Current research trends and challenges in tissue engineering for mending broken hearts

Qasim, Muhammad; Arunkumar, Pala; Powell, Heather M.; Khan, Mahmood

doi:10.1016/j.lfs.2019.05.012

Cited by 36 publications

(19 citation statements)

References 184 publications

(258 reference statements)

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“…HA is a compound already contained and utilized by the body within the connective and epithelial tissues, and drug carriers made from this material can therefore be metabolized. Partly due to this property, it has been used in drug delivery to aid wound repair, cancer treatment, inflammation control, respiratory disease treatment, and regenerative medicine [ 69 , 70 , 71 , 72 ]. It has also found utility in products that aid the regeneration of aged or diseased cells/tissues.…”

Section: Polymeric Materials: Naturally Derived Polymersmentioning

confidence: 99%

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Iovene

Zhao

Wang

et al. 2021

JFB

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Biopolymers are widely accepted natural materials in regenerative medicine, and further development of their bioactivities and discoveries on their composition/function relationships could greatly advance the field. However, a concise insight on commonly investigated biopolymers, their current applications and outlook of their modifications for multibioactivity are scarce. This review bridges this gap for professionals and especially freshmen in the field who are also interested in modification methods not yet in commercial use. A series of polymeric materials in research and development uses are presented as well as challenges that limit their efficacy in tissue regeneration are discussed. Finally, their roles in the regeneration of select tissues including the skin, bone, cartilage, and tendon are highlighted along with modifiable biopolymer moieties for different bioactivities.

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Section: Polymeric Materials: Naturally Derived Polymersmentioning

confidence: 99%

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Iovene

Zhao

Wang

et al. 2021

JFB

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“…In the case of heart transplantation, donor scarcity is one of the major challenges. To overcome these drawbacks, researchers are working towards developing novel bioengineering strategies to repair and regenerate the cardiac tissue after myocardial infarction (MI) [10,11]. One such strategy is to administer growth factors that are vital for the repair and regeneration of cardiac tissue [12].…”

Section: Introductionmentioning

confidence: 99%

Sustained Release of Basic Fibroblast Growth Factor (bFGF) Encapsulated Polycaprolactone (PCL) Microspheres Promote Angiogenesis In Vivo

et al. 2019

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Coronary heart disease (CHD) is the leading cause of death in the Unites States and globally. The administration of growth factors to preserve cardiac function after myocardial infarction (MI) is currently being explored. Basic fibroblast growth factor (bFGF), a potent angiogenic factor has poor clinical efficacy due to its short biological half-life and low plasma stability. The goal of this study was to develop bFGF-loaded polycaprolactone (PCL) microspheres for sustained release of bFGF and to evaluate its angiogenic potential. The bFGF-PCL microspheres (bFGF-PCL-MS) were fabricated using the emulsion solvent-evaporation method and found to have spherical morphology with a mean size of 4.21 ± 1.28 µm. In vitro bFGF release studies showed a controlled release for up to 30 days. Treatment of HUVECs with bFGF-PCL-MS in vitro enhanced their cell proliferation and migration properties when compared to the untreated control group. Treatment of HUVECs with release media from bFGF-PCL-MS also significantly increased expression of angiogenic genes (bFGF and VEGFA) as compared to untreated cells. The in vivo angiogenic potential of these bFGF-PCL-MS was further confirmed in rats using a Matrigel plug assay with subsequent immunohistochemical staining showing increased expression of angiogenic markers. Overall, bFGF-PCL-MS could serve as a potential angiogenic agent to promote cell survival and angiogenesis following an acute myocardial infarction.

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“…Besides fibrin, other biomaterials could be introduced into the current material system in upcoming studies. For example, gelatin has been demonstrated to enhance cell attachment, proliferation, and alignment (Qasim et al, 2019 ). Collagen, as the main component of natural extracellular matrices, has convenient biological properties and is widely used in myocardial tissue engineering (Ashammakhi et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Rapid Fabrication of Cell-Laden Microfibers for Construction of Aligned Biomimetic Tissue

Fang

et al. 2021

Front. Bioeng. Biotechnol.

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Bottom-up engineering of tissue constructs is being rapidly developed and broadly applied in biomanufacturing. As one type of building block, cell-laden microfibers are promising for reconstruction of oriented structures and functions of linear tissues, such as skeletal muscles, myocardia, and spinal cord tissues. Herein, we propose wet-spinning method with agitating collection, wherein alginate-based material is extruded into an agitated CaCl2 bath with a magnetic rotor acting as the microfiber collector. By applying this method, we achieve rapid fabrication and oriented collection of hydrogel microfibers with diameters ranging from 100 to 400 μm. In addition, we encapsulate myoblasts in the hydrogel to form cell-laden microfibers, which show a high viability (more than 94%) during in vitro culture. Moreover, the method allows to fabricate of cell-laden core–sheath microfibers and hollow microfibers. We also fabricate 3D constructs using various methods of microfiber assembly like weaving and braiding. The assembling results suggest that the proposed method is a promising technology for bottom-up engineering of aligned biomimetic tissue constructs.

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Current research trends and challenges in tissue engineering for mending broken hearts

Cited by 36 publications

References 184 publications

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Bioactive Polymeric Materials for the Advancement of Regenerative Medicine

Sustained Release of Basic Fibroblast Growth Factor (bFGF) Encapsulated Polycaprolactone (PCL) Microspheres Promote Angiogenesis In Vivo

Rapid Fabrication of Cell-Laden Microfibers for Construction of Aligned Biomimetic Tissue

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