Current Proceedings of Cerebral Palsy

Fan, Hueng Chuen; Ho, Ling‐Jun; Shiang, Ching; Cheng, Shu‐Meng; Juan, Chun-Jung; Chiang, Kuo Liang; Lin, Shinn Zong; Harn, Horng Jyh

doi:10.3727/096368915x686931

Cited by 24 publications

(27 citation statements)

References 184 publications

(198 reference statements)

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“…Epidemiological studies have found that the global prevalence of CP is 1.5-4 per 1000 live births, and the prevalence is higher in poor areas [3,4]. For example, with a prevalence of 3.6 per 1000 newborns in the United States, more than one hundred thousand children are affected in this country alone [5].…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture for Children with Cerebral Palsy: A Systematic Review Protocol

et al. 2017

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BackgroundCerebral palsy (CP), a childhood disease of high morbidity and serious harmfulness, has no effective therapies to completely relieve the associated pain. Acupuncture has been used widely in China to alleviate several CP symptoms, such as pain and motion disorders, despite the deficiency of high-quality evidence related to this practice.ObjectiveThe aim of this systematic review protocol is to assess the efficacy and safety of acupuncture for the treatment of children with CP.MethodsThe following electronic databases will be searched: Cochrane Library, Web of Science, EBASE, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Wan-fang database, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and other sources. All published randomized controlled trials from inception to December 2016 will be included. RevMan V.5.3 software will be implemented for the assessment of bias risk, data synthesis, subgroup analysis, and meta-analyses if inclusion conditions are met. Individuals recruited into the trials will include children with all types of CP, and these individuals will be involved as coresearchers to develop and evaluate the efficacy and safety of acupuncture for the treatment of children with CP. Due to language barriers, only English and Chinese articles will be retrieved.ResultsThe systematic review will synthesize the available knowledge surrounding acupuncture for children with CP. The findings will be synthesized to determine the efficacy and safety of acupuncture for children with CP.ConclusionsThe review has not been completed. This protocol presents a proper method to implement the systematic review, and ensures transparency for the completed review. Findings from the systematic review will be disseminated in a peer-reviewed journal and results will be presented at relevant conferences. The data of individual patients will not be included, so ethical approval is not required.Trial RegistrationPROSPERO registration number: CRD42016038275, http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016038275 (Archived by WebCite at http://www.webcitation/6nGxoJrqm

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Section: Introductionmentioning

confidence: 99%

“…Current treatments include pharmacological interventions, surgical interventions, physical and behavioral therapy, mechanical aids, and management of associated medical conditions. Although these commonly used clinical treatments of CP are multitudinous, none have accomplished a satisfying curative effect [3]. …”

Section: Introductionmentioning

confidence: 99%

Acupuncture for Children with Cerebral Palsy: A Systematic Review Protocol

et al. 2017

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“…Thymus derived T-cells (myelin reactive) migrate to the blood brain barrier and stimulate an inflammatory cascade in the CNS [3]. …”

Section: Introductionmentioning

confidence: 99%

Transplantation of Human Embryonic Stem Cells in Patients with Multiple Sclerosis and Lyme Disease

Shroff¹

2016

Am J Case Rep

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Case seriesPatient: Male, 42 • Female, 30Final Diagnosis: Human embryonic stem cells showed good therapeutic potential for treatment of multiple sclerosis with lyme diseaseSymptoms: Fatigue • weakness in limbsMedication: —Clinical Procedure: Human embryonic stem cells transplantationSpecialty: TransplantologyObjective:Rare diseaseBackground:Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease in which the myelin sheath of nerve cells is damaged. It can cause delayed neurologic symptoms similar to those seen in Lyme disease (LD) patients. Thymus derived T-cells (myelin reactive) migrate to the blood brain barrier and stimulate an inflammatory cascade in the central nervous system. Cell based therapies play an important role in treating neurological diseases such as MS and LD.Case Report:Human embryonic stem cell (hESC) therapy was used to treat two patients with both MS and LD. The hESCs were administered via different routes including intramuscular, intravenous, and supplemental routes (e.g., deep spinal, caudal, intercostal through eye drops) to regenerate the injured cells. Both the patients showed remarkable improvement in their functional skills, overall stamina, cognitive abilities, and muscle strength. Furthermore, the improvement in the patients’ conditions were assessed by magnetic resonance tractography and single photon emission computed tomography (SPECT).Conclusions:Therapy with hESCs might emerge as an effective and safe treatment for patients with both MS and LD. Well-designed clinical trials and follow-up studies are needed to prove the long-term efficacy and safety of hESC therapy in the treatment of patients with MS and LD.

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“…1 Se entiende el concepto de PC como un desorden neurológico, con una presentación heterogénea, al igual que sus posibles causas 2 ; en la mayoría de los casos desconocidas pero con un amplio rango de factores asociados, como la asfixia perinatal, bajo APGAR al nacer, bajo peso 3 , género masculino, embarazo múltiple, infecciones intrauterinas, recién nacidos pre-términos. 4,5 (ver tabla 1. Factores asociados, rx).…”

Section: Introductionunclassified