Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

Tabassum, Rukhsana; Ashfaq, Muhammad; Oku, Hiroyuki

doi:10.2174/1389557520999201214234735

Cited by 33 publications

(14 citation statements)

References 158 publications

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“…Quinoline core ( Figure 1 ), a bicyclic structure in which a pyridinic ring is fused to a benzene moiety, occurs in several natural compounds ( Cinchona alkaloids) and in drugs, with a broad range of biological activities including antimicrobial, antifungal, antitumor, antiviral, anticholesterol and anti-Alzheimer’s disease 15 , 16 . The 8-hydroxy quinoline derivatives clioquinol and PBT2 ( Figure 1 ), promising multifunctional agents, have been investigated for their neuroprotective effect in AD and have entered clinical trials for AD 17 .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and evaluation of quinoline- O -carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Chen

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of novel quinoline- O -carbamate derivatives was rationally designed for treating Alzheimer’s disease (AD) by multi-target-directed ligands (MTDLs) strategy. The target compounds were synthesised and evaluated by AChE/BuChE inhibition and anti-inflammatory property. The in vitro activities showed that compound 3f was a reversible dual ee AChE/eqBuChE inhibitor with IC 50 values of 1.3 µM and 0.81 µM, respectively. Moreover, compound 3f displayed good anti-inflammatory property by decreasing the production of IL-6, IL-1β and NO. In addition, compound 3f presented significant neuroprotective effect on A β 25-35 -induced PC12 cell injury. Furthermore, compound 3f presented good stabilities in artificial gastrointestinal fluids, liver microsomes in vitro and plasma. Furthermore, compound 3f could improve AlCl 3 -induced zebrafish AD model by increasing the level of ACh. Therefore, compound 3f was a promising multifunctional agent for the treatment of AD.

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Section: Introductionmentioning

confidence: 99%

Design, synthesis and evaluation of quinoline- O -carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Chen

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Quinolines are one of the most important classes of heterocyclic alkaloids, which have been widely reported to possess a broad range of pharmaceutical activities [ 4 , 5 ]. Quinoline-bearing structures exist in many biologically active drugs, including Quinine, Quinodine, Mefloquine, and Chloroquine [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Anticancer Effect of a Novel Quinoline Derivative 91b1 through Downregulation of Lumican

Zhou

Chan

et al. 2022

IJMS

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Quinoline derivatives have been reported to possess a wide range of pharmaceutical activities. Our group previously synthesized a series of quinoline compounds, in which compound 91b1 showed a significant anticancer effect. The purpose of this study was to evaluate the anticancer activity of compound 91b1 in vitro and in vivo, and screen out its regulated target. A series of cancer cell lines and nontumor cell lines were treated with compound 91b1 by MTS cytotoxicity assay and cell-cycle assay. In vivo anticancer activity was evaluated by a xenografted model on nude mice. Target prediction of 91b1 was assessed by microarray assay and confirmed by pancancer analysis. Relative expression of the target gene Lumican was measured by qRT-PCR. 91b1 significantly reduced tumor size in the nude mice xenograft model. Lumican was downregulated after 91b1 treatment. Lumican was proven to increase tumorigenesis in vivo, as well as cancer cell migration, invasion, and proliferation in vitro. The results of this study suggest that the anticancer activity of compound 91b1 probably works through downregulating the gene Lumican.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, due to its wide range of pharmaceutical applications, it is urgent to design new compounds containing quinoline moiety to act as potential drugs for the treatment of many diseases like cancer, dengue fever, malaria, tuberculosis, fungal infections, AIDS, Alzheimer's disease, and diabetes. [24] To continue our investigations to develop novel Schiff base derivatives that can act as potential drugs to cure various diseases, [1][2][3]5] here we report the synthesis of a new Schiff base with a quinoline part, 1-phenyl-2-((quinolin-2-ylmethylene)amino)ethanol (HL; Scheme 1) along with its coordination derivatives of some transition metal ions. The study included the synthesis and analytical and spectroscopic characterization of the Schiff base ligand and its complexes.…”

Section: Introductionmentioning

confidence: 99%

New transition metal complexes of 1‐phenyl‐2‐((quinolin‐2‐ylmethylene)amino)ethan‐1‐ol Schiff base: Spectroscopic, X‐ray, DFT, Hirshfeld surface analysis, biological, and molecular docking studies

Elantabli

El‐Medani

Kozakiewicz‐Piekarz

et al. 2022

Applied Organom Chemis

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A novel Schiff base ligand (HL), derived from the condensation of phenylethanolamine and quinoline‐2‐carboxaldehyde, and its coordination complexes with some transition metal ions, Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Pd(II), were synthesized. The reported new compounds were characterized using different analytical and spectroscopic techniques. The structure of HL and its cobalt complex was also solved by conventional X‐ray diffraction technique. Hirshfeld surface analysis of the ligand and cobalt complexes was investigated. Interesting structural features with unique hydrogen bonding formation were observed. Molecular geometries of HL and the reported complexes were investigated using the DFT‐B3LYP level of theory. The quantum global reactivity descriptors were also calculated. Biological screening and molecular docking studies of the ligand and complexes are reported to explore their potential application as therapeutic drugs. The biological studies and molecular docking were correlated to each other and with the quantum reactivity descriptors. The studies supported that the complexes could bind to DNA via intercalative mode and showed various DNA binding potency.

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Current Pharmaceutical Aspects of Synthetic Quinoline Derivatives

Cited by 33 publications

References 158 publications

Design, synthesis and evaluation of quinoline- O -carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Design, synthesis and evaluation of quinoline- O -carbamate derivatives as multifunctional agents for the treatment of Alzheimer’s disease

The Anticancer Effect of a Novel Quinoline Derivative 91b1 through Downregulation of Lumican

New transition metal complexes of 1‐phenyl‐2‐((quinolin‐2‐ylmethylene)amino)ethan‐1‐ol Schiff base: Spectroscopic, X‐ray, DFT, Hirshfeld surface analysis, biological, and molecular docking studies

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