Current profile of cerebral toxoplasmosis in a hospital setting in Dakar

Cissoko, Yacouba; Seydi, Moussa; Déguénonvo, L. Fortes; Attinssounon, A.C.; Nyafouna, S.A. Diop; Manga, N.M.; Badiane, NM Dia; Ndour, Cheikh Tidiane; Soumare, M.; Diop, B; Sow, P S

doi:10.1684/mst.2013.0179

Cited by 2 publications

(7 citation statements)

References 14 publications

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“…The authors of a study conducted in Senegal in 2013 found that anemia (p = 0.003), high CD8 + T cell count (p = 0.009) and coma (p = 0.02) were associated factors at death of PHAs with toxoplasmos [15]. The risk of death was 19 times higher in people with a CD4 count < 200 cells/mm 3 at initiation of ART.…”

Section: Discussionmentioning

confidence: 99%

Pronostic Factors of Cerebral Toxoplasmosis in Department of Infectious and Tropical Diseases at Donka National Hospital

Sow¹,

Sylla²,

Cissé³

et al. 2019

AID

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Objectives: To identify predictive factors for poor prognosis during cerebral toxoplasmosis at Donka Hospital. Methods: It was a retrospective study of descriptive and analytic type lasting one year six months (18 months) from January 1 st , 2016 to June 30 th , 2017 which involved patients admitted and hospitalized for cerebral toxoplasmosis in HIV field. Data enter was performed by Epi data 3.1 software and SPSS 21 software for statistical analysis. The threshold of significance was p < 0.05. Results: We observed 87 cases of cerebral toxoplasmosis (CT). The mean age was 38.53 ± 12.16. The clinical signs were mainly infectious syndrome (100%), headache (69.0%), confusion (46.0%) and meningeal syndrome (41.4%). The lethality was 37.9%. Living with a partner (p = 0.007), CD4 at initiation of antiretroviral therapy < 200 cells/mm 3 (p = 0.009), and coma (p = 0.02) were the factors associated with death. Conclusion: This study showed that cerebral toxoplasmosis is associated with very high morbidity and mortality in the Infectious Diseases Department of Donka National Hospital. Living in a relationship, CD4 counts at baseline < 200 cells/mm 3 and coma were independently associated with death. Special attention to these factors associated with infectious resuscitation and primary prevention in patients with a CD4 T lymphocyte count below 200 cells/mm may improve the prognosis of this pathology.

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Section: Discussionmentioning

confidence: 99%

Pronostic Factors of Cerebral Toxoplasmosis in Department of Infectious and Tropical Diseases at Donka National Hospital

Sow¹,

Sylla²,

Cissé³

et al. 2019

AID

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“…Regarding the frequency of symptoms including fever (100%), headache (100%) and motor deficit (61.9%), we noted a similarity with many studies. 15,17,19 However, the percentage of patients with impaired consciousness (42.9%) was higher than in other series: 30.8% in Togo 15 and 38% in Morocco. 17 The enzyme-linked immunosorbent assay (ELISA) of IgM against the antigen of Toxoplasma gondii is also effective in distinguishing between infection and active toxoplasmosis in the immunocompromised.…”

Section: Discussionmentioning

confidence: 61%

“…It is lower than those noted in other African series ranging from 2.2% to 17.5%. [14][15][16][17][18][19] This low frequency in our study would be explained by a late diagnosis of HIVinfection, a non-respect of primary prophylaxis with cotrimozaxole in some people, the lack of cheap screening and diagnostic tools. To these add the financial difficulties of patients because, since they take care of themselves, some of them die even before the diagnosis is posed.…”

Section: Discussionmentioning

confidence: 96%

“…Cerebral toxoplasmosis was the circumstance in which HIVinfection was found in 47.6% of patients; this rate was 58% in the study of Cissoko et al 19 The delay in diagnosis of HIV infection is a major obstacle to the optimal management of this affection. For this reason, screening policies, as well as clinical management strategies for these patients, need to be revised to reduce HIV-infection related morbidity and mortality.…”

Section: Discussionmentioning

confidence: 98%

“…The mean age of our patients (41.0±18.6 years) is consistent with those found in literature ranging from 38 to 41.5 years. 17,19 This mean age could be explained by the fact that HIV-infection reaches the younger population.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and prognostic features of cerebral toxoplasmosis in HIV-infected patients in Lubumbashi, Democratic Republic of the Congo

Katabwa¹,

Mukuku²,

Kabika³

et al. 2021

JNSK

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Introduction: Cerebral toxoplasmosis is the main opportunistic infection of the central nervous system (CNS) during in human immunodeficiency virus (HIV)-infection. The purpose of this study is to describe current epidemiologic, clinical, diagnostic, and prognostic features of cerebral toxoplasmosis during HIV-infection in hospital setting in Lubumbashi. Methods: This descriptive and analytic study examined the records of 21 HIV-positive patients with cerebral toxoplasmosis. Data were collected over 36 months (from January 2015 to December 2017) at the HIV/AIDS Center of Excellence in Lubumbashi (Democratic Republic of the Congo). Results: Twenty-one patients on 4,283 followed for HIV-infection completed the diagnostic criteria (a prevalence of 0.5%) with a sex ratio (M / F) of 1.3 and a mean age of 41.0±6 years. Major clinical manifestations were fever (100%), headaches (100%), motor deficit (61.9%), intracranial hypertension (47.6%), seizures (47.6%), and disorders of consciousness (42.9%). Cerebral imaging studies (4 Computed tomography scan) were performed and showed hypodensities with peripheral enhancement by cockade in 75% of the cases. The mean CD4 T-cell counts was 180.6±161.9 cells / mm3. Co-trimoxazole was the main anti-toxoplasma drug in all cases. The lethality rate was 42.9%. Conclusion: Early detection and primary prevention in HIV-infected patients remain essential to improve the prognosis and survival of these patients.

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Current profile of cerebral toxoplasmosis in a hospital setting in Dakar

Cited by 2 publications

References 14 publications

Pronostic Factors of Cerebral Toxoplasmosis in Department of Infectious and Tropical Diseases at Donka National Hospital

Pronostic Factors of Cerebral Toxoplasmosis in Department of Infectious and Tropical Diseases at Donka National Hospital

Clinical and prognostic features of cerebral toxoplasmosis in HIV-infected patients in Lubumbashi, Democratic Republic of the Congo

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