Grade 2 Deformity and New Leprosy Cases, an Issue of Concern- A Retrospective, Descriptive Study in a Tertiary Care Hospital

Rajaram, Muthukumaran; Pandiyan, Subhashini Sundarara; Alagarsamy, Sudha

doi:10.14260/jemds/2017/1001

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…This discordance in our study could be explained by the patient profile disparity at the starting of the treatment and the onset of follow-up as patients may not develop multiple nerve trunk enlargement at the beginning and this nerve thickening might be more in patients with complex progression of the disease. Even if in this study the sex and first lesion body part were not found to be statistically significant, the higher rate of disability associated with the male sex in our study was noted by others as well [ 35 ]. It can be explained by the fact that males are more prone to trauma to hands and feet as part of their occupation.…”

Section: Resultscontrasting

confidence: 68%

Determinant factors of leprosy-related disability; comparison of acceleration failure time and parametric shared frailty models

et al. 2023

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Background Leprosy is an illness persisting for a long time or constantly recurring brought about by Mycobacterium leprae. The collusion of the causing agent with Schwann cells leads to incapable of being changed loss of fringe nerve tissue; followed by incapacity and that is not restricted to actual powerlessness yet additionally makes a negative picture, prompting segregation and social disgrace against the altered people also, their families. Methods The analysis of this study comprises 205 samples of patients at All African TB and Leprosy Rehabilitation and Training Centre from January 2015 up to December 2019 G.C who were taking medication for leprosy and who possess all necessary data. Territorial conditions in the region of the patients were utilized as a clustering impact in all frailty models. Acceleration failure time models and parametric shared frailty models with Weibull and log-strategic patterns were utilized to dissect hazard factors related to disability ensued by leprosy. All fitted models were looked at by utilizing AIC. Results From that of 205, 69(33.7%) experienced at least one kind of disability grade during treatment taking. In light of AIC, log-logistic-gamma shared frailty model was the final best fitting model and also there was considerable variation among patients. The final model showed the age of patients, symptom duration, treatment category of patients, and sensory loss were found to be the most significant determinants of leprosy disability. Conclusion In this investigation, there is proof of heterogeneity at the group level and disability was related to the age of patients, symptom duration, treatment category of patient, what’s more, sensory loss subsequently, uncommon consideration ought to be given to these huge indicators, which eventually diminish the event of disability. To lessen the patient-related postponement, the program should lay more noteworthy accentuation on bringing issues to light in the local area by zeroing in on key messages like indications, inability result of the late discovery, accessibility of free treatment what’s more, accessibility of disease care in general wellbeing office.

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Section: Resultscontrasting

confidence: 68%

Determinant factors of leprosy-related disability; comparison of acceleration failure time and parametric shared frailty models

et al. 2023

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“…The higher rate of disability associated with male sex in our study was noted by others as well. [6789] It can be explained by the fact that males are more prone to trauma to hands and feet as part of their occupation. A statistically significant association noted for disability and age above 45 years is in accordance with several other studies.…”

Section: Discussionmentioning

confidence: 99%

Clinico-epidemiological study of disability due to leprosy at the time of diagnosis among patients attending a tertiary care institution

et al. 2019

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Background: With the declared elimination of leprosy as a public health problem, the World Health Organization has shifted the focus on the disabilities and deformities associated with leprosy. Aims: The aim was to study the Grade 1 and Grade 2 disability among newly diagnosed leprosy patients. Materials and Methods: All newly diagnosed leprosy patients attending the Outpatient Department of Government Medical College, Kozhikode, from January 1, 2013 to December 31, 2013 were included in the study and the Grade 1 and Grade 2 disabilities observed were analyzed. Results: During the 1-year period, 76 patients were diagnosed to have leprosy. Grade 1 and Grade 2 disabilities were noted in 31.6% and 17.1%, respectively. Major factors identified as risk for leprosy disability at the time of diagnosis were age >45 years, >5 skin lesions, ≥2 thickened peripheral nerve trunks, pure neuritic and borderline tuberculoid spectra of leprosy. Limitation: As the study was conducted in a tertiary care center, it does not perfectly indicate the status in the community. Conclusion: Disability noted in nearly 50% of leprosy cases at the time of diagnosis highlights the need to improve the effectivity of existing health-care system in early case detection and timely referral. In addition, it underscores the need to educate the affected regarding protective eye, foot, and hand care, so that progression to Grade 2 disability can be prevented.

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“… 10 Even if in this study sex and first lesion body part were not found to be statistically significant, others have noticed the greater rate of impairment connected with male sex and it was in our study as well. 14 It can be explained by the fact that males are more prone to hand and foot damage as a result of their work. 15 Described the most common location of disability as the feet, whereas others, like ourselves, identified the hands as the most commonly involved region in terms of disability.…”

Section: Discussionmentioning

confidence: 99%

Time-to-Disability Determinants Among Leprosy Patients Enrolled for Treatment at ALERT Center, Addis Ababa, Ethiopia: A Survival Analysis

Masresha¹,

Biresaw²,

Moyehodie³

et al. 2022

IDR

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Background Mycobacterium leprae causes leprosy, which is a long-term or recurrent infection. The causative agent’s collusion with Schwann cells results in the irreversible loss of fringe nerve tissue; followed by incapacity, which includes not just actual impotence but also mental incapacity, creates a bad image of the transformed, resulting in segregation and societal humiliation of leprosy patients, as well as their families. Methods This study’s survival analysis includes a sample of 205 patients who were taking leprosy medication and had all essential data from January 2015 to December 2019 G.C. at the All African TB and Leprosy Rehabilitation and Training Centre. The Cox proportional hazard model was used to figure out what factors influence leprosy patients’ survival status during treatment. Results Among the 205 leprosy patients, 71 (34.63%) had at least one type of impairment grade during treatment. The Cox proportional model revealed that the most significant variables of impairment among leprosy patients were age, symptom duration, treatment category, living place, and sensory loss. Conclusion The study investigated and revealed characteristics associated with the survival status of leprosy patients in ALRT centers using survival analysis. Patients’ risk of worsening disability grade increased with age, was greater for patients with a long duration of symptom, was higher for defaulter patients, and was lower for patients who did not lose their sensibility throughout therapy. The existence of a difference in the survival curves between two or more groups of factors for the patient’s survival function was also discovered in this inquiry. Female patients, particularly those who were new to the medication, were shown to be more in their survival.

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Grade 2 Deformity and New Leprosy Cases, an Issue of Concern- A Retrospective, Descriptive Study in a Tertiary Care Hospital

Cited by 3 publications

References 25 publications

Determinant factors of leprosy-related disability; comparison of acceleration failure time and parametric shared frailty models

Determinant factors of leprosy-related disability; comparison of acceleration failure time and parametric shared frailty models

Clinico-epidemiological study of disability due to leprosy at the time of diagnosis among patients attending a tertiary care institution

Time-to-Disability Determinants Among Leprosy Patients Enrolled for Treatment at ALERT Center, Addis Ababa, Ethiopia: A Survival Analysis

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