Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and Its Bioactive Components

Poulios, Efthymios; Giaginis, Constantinos; Vasios, Georgios K.

doi:10.1055/a-1087-8276

Cited by 40 publications

(35 citation statements)

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“…Poulios et al [34] well summarized the current advances on the extraction and identification of bioactive components of sage; further, the same authors gave a current state-of-the-art on the antioxidant activity of sage (Salvia spp.) and its bioactive components [35].…”

Section: Introductionmentioning

confidence: 99%

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

Zaccardelli

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Caputo

et al. 2020

Forests

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Sage species belong to the family of Labiatae/Lamiaceae and are diffused worldwide. More than 900 species of sage have been identified, and many of them are used for different purposes, i.e., culinary uses, traditional medicines and natural remedies and cosmetic applications. Another use of sage is the application of non-distilled sage extracts and essential oils to control phytopathogenic bacteria and fungi, for a sustainable, environmentally friendly agriculture. Biocidal propriety of non-distilled extracts and essential oils of sage are w documented. Antimicrobial effects of these sage extracts/essential oils depend on both sage species and bacteria and fungi species to control. In general, it is possible to choose some specific extracts/essential oils to control specific phytopathogenic bacteria or fungi. In this context, the use of nanotechnology techniques applied to essential oil from salvia could represent a future direction for improving the performance of eco-compatible and sustainable plant defence and represents a great challenge for the future.

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Section: Introductionmentioning

confidence: 99%

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

Zaccardelli

Pane

Caputo

et al. 2020

Forests

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“…To counteract this shortcoming, plant-based products have been increasingly tested for their antihypertensive effects. For example, plants belonging to the genus Salvia have been reported to inhibit ACE activity owing to the presence of a high content of aromatic compounds in it with antioxidant functions [ 22 ], such as caffeic acid, rosmarinic acid and lithospermic acid [ 23 , 24 , 25 , 26 ]. S. hispanica is a plant with interesting properties that can mimic synthetic ACEIs and provide potential health benefits, without side-effects.…”

Section: Discussionmentioning

confidence: 99%

“…The in vivo assays revealed that administration of EESH inhibited the increase in BP in the hypertensive rats, an effect similar to that observed with the administration of captopril. Hypotensive effects have been observed upon treatment with isolated fractions of plant extracts, mainly associated with the presence of compound antioxidants, saponins and peptides [ 17 , 24 , 30 ]. The mode of action of the inhibitory effect is proposed to be the interaction of antioxidant molecules with different motifs on the ACE catalytic site [ 28 ], specifically, the union of these compounds with the zinc atom present in the catalytic site of ACE, as described by Reeves and Rossow [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, Steinkamp-Fenske et al [ 21 ] and Zhou et al [ 32 ] analyzed the effect of administration of S. milthiorriza extracts on the regulation and production of NO in a human umbilical endothelium-derived cell line. The authors found a concentration-dependent response besides an over-regulation of eNOS in the treated cells, as compared to control cells [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. We analyzed genes coding for proteins that participate in three different pathways involved in regulation of HT, namely renin–angiotensin system ( Ace and Agtr1a genes), the kallikrein–kinin system ( Bdkrb2 gene) and the nitric oxide ( Nos3 gene) synthesis pathway.…”

Section: Discussionmentioning

confidence: 99%

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Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

