Current Status and Future Directions of Chronic Cough in China

Lai, Kefang; Li, Long

doi:10.1007/s00408-019-00319-z

Cited by 16 publications

(12 citation statements)

References 70 publications

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“…Studies in Shanghai (Ma et al, 2009;Yu et al, 2009;Ding et al, 2019) and Chongqing (Cao et al, 2009) showed that the proportion of females can reach 60% or more in chronic cough patients, which is consistent with the data of Europe and America, while patients with chronic cough have a roughly equal sex distribution in Guangzhou (Deng et al, 2016;Lai et al, 2019), Lanzhou (Liu et al, 2016), and Beijing (Liu and Lin, 2009). In a national-wide multi-center study, except for a eastern region (Shanghai), chronic cough patients presented an approximately equal gender distribution in western, southern, northern, and northeastern regions of China (Lai et al, 2013;Lai and Long, 2020). What's more, a female predominance among patients with refractory or unexplained chronic cough has been reported (Ryan et al, 2012;Muccino et al, 2020;Smith et al, 2020) (more specific details about sex distribution are shown in Table 1).…”

Section: Introductionmentioning

confidence: 98%

Gender Difference in Chronic Cough: Are Women More Likely to Cough?

Bai

Sha

et al. 2021

Front. Physiol.

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Chronic cough is a common complaint for patients to seek medical cares all over the world. Worldwide, about two thirds of chronic cough patients are females. However, in some regions of China the prevalence of chronic cough between sexes is roughly the same. Estrogen and progesterone can not only have an effect on transient receptor potential vanilloid 1 channel, eosinophils and mast cells, but also influence laryngeal dysfunction, gastroesophageal reflux disease and obstructive sleep apnea hypopnea syndrome, which may lead to increased cough sensitivity in women. On the other hand, the quality of life was adversely affected more in female patients with chronic cough. Both hormones possibly cause gender difference in chronic cough.

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Section: Introductionmentioning

confidence: 98%

Gender Difference in Chronic Cough: Are Women More Likely to Cough?

Bai

Sha

et al. 2021

Front. Physiol.

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“…It has been reported that the concentration of air pollutants was higher in northern China than in southern China [ 76 , 77 ]. Number of research reported that the air pollution is an important risk factor for chronic cough [ 19 , 21 , 32 , 40 , 49 , 50 ]. The evidence mentioned above imply that environmental factors may account for the regional variation in the prevalence of chronic cough.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of chronic cough in China: a systematic review and meta-analysis

Liang

Wang

et al. 2022

BMC Pulm Med

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Background Individual studies have indicated variable prevalence for chronic cough, but thus far, there has been no systematic report on the prevalence of this condition. Methods In this study, we performed a systematic review and meta-analysis by searching databases including PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Chinese biomedical literature service system, Wanfang Database, and VIP database, for studies on chronic cough in China published before December 28, 2020. A random effects model was used to calculate pooled prevalence estimates with 95% confidence interval [95%CI], weighted by study size. Results Fifteen studies with 141,114 community-based adults were included in the study, showing a prevalence of 6.22% (95% CI 5.03–7.41%). And 21 studies with 164,280 community-based children were included, presenting a prevalence of 7.67% (95% CI 6.24–9.11%). In subgroup meta-analyses, the prevalence in adults was 4.38% (95% CI 2.74–6.02%) in southern China and 8.70% (95% CI 6.52–10.88%) in northern China. In the children population, the prevalence in northern China was also higher than in southern China (northern vs. southern: 7.45% with a 95% CI of 5.50–9.41%, vs. 7.86% with a 95% CI of 5.56–10.16%). Conclusions Our population-based study provides relatively reliable data on the prevalence of chronic cough in China and may help the development of global strategies for chronic cough management.

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“…Chronic cough is often the only symptom of CVA [ 2 ]. CVA is the most common cause of chronic cough in China [ 3 ] and the second most common cause of chronic cough in Korea [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence‐Based Medicine Approach Validation

Xia

Liu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the pharmacological mechanism of HuangQiXiXin decoction (HQXXD) on cough variant asthma (CVA) and validate the clinical curative effect. Methods. The active compounds and target genes of HQXXD were searched using TCMSP. CVA-related target genes were obtained using the GeneCards database. The active target genes of HQXXD were compared with the CVA-related target genes to identify candidate target genes of HQXXD acting on CVA. A medicine-compound-target network was constructed using Cytoscape 3.6.0 software, and a protein-protein interaction (PPI) network was constructed using the STRING database. Gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using RGUI3.6.1 and Cytoscape 3.6.0. We searched the main database for randomized controlled trials of HQXXD for CVA. We assessed the quality of the included studies using the Cochrane Reviewers’ Handbook. A meta-analysis of the clinical curative effect of HQXXD for CVA was conducted using the Cochrane Collaboration’s RevMan 5.3 software. Results. We screened out 48 active compounds and 217 active target genes of HQXXD from TCMSP. The 217 active target genes of HQXXD were compared with the 1481 CVA-related target genes, and 132 candidate target genes for HQXXD acting on CVA were identified. The medicine-compound-target network and PPI network were constructed, and the key compounds and key targets were selected. GO function enrichment and KEGG pathway enrichment analysis were performed. Meta-analysis showed that the total effective rate of the clinical curative effect was significantly higher in the experimental group than the control group. Conclusion. The pharmacological mechanism of HQXXD acting on CVA has been further determined, and the clinical curative effect of HQXXD on CVA is remarkable.

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Current Status and Future Directions of Chronic Cough in China

Cited by 16 publications

References 70 publications

Gender Difference in Chronic Cough: Are Women More Likely to Cough?

Gender Difference in Chronic Cough: Are Women More Likely to Cough?

Prevalence of chronic cough in China: a systematic review and meta-analysis

Network Pharmacology Strategy to Investigate the Pharmacological Mechanism of HuangQiXiXin Decoction on Cough Variant Asthma and Evidence‐Based Medicine Approach Validation

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