and the adjacent cartilaginous growth plate is traversed by capillaries, allowing spread of the pathogenic bacteria to the physis, epiphysis and joint and resulting in slipped epiphyses, fractures, premature physeal closure and chronic infection ( Figure 1) [25].…”

Section: Pathogenesismentioning

confidence: 99%

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Neonatal Osteomyelitis

Kiechl‐Kohlendorfer¹,

Griesmaier²

2013

Neonatal Bacterial Infection

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Section: Imaging Techniquesmentioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Neonatal Osteomyelitis

Kiechl‐Kohlendorfer¹,

Griesmaier²

2013

Neonatal Bacterial Infection

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“…A technetium (99 m Tc) radionuclide bone scan also has high sensitivity and specificity in the diagnosis of OM, 33 but, as a result of the radiation burden, is now used less often except in difficult cases, and is not useful in discitis. In SA, a bone scan may be used to exclude underlying OM following aspiration and commencement of empirical therapy.…”

Section: Imagingmentioning

confidence: 99%

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Sukhtankar

Arch

Ahmad

et al. 2017

Health Technol Assess

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Declared competing interests of authors: Saul N Faust was UK chief investigator and University Hospital Southampton NHS Foundation Trust principal investigator for a Cubist-sponsored clinical trial of daptomycin against standard of care antibiotic therapy in paediatric osteomyelitis. All funds were paid into accounts within the NHS trust or university and not paid as personal fees. He reports consultancy fees for advisory board participation paid into accounts within the NHS trust or university (not personal fees) from vaccine manufacturers and antimicrobial agent manufacturers, including AstraZeneca, Cubist, Merck, GlaxoSmithKline (GSK) and Pfizer, outside the submitted work. He acts as principal investigator for clinical trials and other studies conducted on behalf of University Hospital Southampton NHS Foundation Trust/ University of Southampton that are sponsored by vaccine manufacturers and antimicrobial agents, and has participated in advisory boards for vaccine manufacturers. Adam Finn reports grants and personal fees from Sanofi Pasteur MSD Ltd (SPMSD), and grants and personal fees from GSK, outside the submitted work. In addition, prior to October 2014, the University of Bristol and University Hospitals Bristol NHS Foundation Trust received funding for research conducted by Adam Finn and for consultancy and lectures from Pfizer, GSK, SPMSD and Novartis, who manufacture licensed and developmental meningococcal vaccines. Stuart C Clarke acts as principal investigator for clinical trials and other studies conducted on behalf of University Hospital Southampton NHS Foundation Trust/University of Southampton that are sponsored by vaccine manufacturers but receive no personal payments from them. He has participated in advisory boards for vaccine manufacturers and has received financial assistance from vaccine manufacturers to attend conferences, but receives no personal payments for this work. All grants and honoraria are paid into accounts within the respective NHS trusts or universities. Jethro Herberg reports that he was an investigator for a Cubist-sponsored clinical trial of daptomycin against standard of care antibiotic therapy in paediatric osteomyelitis; he received no personal payments. Andrew Riordan reports that the trust, but not he, has received funding for research sponsored by vaccine manufacturers and antimicrobial agents. He was lead editor for an e-learning package on meningitis produced by the Royal College of Paediatric and Child Health, funded by an unrestricted grant from Novartis Vaccines. Marieke Emonts was Newcastle upon Tyne Hospitals Foundation Trust's principal investigator for a Cubist-sponsored clinical trial of daptomycin against standard of care antibiotic therapy in paediatric osteomyelitis. All grants and honoraria are paid into accounts within the NHS trust or university; she received no personal payment of any kind. Marieke Emonts reports acting as site principle investigator on behalf of the Newcastle upon Tyne Hospitals Foundation Trust/Newcastle University for clinical tr...

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“…Presentation is more insidious, with symptoms present for 2 weeks or longer [ 6 ]. Instead of the exuberant infl ammatory process often encountered in acute osteomyelitis, the infection is more localized, usually confi ned to the metaphysis, and shows little periosteal thickening.…”

Section: Subacute Osteomyelitis (Box 192)mentioning

confidence: 96%

“…One third of osteomyelitis cases present before age 2 [ 6 ]. Osteomyelitis is twice as common in boys as in girls; there is no sex predilection for septic arthritis [ 6 ].…”

mentioning

confidence: 99%

Musculoskeletal Infection

Stein-Wexler

2014

Pediatric Orthopedic Imaging

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Manifestation of musculoskeletal infection in children depends on the developmental anatomy of bones and in particular its changing vascular supply. Thus, it is essential to understand this process thoroughly. Osteomyelitis, septic arthritis, and cellulitis are relatively common. There are three accepted stages of osteomyelitisacute, subacute, and chronic. Each has a unique presentation and imaging appearance, but they can be confused with other entities. Radiology, ultrasound, nuclear imaging, CT, and MRI each play a critical role depending on the clinical scenario and the suspected pathogen. Much of this discussion focuses on common bacterial infections (including methicillin-resistant Staphylococcus aureus ), but meningococcemia, tuberculosis, fungal infections, and syphilis are also discussed. In addition, the chapter presents manifestations of osteomyelitis in unique locations, such as the epiphysis, the pelvis, and the spine, and in unique patient populations, such as those with sickle-cell disease. Although chronic recurrent multifocal osteomyelitis is auto-infl ammatory rather than infectious, we include it here as well.

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Current imaging concepts in pediatric osteomyelitis

Cited by 73 publications

References 13 publications

Neonatal Osteomyelitis

Neonatal Osteomyelitis

Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study

Musculoskeletal Infection

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