2020
DOI: 10.1007/s00262-020-02532-9
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Current progress in NK cell biology and NK cell-based cancer immunotherapy

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Cited by 38 publications
(33 citation statements)
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“…S7e). Recent advances suggested that NK cells could also become exhibited after chronic activation, characterized by the upregulation of KIR, NKG2A, LAG3, and HAVCR2 43,44 , but we did not observe the up-regulation of these exhaustion markers in NK cells. Furthermore, NK cells differentially expressed chemokineencoding genes XCL1 and XCL2, which were previously reported to recruit CCR5 + DCs.…”
Section: Resultscontrasting
confidence: 94%
“…S7e). Recent advances suggested that NK cells could also become exhibited after chronic activation, characterized by the upregulation of KIR, NKG2A, LAG3, and HAVCR2 43,44 , but we did not observe the up-regulation of these exhaustion markers in NK cells. Furthermore, NK cells differentially expressed chemokineencoding genes XCL1 and XCL2, which were previously reported to recruit CCR5 + DCs.…”
Section: Resultscontrasting
confidence: 94%
“…The potential benefits of NK cell-based therapies over T-cell-based therapies include fewer graft-versus-host reactions and the possibility to develop off-the-shelf products [ 86 , 87 ]. A variety of NK cell products (e.g., autologous NK cells, haploidentical NK cells, chimeric antigen receptor NK cells, stem cell-derived NK cells and NK cell lines) have been explored as NK cell-based therapies [ 86 , 87 ]. There is also an increasing number of methods for enhancing NK activity in vivo as reviewed elsewhere [ 86 , 87 ].…”
Section: Strategies That Exploit Nk Cell Response To Improve Ov Efficaciesmentioning
confidence: 99%
“…But these three kinds of cells are considered to be the effector cells of the human body's specific immunity, and are the main functional cells for monitoring malignant diseases in the body. NK cells account for about 10% to 15% of peripheral blood lymphocytes [2]. Circulating NK cells in the blood have a shorter survival time, with a half-life of only 7 -10 days [3].…”
Section: Introductionmentioning
confidence: 99%