et al. 2020

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Hypertension (HT) is considered to be a potential risk factor for cardiovascular diseases and has been directly related to pathologies such as obesity and dyslipidemias. Angiotensin-converting enzyme inhibitors (ACEIs) blocked the renin-angiotensin-aldosterone cascade diminishing the production of angiotensin II and the level of bradykinin, produced by the kallikrein-kinin system. Although ACEIs are effective therapeutics in regulating HT, they present several side-effects that can be due to their mechanism of action (as hypotension, cough, dizziness, light-headedness or hyperkalemia) to specific drug molecular structure (skin rash, neutropenia and tasting disorders) or due to associated pathologies in the patients (it has been considered a possible nephrotoxic effect when ACEIs are administered in combination with angiotensin receptor blockers, in patients that present comorbidities as diabetes, acute kidney injury or chronic kidney disease). Therefore, it is necessary the searching for new products with ACEI activity that do not produce side effects. Interestingly, species of the plant genus Salvia have been found to possess hypotensive effects. In the present study, we analyzed the effects of the ethanolic extract of Salvia hispanica L. seeds (EESH) on the expression of genes involved in pathways regulating HT. Administration of EESH to hypertensive rats inhibited the angiotensin-converting enzyme (ACE) activity along with a decrease in Ace and elevation of Agtr1a and Nos3 gene expression, as compared to that in healthy rats. Moreover, these results were similar to those observed with captopril, an antihypertensive drug used as a control. No significant change in the expression of Bdkrb2 gene was observed in the different groups of rats. To conclude, our results demonstrate that EESH regulates blood pressure (BP) in hypertensive rats through transcriptionally regulating the expression of genes that participate in different pathways involving ACE.

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“…Common and highly valued herbs include lemon balm, sage and nettle, which show various health-promoting benefits, and thanks to the presence of essential oils they have sedative and anti-stress effects. Furthermore, these plants show strong antioxidant properties (Poulios et al, 2020;Bonetti et al, 2016;Kasapidou et al, 2014), which makes them useful for reducing stress induced by high air temperature. However, the literature reports no information concerning the use of these herbs to alleviate the effects of heat stress on the avian body.…”

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confidence: 99%

The Effect of Adding Herbal Extracts to Drinking Water on Body Temperature, Level of Thyroid Hormones and H:L Ratio in the Blood of Broiler Chickens Exposed to Elevated Ambient Temperature

Skomorucha

Sosnówka-Czajka

2021

Annals of Animal Science

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The aim of the study was to determine the effect of supplementing drinking water with extracts from lemon balm, sage and nettle on body temperature, level of thyroid hormones and the heterophil to lymphocyte (H:L) ratio in the blood of broiler chickens exposed to elevated rearing temperature. One-day-old Ross 308 chicks were divided into four groups: group I (CON) and experimental groups II (LB), III (S) and IV (N), in which, from 22 to 42 days of rearing, drinkers were supplemented with lemon balm extract, sage extract or nettle extract (2 ml/l water), respectively. In addition, at 5 weeks of growth, all the groups were exposed to elevated ambient temperature (up to 30°C) for 5 days, after which the recommended thermal conditions were reinstated. During the study, mortality, rectal temperature and radiated temperature of the broilers were monitored. Blood was collected from 10 birds per group to determine the concentration of thyroid hormones (T3 and T4) and to make blood smears. The H:L ratio was determined based on the percentage of heterophils (H) and lymphocytes (L). The herbal extracts from lemon balm, sage and nettle, added to drinking water at 2 ml/l, reduced the blood level of the thyroid hormone (triiodothyronine) and rectal temperature in the experimental broilers during the initial period of thermal stress. Chickens receiving the nettle extract were also characterised by lower radiated temperature of the unfeathered body, a lower H:L ratio in the blood during the increase in ambient temperature, and the lowest mortality percentage. It can therefore be considered that the dietary supplementation of nettle, in the form and concentration used in this study, had the most favourable effect on the physiological status of the birds (body temperature, level of thyroid hormones and H:L ratio) ratio exposed to elevated ambient temperatures (30oC), and thus on their welfare.

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Current State of the Art on the Antioxidant Activity of Sage (Salvia spp.) and Its Bioactive Components

Cited by 40 publications

References 82 publications

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

Sage Species Case Study on a Spontaneous Mediterranean Plant to Control Phytopathogenic Fungi and Bacteria

Ethanolic Extract of Salvia hispanica L. Regulates Blood Pressure by Modulating the Expression of Genes Involved in BP-Regulatory Pathways

The Effect of Adding Herbal Extracts to Drinking Water on Body Temperature, Level of Thyroid Hormones and H:L Ratio in the Blood of Broiler Chickens Exposed to Elevated Ambient Temperature

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