Current Neurological Observations and Complications of Dengue Virus Infection

Solbrig, Marylou V.; Perng, Guey Chuen

doi:10.1007/s11910-015-0550-4

Cited by 33 publications

(26 citation statements)

References 61 publications

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“…Dengue is recognized as a frequent or leading cause of encephalitis in endemic regions and dengue encephalitis may be the primary manifestation of infection [22, 23]. Given that there were 32,063 cases of dengue reported in Sri Lanka during the period that this study was conducted, it is not surprising that dengue has emerged as the commonest viral aetiology in our study.…”

Section: Discussionmentioning

confidence: 79%

Viral aetiologies of acute encephalitis in a hospital-based South Asian population

Lohitharajah¹,

Malavige

Arambepola

et al. 2017

BMC Infect Dis

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BackgroundThe aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population.MethodsA cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Cerebrospinal fluid and serum were tested for conventional and emerging encephalitogenic viruses. Specific nucleic acid amplification and antibody assays were used to identify viruses. Plaque reduction neutralization test was done to confirm the diagnosis of West Nile virus (WNV).ResultsPatients’ age ranged from 1 month to 73 years (mean = 24.91; SD = 21.33) with a male:female ratio of 1.75:1. A viral aetiology was identified in only 27.3%. These included dengue virus (40.7%), Japanese encephalitis virus (25.9%), varicella zoster virus, WNV and probable Epstein Barr virus (11.1% each). None were positive for herpes simplex viruses or cytomegalovirus. Screening for bacterial aetiologies was negative for all patients. There were no distinguishable clinical or laboratory findings between the different viral aetiologies. The case fatality rate was 7%, which was higher among patients with an identified viral aetiology.ConclusionsA viral aetiology was identified in only about a quarter of patients with encephalitis. Dengue virus accounted for the majority.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-017-2403-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 79%

Viral aetiologies of acute encephalitis in a hospital-based South Asian population

Lohitharajah¹,

Malavige

Arambepola

et al. 2017

BMC Infect Dis

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“…Until 2012, neurological complications of dengue virus infection were classified into three categories based on pathogenesis as proposed by Murthy, Marzia and colleages: (1) metabolic disturbance, e.g., encephalopathy; (2) viral invasion, including encephalitis, meningitis, myositis, and myelitis; (3) autoimmune reactions, including acute disseminated encephalomyelitis, neuromyelitis optica, optic neuritis, myelitis, encephalopathy, and Guillain-Barré syndrome (Murthy, 2010 ; Puccioni-Sohler et al, 2012 ). In recent years, Solbrig et al reported neurological involvements of the CNS and eyes, associated peripheral nervous system (PNS) syndromes, and convalescent or post-dengue immune-mediated syndromes (Solbrig and Perng, 2015 ; Maurya et al, 2016 ).…”

Section: Neuropathogenesismentioning

confidence: 99%

“…CNS complications are diagnosed by assessing anti-DENV immunoglobulin (Ig)M, detecting viral RNA or non-structural protein 1 (NS1)in the CSF, isolating the virus from the CSF, and after excluding other causative agents of viral brain diseases (Sahu et al, 2014 ; Solbrig and Perng, 2015 ). Misra et al found that CNS involvement reflects severer disease with poorer recovery (Misra et al, 2015 ).…”

Section: Central Neurological System Complicationsmentioning

confidence: 99%

Neurological Manifestations of Dengue Infection

Zhang

Liu

et al. 2017

Front. Cell. Infect. Microbiol.

161

146

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Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS), peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis. In addition, neurological complications in children were assessed due to their atypical clinical features. Finally, dengue infection and Japanese encephalitis were compared for pathogenesis and main clinical manifestations.

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“…DENV is not generally considered neurotropic but has also been associated with neurologic disease [78]. Of the mosquito-borne flaviviruses, the neurological complications arising from JEV and WNV infection are documented best.…”

Section: Introductionmentioning

confidence: 99%

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

Cumberworth¹,

Barrie²,

Cunningham³

et al. 2017

acta neuropathol commun

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The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are the subject of intense research; however, even the principal neural cell types vulnerable to productive Zika infection remain poorly characterised. Here we used CNS and PNS myelinating cultures from wild type and Ifnar1 knockout mice to examine neuronal and glial tropism and short-term consequences of direct infection with a Brazilian variant of ZIKV. Cell cultures were infected pre- or post-myelination for various intervals, then stained with cell-type and ZIKV-specific antibodies. In bypassing systemic immunity using ex vivo culture, and the type I interferon response in Ifnar1 deficient cells, we were able to evaluate the intrinsic infectivity of neural cells. Through systematic quantification of ZIKV infected cells in myelinating cultures, we found that ZIKV infection is enhanced in the absence of the type I interferon responses and that CNS cells are considerably more susceptible to infection than PNS cells. In particular, we demonstrate that CNS axons and myelinating oligodendrocytes are especially vulnerable to injury. These results have implications for understanding the pathobiology of neurological symptoms associated with ZIKV infection. Furthermore, we provide a quantifiable ex vivo infection model that can be used for fundamental and therapeutic studies on viral neuroinvasion and its consequences.Electronic supplementary materialThe online version of this article (doi:10.1186/s40478-017-0450-8) contains supplementary material, which is available to authorized users.

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Current Neurological Observations and Complications of Dengue Virus Infection

Cited by 33 publications

References 61 publications

Viral aetiologies of acute encephalitis in a hospital-based South Asian population

Viral aetiologies of acute encephalitis in a hospital-based South Asian population

Neurological Manifestations of Dengue Infection

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected

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