BACKGROUNDLeprosy is a chronic infectious disease caused by Mycobacterium leprae mainly affecting the skin, peripheral nerves. Leprosy has been officially eliminated from India since December 2005, still wide variations in prevalence rates continue to exist across the states and regions in the country. Aims and Objectives-The Purpose of the study is to determine the prevalence of smear-positive leprosy cases in post-elimination era in a rural tertiary care hospital in Nandyal, Andhra Pradesh.