Current state of IR spectroscopy applied to pharmaceutical analysis

Abstract

Various techniques of IR spectroscopy are considered from the standpoint of their application in pharmaceutical analysis. It is demonstrated that attenuated total reflectance in the mid-IR range and near-IR spectroscopy are promising techniques for pharmaceutical analysis. 466 0091-150X/08/4208-0466

Analysis of rimantadine hydrochloride by near-ir spectroscopy

“…Identification of a substance or drug manufacturer is one of the problems that can currently be solved using near-IR spectroscopy [1]. This is due to the emergence on the pharmaceutical market of many counterfeit drugs.…”

“…Near-IR (NIR) spectroscopy has a long history but has been widely used to analyze drugs only in the last decade [1]. The stimulus for this has been mainly the invention of appropriate instruments and their combination with quantitative methods for processing spectra of compounds.…”

Analysis of ranitidine hydrochloride by near IR spectroscopy

“…Studies were performed using an Antaris II IR Fourier spectrometer from Thermo Electron Corporation (Intertek, USA) with an integrating sphere; resolution was 8 cm -1 , the 1 number of scans was 16, the measurement range from was 4000 to 10,000 cm -1 . The standard for constructing baseline plots was Teflon, using 32 scans.…”