Current pharmacotherapy for weight loss: A review and implications for plastic surgeons

Giese, Sharon Y.; Neborsky, Rebecca

doi:10.1067/maj.2001.114450

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Phentermine, which has been on the market for several decades, is part of the broader antiobesity drug class sympathomimetic amines, which act on the brain to release norepinephrine, and induces weight loss by suppressing appetite 18 . The constant preference for phentermine over newer and potentially more efficacious and safer antiobesity agents emerging onto the market can be explained by its relatively low cost and better insurance coverage.…”

Section: Discussionmentioning

confidence: 99%

Prescribing trends and clinical characteristics of patients starting antiobesity drugs in the United States

Suissa

Schneeweiß

Kim

et al. 2021

Diabetes Obesity Metabolism

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Aim: To assess the trends in the prescribing of antiobesity medications and the characteristics of patients recently initiating antiobesity drugs. Materials and Methods:We conducted a population-based cohort study using claims data from commercial health insurances in the United States. Patients initiating an antiobesity drug between January 2004 and December 2018 were included. Trends in the utilization of antiobesity medications were plotted by year, as a proportion of any antiobesity treatment, and as initiation rates per 100 000. Descriptive statistics were used to summarize the characteristics of antiobesity initiators.Results: From 2004 to 2018, 626 216 patients started an antiobesity medication (two per 100 000). Phentermine was the most frequently prescribed (50% in 2018).In recent years (2015)(2016)(2017)(2018), among 227 692 patients who initiated an antiobesity drug, 51% started phentermine, 19% naltrexone-bupropion, and 13% liraglutide 3.0 mg. Compared to other agents, the use of liraglutide 3.0 mg increased between 2015 and 2018. The average age of initiators was 45 years, 81% of initiators were female, 32% had hypertension, 25% had dyslipidaemia, and 6% had type 2 diabetes. Time on treatment was generally short (mean 81 days). Conclusion:The overall use of antiobesity medications remained low over the past 15 years and phentermine was the preferred antiobesity agent. Although the use of potentially safer antiobesity agents, for example, liraglutide 3.0 mg, has increased in recent years, phentermine remained the most frequently prescribed agent among middle-aged adults with a moderate burden of comorbidities.

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Section: Discussionmentioning

confidence: 99%