Current Naturopathy to Combat Alzheimer’s Disease

Abstract

Neurodegeneration is the progressive loss of structure or function of neurons, which may ultimately involve cell death. The most common neurodegenerative disorder in the brain happens with Alzheimer’s disease (AD) which is the most common cause of dementia. It ultimately leads to neuronal death, thereby impairing the normal functionality of the central or peripheral nervous system. The onset and prevalence of AD involve heterogeneous etiology, either in terms of genetic predisposition, neuro-metabolomic malfunctioning, or lifestyle. The worldwide relevancies are estimated to be over 45 million people. The rapid increase in AD has led to a concomitant increase in the research work, directed towards the discovery of a lucrative cure for AD. The neuropathology of AD comprises the deficiency in the availability of neurotransmitters and important neurotrophic factors in the brain, extracellular beta-amyloid plaque depositions, and intracellular neurofibrillary tangles of hyperphosphorylated tau protein. Current pharmaceutical interventions utilizing synthetic drugs have manifested resistance and toxicity problems. This has led to the quest for new pharmacotherapeutic candidates naturally prevalent in phyto chemicals. This review aims to provide an elaborative description of promising phyto component entities having activities against various potential AD targets. Therefore, naturopathy may combine with synthetic chemotherapeutics to longer the survival of the patients.

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer’s disease proteopathology for precision medication

“…We observed that MS1262 treatment suppressed Tau expression that is characteristically increased in AD brains. Because neurofibrillary tangles composed of abnormally hyperphosphorylated Tau are a hallmark of AD, 61 this result demonstrated the specificity of MS1262 in targeting AD tauopathy.…”

Phytochemical composition and biological activity of native Australian ginger (Alpinia caerulea)

“…The AChE inhibitory activity of (E)-8 (17),12-labdadiene-15,16-dial or zerumin A does not appear to be reported, although zerumin A does show neuroprotective activity by preventing oxidative damage to cells [67]. Zerumin A is also reportedly a positive modulator of GABA A receptors, providing it with potential therapeutic activity against Alzheimer's disease [68]. Consequently, it is possible that one of these diterpenoids may be responsible for the AChE inhibition of A. caerulea.…”