Current Perspectives on Nasopharyngeal Carcinoma

Lee, Hui Mei; Okuda, Kazuhide S.; González, Fermín E.; Patel, Vyomesh

doi:10.1007/978-3-030-22254-3_2

Cited by 157 publications

(135 citation statements)

References 149 publications

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“…Nasopharyngeal carcinoma (NPC) is very prone to lymph node metastasis [13]. Some studies have reported that approximately 40% of patients with NPC have a first symptom of cervical lymphadenopathy [14]. Approximately 60 to 90% of patients with newly diagnosed NPC have lymph node metastasis [15].…”

Section: Discussionmentioning

confidence: 99%

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

Jiang¹,

Gao²,

Zhang³

et al. 2020

BMC Cancer

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Background: Lymph node metastasis in the cervical region posterior to level V (PLV) can occurs in patients with nasopharyngeal carcinoma (NPC), but the significance of lymph node metastasis in this region and the delineation of the radiotherapy target area have not been reported. We aimed to explore the distribution pattern and prognosis of metastatic lymph nodes in the PLV region in patients with NPC. Methods: We retrospectively studied 605 cases of NPC diagnosed by pathological detection from December 2011 to November 2017. The nodal distribution at each level was assessed in accordance with the Radiation Therapy Oncology Group (RTOG) guidelines proposed in 2013. The central points of the metastatic lymph nodes of the PLV region in the patients were recreated proportionally on the CT images of a standard patient with N0 NPC in reference to the normal anatomy of the PLV area. The correlation between the PLV region and the other levels, the nodal location, and the characteristics and prognosis of the PLV region were analyzed. Results: Lymph node metastasis occurred in 557 (92.06%) of 605 patients. There were 30 patients (4.95%) with lymph node metastasis in the PLV region. A total of 49 metastatic lymph nodes from the PLV region were counted, and the mean vertical distance of the central point of each lymph node from the anterior surface of the trapezius muscle was 14 mm. Linear regression correlation analysis suggested that lymph node metastasis in the PLV region was associated with ipsilateral level IVa (P = 0.018), level Va, level Vb, and level Vc lymph node metastasis (all P < 0.001). The 5-year OS, PFS, LRFS, and DMFS of 29 patients with lymph node metastasis in the PLV region were 41.6, 27.7, 89.1, and 47.3%, respectively. Multivariate analysis showed that lymph node metastasis in the PLV region was an independent prognostic factor for DMFS (P < 0.05). Conclusion: NPC patients with lymph node metastasis in the PLV region had a poor prognosis and a high risk of distant metastasis. We recommend that the margin of the PLV region may be a new cervical lymph node segment for NPC.

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Section: Discussionmentioning

confidence: 99%

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

Jiang¹,

Gao²,

Zhang³

et al. 2020

BMC Cancer

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“…Nasopharyngeal carcinoma (NPC) is the most common head and neck malignancy develops from the epithelial cells of the nasopharynx. 1 NPC is characterized by unique genetic, highly metastatic feature and unique geographical distribution, with the highest incidence rate among the Cantonese living in Southern China, Southeast Asia. 2 NPC has a high possibility of distant metastasis, while more than 70% of patients develop regional lymph node metastasis at the time of diagnosis, almost 20% of patients develop distant metastasis, mainly to the lungs or liver.…”

Section: Introductionmentioning

confidence: 99%

<p>MiR-154-5p Suppresses Cell Invasion and Migration Through Inhibiting KIF14 in Nasopharyngeal Carcinoma</p>

Chen¹,

Ma²,

Zhang³

et al. 2020

OTT

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Background: Mounting evidence has reported that microRNA-154-5p (miR-154-5p) is involved in the development of multiple cancers, but its function in nasopharyngeal carcinoma (NPC) remains not well investigated. Methods: Real-time quantitative PCR (qRT-PCR) was used to detect miR-154-5p expression in NPC tissues and cells. CCK8, colony formation, wound healing and transwell assays were performed to assess cell proliferation, migration and invasion. Dual-luciferase reporter assays and Western blots were performed to confirm the target gene of miR-154-5p. Rescue experiments were conducted to explore the influence of target gene KIF14 on the functions of miR-154-5p. Xenograft tumor model was conducted to detect the effect of miR-154-5p in vivo. Results: qRT-PCR results revealed that the expression of miR-154-5p was down-regulated in NPC tissues and cell lines compared to normal nasopharyngeal tissues and cell line. Overexpression of miR-154-5p inhibited cell migration and invasion. However, miR-154-5p had no influence on the proliferation of NPC cells. MiR-154-5p overexpression suppressed xenograft tumor metastasis in vivo. Dual-luciferase reporter analysis identified KIF14 as a target gene of miR-154-5p. Rescue experiments showed that knockdown of KIF14 reversed the effect of inhibiting miR-154-5p expression on NPC cell migration and invasion. Conclusion: Taken together, miR-154-5p suppresses tumor migration and invasion by targeting KIF14 in NPC. The newly identified miR-154-5p/KIF14 interaction offers further insights into the progression of NPC, which may represent a novel target for NPC diagnosis and treatment.

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“…Nasopharyngeal carcinoma (NPC) is very prone to lymph node metastasis [13] . Some studies have reported that approximately 40% of patients with NPC have a rst symptom of cervical lymphadenopathy [14] . Approximately 60% to 90% of patients with newly diagnosed NPC have lymph node metastasis [15] .…”

Section: Discussionmentioning

confidence: 99%

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

Jiang¹,

Gao²,

Zhang³

et al. 2020

Preprint

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Lymph node metastasis in the cervical region posterior to level V (PLV) often occurs in patients with nasopharyngeal carcinoma (NPC), but the significance and the delineation of the radiotherapy target area have not been reported. We retrospectively studied 605 cases of NPC. A total of 49 metastatic lymph nodes from the PLV region were counted. Linear regression correlation analysis suggested that lymph node metastasis in the PLV region was associated with ipsilateral level IVa, level Va, level Vb, and level Vc lymph node metastasis (all P<0.05). The 5-year OS, PFS, LRFS, and DMFS of patients with N3 NPC with or without lymph node metastasis in the PLV region were 41.8% vs 67.3% (P=0.007), 27.8% vs 48.5% (P=0.005), 92.3% vs 80.5% (P=0.521), 40.6% vs 78.4% (P<0.001), respectively. Multivariate analysis showed that lymph node metastasis in the PLV region was an independent prognostic factor for DMFS (P<0.05). In summary, NPC patients with lymph node metastasis in the PLV region had a poor prognosis and a high risk of distant metastasis. When patients have lymph node metastasis in levels IVa and V, the posterior boundary of the radiotherapy target in ipsilateral level V should be appropriately moved backward. We recommend that the margin of the PLV region may be a new cervical lymph node segment for head and neck tumors.

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Current Perspectives on Nasopharyngeal Carcinoma

Cited by 157 publications

References 149 publications

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

<p>MiR-154-5p Suppresses Cell Invasion and Migration Through Inhibiting KIF14 in Nasopharyngeal Carcinoma</p>

Distribution pattern and prognosis of metastatic lymph nodes in cervical posterior to level V in nasopharyngeal carcinoma patients

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