Current Management of Oligometastatic Lung Cancer and Future Perspectives: Results of Thermal Ablation as a Local Ablative Therapy

Ghosn, M.; Solomon, Stephen B.

doi:10.3390/cancers13205202

Cited by 22 publications

(7 citation statements)

References 109 publications

(171 reference statements)

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“…Such patients may be suitable candidates for percutaneous minimally invasive ablation. Commonly used ablation methods include radiofrequency ablation, MWA, and cryoablation (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Long-term outcome following microwave ablation of lung metastases from colorectal cancer

et al. 2022

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PurposeTo retrospectively evaluate the safety and efficacy of percutaneous computed tomography (CT)-guided microwave ablation (MWA) in colorectal cancer (CRC) lung metastases, and to analyze prognostic factors.Materials and methodsData were collected from 31 patients with CRC lung metastases from May 2013 to September 2017. They had removed the CRC, no extrapulmonary metastases, no more than three metastases in the lung, the maximum diameter of the lesions was ≤3 cm, and all the lung metastases could be completely ablated. The ablation procedures were performed using a KY-2000 microwave multifunctional therapeutic apparatus. Efficacy is assessed two to four weeks after ablation, and follow-up are performed every three months for two years. The primary outcome was overall survival (OS). The secondary outcomes were progression-free survival (PFS), and complications. Cox regression analysis was used for the evaluation of the statistical significance of factors affecting the end result of MWA therapy. The Kaplan–Meier method was used for estimation of survival rates.ResultsA total of 45 metastatic lung lesions from CRC in 31 patients were treated with CT-guided MWA procedures. The median OS was 76 months. The one, two, three, and five-year survival rates were 93.5%, 80.6%, 61.3%, and 51.6%, respectively. Multivariate analysis showed that the primary tumor from the rectum (P = 0.009) and liver metastases at the diagnosis of lung metastases (P = 0.043) were risk factors affecting OS, while PFS was a protective factor. The median PFS was 13 months. The maximum diameter of lung metastases lesions (P = 0.004) was a risk factor. The interval between pulmonary metastases and MWA (P=0.031) was the protective factor. Pneumothorax was observed in 13 out of 36 procedures. Four patients developed pneumothorax requiring drainage tube insertion. No patient deaths occurred within 30 days of ablation. Three out of 31 patients (9.67%) were found to have local recurrence of the original lung metastatic ablation foci.ConclusionMWA therapy may be safely and effectively used as a therapeutic tool for the treatment of selected CRC pulmonary metastases, and the prognosis is better in patients without liver metastases at the diagnosis of lung metastases.

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“…Such patients may be suitable candidates for percutaneous minimally invasive ablation. Commonly used ablation methods include radiofrequency ablation, MWA, and cryoablation (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Long-term outcome following microwave ablation of lung metastases from colorectal cancer

et al. 2022

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“…However, the thermal deposition effect [heat-sink effect (HSE); that is, the temperature of the ablation zone is decreased when tumors are located near blood vessels or bronchia] reduces the efficacy of RFA. Therefore, when the tumor is near blood vessels or bronchia ( 17 , 18 ), the complete ablation rate of RFA will decrease ( 19 ). At the same time, RFA may cause skin cauterization, which is one of the major side effects of RFA ( 20 ).…”

Section: Commonly Used Local Ablation Treatmentmentioning

confidence: 99%

Recent Perspectives on the Mechanism of Recurrence After Ablation of Hepatocellular Carcinoma: A Mini-Review

Yang

2022

Front. Oncol.

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Hepatectomy, liver transplantation, and ablation are the three radical treatments for early-stage hepatocellular carcinoma (ESHCC), but not all patients are fit for or can tolerate surgery; moreover, liver donors are limited. Therefore, ablation plays an important role in the treatment of ESHCC. However, some studies have shown that ablation has a higher local recurrence (LR) rate than hepatectomy and liver transplantation. The specific mechanism is unknown. The latest perspectives on the mechanism of recurrence after ablation of HCC were described and summarized. In this review, we discussed the possible mechanisms of recurrence after ablation of HCC, including epithelial–mesenchymal transition (EMT), activating autophagy, changes in non-coding RNA, and changes in the tumor microenvironment. A systematic and comprehensive understanding of the mechanism will contribute to the research and development of related treatment, combined with ablation to improve the therapeutic effect in patients with ESHCC.

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“…After cryoablation of the tumor, tumor antigen is activated and exposed antitumor cytotoxic antibody produces and induces cytotoxic T cell immunity, which enhances the anti-tumor immune response of patients, thereby eliminating residual or metastatic lesions, reducing or preventing recurrence ( Figure 1 ). Therefore, theoretically cryoablation can prolong the survival of patients ( 18 ).…”

Section: Cryoablationmentioning

confidence: 99%

Cryoablation and immune synergistic effect for lung cancer: A review

Tian

Jiang

et al. 2022

Front. Immunol.

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The preferred treatment for lung cancer is surgical resection, but a large number of patients are not suitable for surgical resection in clinic. CT-guided cryoablation and immunotherapy can play an important role in patients with advanced lung cancer who are ineligible for surgery. CT-guided cryoablation has been widely used in the clinical treatment of lung tumors due to its advantages of less trauma, fewer complications, significant efficacy and rapid recovery. Cryoablation can not only cause tumor necrosis and apoptosis, but also promote the release of tumor-derived autoantigens into the blood circulation, and stimulate the host immune system to produce a good anti-tumor immune effect against primary and metastatic tumors. Since the study of immune checkpoint inhibitors has proved that lung cancer can be an immunotherapeutic response disease, the relationship between cryoablation and immunotherapy of lung cancer has been paid more attention. Therefore, we reviewed the literature on cryoablation for lung cancer, as well as the research progress of cryoablation combined with immunotherapy.

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Current Management of Oligometastatic Lung Cancer and Future Perspectives: Results of Thermal Ablation as a Local Ablative Therapy

Cited by 22 publications

References 109 publications

Long-term outcome following microwave ablation of lung metastases from colorectal cancer

Long-term outcome following microwave ablation of lung metastases from colorectal cancer

Recent Perspectives on the Mechanism of Recurrence After Ablation of Hepatocellular Carcinoma: A Mini-Review

Cryoablation and immune synergistic effect for lung cancer: A review

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