Current Opinions in the Treatment of Pulmonary Nontuberculous Mycobacteria in Non-Cystic Fibrosis Patients: Mycobacterium abscessus Group, Mycobacterium avium Complex, and Mycobacterium kansasii

Philley, Julie V.; Benwill, Jeana L.; Wallace, Richard J.

doi:10.1007/s40506-014-0032-2

Cited by 4 publications

(3 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The newer and more expensive macrolides (i.e., azithromycin and clarithromycin) and quinolones (i.e., ofloxacin and ciprofloxacin) have become the cornerstones of therapy for the most clinically important NTM (Brown-Elliott et al, 2012 ). Recent studies have also shown the high prevalence of drug resistance in NTM species that threatens adequate control of the disease (Brown-Elliott et al, 2012 , 2014 ; Cândido et al, 2014 ; Cowman et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

et al. 2017

View full text Add to dashboard Cite

Infectious diseases caused by clinically important Mycobacteria continue to be an important public health problem worldwide primarily due to emergence of drug resistance crisis. In recent years, the control of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (MTB), is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least isoniazid (INH) and rifampicin (RIF), two key drugs in the treatment of the disease. Despite the availability of curative anti-TB therapy, inappropriate and inadequate treatment has allowed MTB to acquire resistance to the most important anti-TB drugs. Likewise, for most mycobacteria other than MTB, the outcome of drug treatment is poor and is likely related to the high levels of antibiotic resistance. Thus, a better knowledge of the underlying mechanisms of drug resistance in mycobacteria could aid not only to select the best therapeutic options but also to develop novel drugs that can overwhelm the existing resistance mechanisms. In this article, we review the distinctive mechanisms of antibiotic resistance in mycobacteria.

show abstract

Section: Introductionmentioning

confidence: 99%

New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Treatment protocols for psittacine birds are based on those used in humans [17]. At present, azithromycin is the most effective antibiotic used in the treatment of avian mycobacteriosis [47]. Recently, azithromycin combined with clofazimine showed a strong in vitro antibacterial activity against M. avium [35,48].…”

Section: Prevention and Treatmentmentioning

confidence: 99%

A review of avian mycobacteriosis: An emerging bacterial disease of public health concern

El-Ghany

2022

Int J One Health

View full text Add to dashboard Cite

Avian mycobacteriosis is a chronic debilitating disease of birds which poses a public health threat. In avian species, the disease is primarily caused by Mycobacterium avium subspecies avium. Nearly all bird species are susceptible to this infection, with older birds being more susceptible than younger ones. Ingestion of feed and water contaminated by the excreta of infected or chronic carrier birds is the main route of Mycobacterium infection and transmission; however, the respiratory route is also possible. Migratory wild or free-living birds play an important role in mycobacteriosis transmission, and affected birds show severe depletion, emaciation, anemia, diarrhea, and respiratory manifestations. The appearance of characteristic tuberculous nodules in the digestive system, especially in the intestine, liver, and spleen, is pathognomonic. Confirmation of Mycobacterium infection can be achieved through isolation on specifically selected media, direct smear for detection of characteristic acid-fast bacilli, and detection of the bacterium using molecular diagnostic methods. Serological and allergic tests can also be applied. Different species of Mycobacterium, especially M. avium, have public health significance and can be transmitted from birds to humans. Such zoonosis is especially dangerous in human immunocompromised patients. Authorities and governments have implemented strict and comprehensive eradication programs for avian mycobacteriosis. These biosecurity measures, including surveillance monitoring programs and antimicrobial susceptibility testing, are essential for the prevention and treatment of Mycobacterium infection in poultry production systems. This review was designed to focus on avian mycobacteriosis in birds and humans.

show abstract

“…The antimicrobial resistance is attributed to either intrinsic factors such as the waxy lipoid cell wall or mutation in some genes [ 27 ]. The most effective drug used in the treatment of avian tuberculosis is azithromycin [ 28 ]. Most types of M. avium complex have a weak response to the treatment due to the development of antibiotic resistance [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Emerging MDR-Mycobacterium avium subsp. avium in house-reared domestic birds as the first report in Egypt

et al. 2021

View full text Add to dashboard Cite

Background Avian tuberculosis is a chronic and zoonotic disease that affects a wide variety of birds, mammals, and humans. This study aimed to estimate the frequency of Mycobacterium avium subsp. avium in some domestic birds based on molecular diagnosis, antibiogram profile, and PCR-based detection of inhA, rpoB, rpsL, and otrB antibiotic resistance-related genes. Methods A total of 120 fecal samples were collected from small flocks of house-reared domestic birds at Ismailia Governorate, Egypt. The collected samples were processed and subjected to the bacteriological examination. The antimicrobial susceptibility testing of the recovered isolates was performed using the broth microdilution method for the detection of minimum inhibitory concentrations (MICs). The genetic detection of the IS901confirmatory gene, inhA, rpoB, rpsL, and otrB genes was carried out using PCR. Results The frequency of M. avium subsp. avium was 4.1% (5/120); 10% (4/40) in ducks, and 2.5% (1/10) in geese. The identification of the recovered isolates was confirmed using PCR, where all the tested isolates were positive for IS901confirmatory gene. The results of the broth microdilution method revealed that most of the recovered isolates exhibited multidrug resistance (MDR) to isoniazid, rifampicin, streptomycin, oxytetracycline, and doxycycline, and harbored the inhA, rpoB, rpsL, and otrB genes. Conclusion In brief, to the best of our knowledge this is the first report that emphasized the emergence of avian tuberculosis in house-reared domestic birds in Egypt. The emergence of MDR- M. avium subsp. avium is considered a public health threat. Emerging MDR-M. avium subsp. avium in domestic birds are commonly harbored the IS901, inhA, rpoB, rpsL, and otrB genes. Azithromycin and clofazimine revealed a promising in-vitro antibacterial activity against M. avium subsp. avium.

show abstract

Current Opinions in the Treatment of Pulmonary Nontuberculous Mycobacteria in Non-Cystic Fibrosis Patients: Mycobacterium abscessus Group, Mycobacterium avium Complex, and Mycobacterium kansasii

Cited by 4 publications

References 58 publications

New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

A review of avian mycobacteriosis: An emerging bacterial disease of public health concern

Emerging MDR-Mycobacterium avium subsp. avium in house-reared domestic birds as the first report in Egypt

Contact Info

Product

Resources

About